Clinical trials: Ivf
Fertility Preservation
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or…
- Trial name
- HOLIDAY (NCT07225660)
- Testing
- OCP pause
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility
Comparison of 2 Ovarian Stimulation Protocols for Women With Low Ovarian Reserve
The purpose of this study is to determine whether minimal ovarian stimulation for in vitro fertilization is superior to high dose stimulation. Number of mature eggs, number of embryos as well as pregnancy rates will be compared.
- Trial name
- NCT02128360
- Testing
- Letrozole, Gonadotropins, Gonadotropins
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist
The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting.
- Trial name
- NCT00835523
- Where
- 10 sites in Germany
- Volunteers
- 51 people
- Sponsor
- University Hospital Schleswig-Holstein
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility
Efficacy of Hypnosis During Embryo Transfer Procedure on Clinical Pregnancy Rate for Patients Undergoing Assisted Reproductive Technology IVF or ICSI
The purpose of this study is to compare the clinical benefits that can be expected by the Embryo transfert procedure with hypnosis to the usual embryo transfer procedure
- Trial name
- HYPNOART (NCT02003157)
- Testing
- hypnosis during embryo transfer or usual transfer procedure
- Where
- France
- Volunteers
- 460 people
- Sponsor
- University Hospital, Angers
Effectiveness of Isoamyl-2-cyanoacrylate With and Without Ethiodized Oil in Occluding Hydrosalpinx Prior to IVF
Hysteroscopic Tubal Occlusion Using Amacrylate With or Without Lipidol in Patients With Hydrosalpinx Prior to IVF
Hysteroscopic tubal occlusion using iso-amyl- 2-cyanoacrylate with or without Ethiodized oil (Lipidol) in patients with hydrosalpinx prior to IVF
- Trial name
- NCT06130072
- Testing
- iso-amyl- 2-cyanoacrylate., iso-amyl- 2-cyanoacrylate mixed with Ethiodized oil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility, Female, Ovarian Insufficiency
Benefit of Follicular Flushing During Oocyte Retrieval for Poor Responder Patient in an Assisted Reproductive Technology Program
The object of this study is to determine the benefit of follicular flushing with a double channel needle in a poor responder population for a maximum number of oocytes to be retrieved.
- Trial name
- NCT01329302
- Testing
- Direct aspiration needle Echo tip® Cook® single Lumen and Follicular flushing with double lumen needle Echo tip® Cook® Double Lumen Aspiration
- Where
- France
- Volunteers
- 257 people
- Sponsor
- University Hospital, Strasbourg, France
Polycystic Ovarian Syndrome, Infertility
Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)
This multicenter, randomized, open-label exploratory study will be performed in approximately 200 polycystic ovary syndrome (PCOS) but otherwise healthy females undergoing in vitro fertilization (IVF).
- Trial name
- NCT00805935
- Testing
- Menotropin, Progesterone vaginal insert, Follitropin beta
- Where
- 6 sites in United States
- Volunteers
- 110 people
- Sponsor
- Ferring Pharmaceuticals
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
Focus of Study Instead
Endometrial Injury Increases Implantation and Pregnancy Rates
Objective To evaluate the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI -ET cycles with recurrent implantation failure. Design Randomized controlled clinical study.
- Trial name
- NCT01340560
- Testing
- Endometrial biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Luteal Phase, in Vitro Fertilisation
Early Luteal Hormones and IVF Outcomes After hCG Triggering
It has recently been demonstrated that a bolus trigger of hCG induces various unphysiological conditions in the early luteal phase that may negatively affect an IVF treatment cycle's reproductive outcome.
- Trial name
- NCT04693624
- Testing
- Hormonal levels
- Where
- Vietnam
- Volunteers
- 95 people
- Sponsor
- Mỹ Đức Hospital
Infertility (IVF Patients), Infertility Female
Norethindrone Impact on Receptiva Outcomes
This retrospective study aims to evaluate pregnancy outcomes in patients with a positive BCL6 test (ReceptivaDx, who were treated with either norethindrone acetate or Depo Lupron prior to embryo transfer.
- Trial name
- NIRO (NCT07134920)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Inception Fertility Research Institute, LLC
No Condition
Comparison of Clinical Outcomes Between IVM and Minimal Stimulation IVF in Patients With PCOS
Polycystic ovarian syndrome (PCOS) is most common endocrinologic disease in women of reproductive age with incidence of 6.6 ~ 8%.
- Trial name
- NCT03134482
- Testing
- IVM, Minimal stimulation IVF
- Where
- 2 sites in South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHA University
Sperm Capacitation
Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment
Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments
- Trial name
- NCT00731159
- Testing
- sperm capacitation, biologic
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Metabolic Syndrome
In Vitro Fertilization Outcomes in Metabolic Syndrome
The purpose of this study is to examine the effect of metabolic syndrome in over-weight women on IVF treatment outcomes.
- Trial name
- NCT01958424
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Infertility
GnRH Agonist Trigger and Modified Luteal Phase Support, Adding a Bolus of GnRHa at the Time of Implantation - a RCT
Purpose:The aim of this project is to prospectively determine whether a single dose of GnRH-agonist administered at the time of implantation increases or not the reproductive outcome in patients undergoing in vitro fertilization…
- Trial name
- GTMLPSGI (NCT02053779)
- Testing
- Triptorelin 0.1mg
- Where
- Algeria
- Volunteers
- 328 people
- Sponsor
- Centre Hospitalier Universitaire Ibn Rochd
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility
Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions
This trial investigates the effects of FE 200440 compared to placebo on implantation rate in women undergoing IVF/ICSI treatment
- Trial name
- BASIC (NCT01723982)
- Testing
- Barusiban (FE 200440)
- Where
- 14 sites in Australia, Belgium and 4 more
- Volunteers
- 256 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Rekovelle PK Trial in Chinese Women
FE 999049 is a gonadotropin preparation containing recombinant human follicle stimulating hormone (rhFSH) under development by Ferring Pharmaceuticals.
- Trial name
- NCT04150861
- Testing
- Follitropin Delta
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility, IVF
PICSI RCT in Couples With a Previous Poor Fertilisation Cycle in IVF
Poor fertilisation plays a significant role in poor artificial reproductive technique outcomes. Male factor infertility accounts for a large portion of such cases.
- Trial name
- NCT05017740
- Testing
- ICSI, PICSI
- Where
- Singapore
- Volunteers
- 47 people
- Sponsor
- KK Women's and Children's Hospital
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