Clinical trials: Joint Hypermobility Syndrome
Hip Dysplasia, Hypermobility Syndrome
Dynamic Lycra Garments for Hip Dysplasia Feasibility Study
Dynamic lycra garments are deployed in rehabilitation and exercise to support unstable areas of the body, enhance sensory feedback to improve movement patterns, reduce fatigue and pain and improve function.
- Trial name
- HIPlycra (NCT07438873)
- Testing
- Lycra Shorts
- Volunteers
- 12 people
- Sponsor
- Royal National Orthopaedic Hospital NHS Trust
Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS)
Regenerative Medicine for Joint Hypermobility and Instability
This clinical trial is designed to evaluate whether a stepwise injection-based treatment approach can reduce pain and improve function in adults with joint hypermobility, connective tissue laxity, and joint instability.
- Conditions
- Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint Instability
- Trial name
- NCT07688096
- Testing
- Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational)
- Volunteers
- 100 people
- Sponsor
- Manhattan Pain Medicine, PLLC
Ehlers-Danlos Syndrome
Origins and Impact of EDS in Connective Tissues and Skin
Ehlers-Danlos Syndrome (EDS) is an inherited disease of collagen, found in connective tissues, such as skin. EDS patients suffer from joint and skin problems (skin hyperextensibility, joint hypermobility) along with a large range…
- Trial name
- NCT02721797
- Testing
- Orthopaedic & Gynaecology surgery
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Hypermobility Syndrome
Evaluation of Balance and Physical Performance Under Dual Task Conditions in Individuals With and Without Generalized Joint Hypermobility
This study aims to evaluate balance and physical performance under dual task conditions in individuals with and without Generalized Joint Hypermobility (GJH), as determined by the Beighton score.
- Trial name
- NCT07044999
- Testing
- no intervention
- Volunteers
- 2 people
- Sponsor
- Beylikduzu State Hospital
Benign Hypermobility Syndrome, Functional Constipation
The Comorbidity of Benign Hypermobility Joint Syndrome and Functional Constipation in Children
Benign Hypermobility Joint Syndrome is a group of inherited abnormalities in the structure of connective tissues, manifested by disturbances in the proportion of collagen.
- Trial name
- MobCon (NCT02854098)
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Hypermobility Syndrome (Disorder), Ultrasonography
Ultrasonographic Evaluation of the Effects of Different Wrist Positions on the Median Nerve in Patients With Generalized Joint Hypermobility
The aim of this study was to evaluate the effects of different wrist positions (neutral, flexion, extension, and ulnar deviation) on median nerve morphology in patients with generalized joint hypermobility (GJH) using…
- Conditions
- Hypermobility Syndrome (Disorder), Ultrasonography, Median Nerve
- Trial name
- NCT06918613
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Temporomandibular Disorders (TMD), Temporomandibular Pain
Is the Combine Prolotherapy More Effective Than the Traditional Prolotherapy in Patients With Temporomandibular Joint Hypermobility?
1. Diagnosis and Indication You have been diagnosed with temporomandibular joint (TMJ) hypermobility and/or dysfunction, characterized by symptoms such as jaw clicking, locking, pain in the joint area, or difficulty in opening…
- Conditions
- Temporomandibular Disorders (TMD), Temporomandibular Pain, Hypermobility Syndrome (Disorder), Hypermobility, Joint
- Trial name
- NCT07020455
- Testing
- prolotherapy solution of 20% dextrose, Arthrocentesis with ringer solution
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Karadeniz Technical University
Functional Gastrointestinal Disorders
Prevalence of FODMAP Intolerance and JHS in FGID and Association With Microbiome, Dyssynergic Defecation and Dietary Intervention
Irritable bowel syndrome (IBS) is a disorder of gastrointestinal function characterized by abdominal symptoms and pain associated with alterations in bowel habit.
- Trial name
- PreDiMi (NCT03460613)
- Testing
- FODMAP diet
- Where
- Switzerland
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypermobile Ehlers-Danlos Syndrome, Heavy Menstrual Bleeding
Identifying the Determinants of Bleeding and Hypermobility in Patients With Heavy Menstrual Bleeding
In this study, researchers want to learn about the connection between heavy bleeding issues and joint hypermobility (loose joints).
