Clinical trials: Joint
Rheumatoid Arthritis
Job Adaptation in Patients With Rheumatoid Arthritis
The specific aim of this study is to compare the rate of negative work role events in individuals with rheumatoid arthritis compared to healthy controls.
- Trial name
- NCT00412399
- Where
- 2 sites in United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Bone Cancer, Articular Disease
18F-sodium Fluoride (NaF) PET to Replace Bone Scintigraphy: Safety and Efficacy Assessment
18F-sodium fluoride (18F-NaF) was already investigated numerous times in the last 40 years as a PET alternative to standard 99m-technetium-derived bone scintigraphy.
- Conditions
- Bone Cancer, Articular Disease, Infectious Disease
- Trial name
- NCT04842071
- Testing
- 18F-sodium fluoride
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Osteoarthritis
A First-in-human Study to Investigate Safety and Tolerability of SAR446959 in Participants With Osteoarthritis of the Knee
This is a randomized, placebo-controlled, participant- and Investigator-blinded Phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of ascending single intra-articular doses of SAR446959 in…
- Trial name
- NCT06704932
- Testing
- SAR446959
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Sanofi
Juvenile Idiopathic Arthritis
Methotrexate Alone vs Methotrexate + Etanercept for Minimal/Low Disease Activity in Juvenile Idiopathic Arthritis
This open labelled randomized controlled trial will be carried out at the University of Child Health and the Children's Hospital, Lahore consisting of 6 months .
- Trial name
- NCT07386587
- Testing
- Injection, Etanercept, 25 Mg (Code May Be Used for Medicare When Drug Administered Under the Direct Supervision of A Physician, Not for Use When Drug is Self Administered)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Shoulder Pain, Shoulder Impingement Syndrome
Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury
Rotator cuff disease (i.e., rotator cuff tendinopathy or tear) is a common cause of shoulder pain in persons with chronic spinal cord injury (SCI).
- Conditions
- Shoulder Pain, Shoulder Impingement Syndrome, Rotator Cuff Impingement Syndrome, Rotator Cuff Tendinitis
- Trial name
- NCT03167138
- Testing
- Autologous micro-fragmented adipose tissue, Lipogems system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Arthritis, Psoriatic
Study Evaluating the Safety of Enbrel (Etanercept)
The purpose of this study is to collect post-marketing information on the safety of Enbrel in Filipino patients.
- Trial name
- NCT00683384
- Testing
- Etanercept (Enbrel)
- Where
- Philippines
- Volunteers
- 93 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of ABT-122 in subjects with Rheumatoid Arthritis.
- Trial name
- NCT01853033
- Testing
- ABT-122
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
Main Study: Primary Objective: Assess the long term safety of sarilumab in participants with rheumatoid arthritis (RA). Secondary Objective: Assess the long term efficacy of sarilumab in participants with RA.
- Trial name
- NCT01146652
- Testing
- SAR153191 (REGN88)
- Where
- 335 sites in United States, Argentina and 38 more
- Volunteers
- 2,023 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
More Added Value of Therapeutic Education in the Management of Patients With Rheumatoid Arthritis (ETP-PR)
Taking into account the recommendations of the Health Authority [1] and the application of patients' associations, we have structured a course of therapeutic education includes three stages for patients with rheumatoid arthritis…
- Trial name
- ETP-PR (NCT01564147)
- Testing
- immediate therapeutic education, therapeutic education delayed
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Nantes University Hospital
Avascular Necrosis, Acute Lymphoblastic Leukemia
AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or Prednisone
The primary purpose of this study is to compare the incidence of AVN in children with hematologic malignancies treated with prednisone versus dexamethasone during continuation.
- Trial name
- NCT00719147
- Testing
- MRI, Functional Status and Symptom Questionnaire
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- St. Jude Children's Research Hospital
Rheumatoid Arthritis
Bucillamine Study of Holding Remission After Infliximab Dose-off
Patients with rheumatoid arthritis who have been well controlled with methotrexate plus infliximab may remain in remission or low disease activity without infliximab.
- Trial name
- NCT00716248
- Testing
- bucillamine, methotrexate
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Saitama Medical University
Osteoarthritis of the Knee
A Comparative Study of Knee Systems
The custom cutting guides personalized for each patient via pre-operative MRI will result in significantly faster intraoperative time with comparable knee alignment accuracy, cost, knee function, and patient satisfaction.
- Trial name
- Bake-Off (NCT01331278)
- Testing
- Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Foundation for Southwest Orthopedic Research
Osteoarthritis, Rheumatoid Arthritis
Reciprocating Medical Devices - a Study of a New Safety Device
The study design is a randomized study to directly compare the performance and the outcome of syringe and needle procedures with a standard syringe or the new reciprocating procedure device (RDP), which is a type of safety…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Trauma, Thyroid Nodule
- Trial name
- RPD (NCT00651625)
- Testing
- Reciprocating Procedure Device (RPD) - AVANCA Re No. 1091001, conventional syringe - BD Ref 309604
- Where
- United States
- Volunteers
- 437 people
- Sponsor
- University of New Mexico
Osteoarthritis, Knee
Effects of Digital-based Physical Activity Intervention in Individuals With Knee Osteoarthritis
Physical activity is recommended in the guidelines to improve pain and function in the treatment of knee OA, regardless of the severity of the disease, but still, patients rarely do enough physical activity.
- Trial name
- NCT05810376
- Testing
- Digital-based physical activity intervention, Patient education and exercise
- Volunteers
- 70 people
- Sponsor
- Trakya University
Osteoarthritis, Knee
STepped Exercise Program for Knee OsteoArthritis
Knee osteoarthritis (OA) is one of the most common chronic conditions and a leading cause of disability among Veterans. Although exercise is known to improve pain, physical abilities, and other outcomes for patients who have knee…
- Trial name
- STEP-KOA (NCT02653768)
- Testing
- Stepped Exercise Program, Arthritis Education
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- VA Office of Research and Development
Pain, Postoperative
Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery
Surgical trauma causes nerve sensitization leading to amplification and prolongation of postoperative pain. In experimental studies, pre-injury neural blockade using local anesthetics has been shown to reduce post-injury…
- Trial name
- NCT01693900
- Testing
- Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Randy Fayne, DO
Ankylosing Spondylitis
Efficacy and Safety of Risedronate (Actonel), a Third Generation Bisphosphonate in Patients With Ankylosing Spondylitis: a Phase 2 Pilot Study
Randomized, controlled, double-blind, multicenter phase II study comparing risedronate 35mg (ActonelR 35mg weekly tablet) versus placebo in patients with active ankylosing spondylitis (AS) treated with standard first and…
- Trial name
- NCT01038011
- Testing
- drug treatment
- Where
- Switzerland
- Sponsor
- University of Zurich
Rheumatoid Arthritis, Axial Spondyloarthritis
Observational Study to Evaluate the Real-Life Effectiveness of Benepali Following Transition From Enbrel
The primary objective is to evaluate the effectiveness of Benepali in participants with Rheumatoid Arthritis (RA) and axial spondyloarthritis (axSpA), including participants with Ankylosing Spondylitis (AS) and non-radiographic…
- Trial name
- BENEFIT (NCT03100734)
- Testing
- Benepali, Enbrel
- Where
- Germany
- Volunteers
- 585 people
- Sponsor
- Biogen
Spondyloarthropathy
Rehabilitative Therapy and Pridinol in Patients With Lumbar Spondylarthrosis and Chronic Low Back Pain
Spondyloarthrosis is a degenerative disease involving the intervertebral disc, vertebral bodies, and adjacent soft tissues. Treatment aims to slow disease progression and manage symptoms through an interdisciplinary approach.It…
- Trial name
- NCT06252064
- Testing
- Rehabilitation + Drug therapy, Rehabilitation, Drug therapy
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of Palermo