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Heavy Menstrual Bleeding, Hypermobility Syndrome (Disorder)
- Trial name
- NCT05685199
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Hypermobility, Joint, Hypermobility Syndrome
Exercise in Patients With Hypermobile Joints and Knee Pain
Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving…
- Conditions
- Hypermobility, Joint, Hypermobility Syndrome, Knee Discomfort
- Trial name
- HIPEr-Knee (NCT06277401)
- Testing
- Neuromuscular training for the knee, High-load strength training for the knee
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Southern Denmark
Functional Dyspepsia, Joint Hypermobility Syndrome
Assessment of Gastric Motility on Funtional Dyspepsia and Joint Hypermobility Syndrome
Functional dyspepsia (FD) is defined as the presence of gastroduodenal symptoms in the absence of organic disease that is likely to explain the symptoms.
- Trial name
- NCT04279990
- Testing
- No intervention: assessment of GI function
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Low Back Pain, Mechanical, Spinal Stenosis
Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients
Observational study of axial spine pain and hyperflexibility. Patients will receive physical exam maneuvers (traditional straight leg raise, FABER, facet loading as well as Beighton's hypermobility score) and blood / urine /…
- Conditions
- Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical
- Trial name
- Hypermoble (NCT02761928)
- Testing
- Beighton score for hypermobility
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ankle Sprains, Hypermobility Syndrome
Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study
GJL is a risk factor for postoperative recurrent instability following an MBR for CLAI. BPR with suture tape augmentation and anatomic reconstruction may provide more strength and stability.
- Trial name
- NCT05698446
- Testing
- Modified Broström + Suture tape augmentation operation, Anatomic reconstruction operation, Open Modified Broström procedure
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Joint Hypermobility, Ehlers-Danlos Syndrome
Gait Retraining in Patients With Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome
This study evaluates the efficacy of gait retraining with biofeedback in the treatment of neuromusculoskeletal symptoms in patients with Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome.
- Conditions
- Joint Hypermobility, Ehlers-Danlos Syndrome, Hyperextension Knees
- Trial name
- NCT03575182
- Testing
- Gait retraining program
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Joint Hypermobility Syndrome, Sleep
Sleep Characteristics in Infants With Joint Hypermobility
Joint hypermobility is defined as an increased range of motion in one or more joints compared to the normal range. The Beighton Scoring (BS) system is commonly used to distinguish individuals with generalized joint hypermobility…
- Conditions
- Joint Hypermobility Syndrome, Sleep, Infant
- Trial name
- NCT07121179
- Testing
- Beighton Scoring system, Brief Infant Sleep Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Fatigue, Joint Hypermobility Syndrome
Functional and Performance Determinants in Climbers: Examining the Role of Mobility, Stability, and Fatigue Across Proficiency Levels
The primary objective is to understand how motor skills and fatigue affect climbing performance in indoor and outdoor climbers, also comparing elite and amateur climbers.
- Conditions
- Fatigue, Joint Hypermobility Syndrome, Climbing Injuries, Cognitive Fatigue
- Trial name
- NCT06830655
- Testing
- Fatigue Protocol
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
ADHD, Benign Joint Hypermobility Syndrome
Evaluation of Benign Joint Hypermobility and Serum Prolidase Levels in Children Diagnosed With Attention-Deficit/Hyperactivity Disorder (ADHD) Compared to Healthy Controls
This cross-sectional observational study investigates the clinical and biochemical relationship between Attention-Deficit/Hyperactivity Disorder (ADHD) and Benign Joint Hypermobility Syndrome (BJHS) in pediatric patients.
- Conditions
- ADHD, Benign Joint Hypermobility Syndrome, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- NCT07663383
- Where
- Turkey (Türkiye)
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Hypermobility, Joint, Arthralgia
Association Between Hypermobility and Chronic Musculoskeletal Pain
Study hypothesis:- Benign joint hyper mobility syndrome which persists into adulthood is a special type of benign joint hyper mobility which is more likely to predispose to chronic musculoskeletal pain.
- Conditions
- Hypermobility, Joint, Arthralgia, Myofascial Pain Syndromes, Fibromyalgia
- Trial name
- HAMS (NCT01032863)
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)
Congenital Muscle Disease Study of Patient and Family Reported Medical Information
The Congenital Muscle Disease Patient and Proxy Reported Outcome Study (CMDPROS) is a longitudinal 10 year study to identify and trend care parameters, adverse events in the congenital muscle diseases using the Congenital Muscle…
- Conditions
- Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)
- Trial name
- CMDPROS (NCT01403402)
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Cure CMD
Hypermobility Syndrome
The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time
The purpose of the study is to investigate Joint Hypermobility Syndrome (JHS) and its effect on delayed onset muscle soreness (DOMS) and recovery time.
- Trial name
- NCT04934267
- Testing
- Eccentric Exercise for subjects with JHS, Eccentric Exercise for Controls
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology