Clinical trials: Joint Infection
Acute Bacterial Skin and Skin Structure Infection (ABSSSI), Prosthetic Joints Infection (PJI)
Phase 1, Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants
This is a phase 1, single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical trial of single and multiple intravenous doses of TNP-2092 for injection in healthy Chinese participants.
- Trial name
- NCT06394518
- Testing
- TNP-2092 for injection
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics Inc.
Rheumatic Arthritis
Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient
Despite leading cause of morbidity, treatment strategies for Rheumatic diseases are geared almost exclusively toward medical-pharmacological area away from offering the patient the possibility of an interdisciplinary approach to…
- Trial name
- NCT02020668
- Testing
- Physiotherapy, Wait list control
- Where
- India
- Volunteers
- 82 people
- Sponsor
- Macmillan Research Group UK
COVID-19, Myocardial Injury
Joint Use of Electrocardiogram and Transthoracic Echocardiography With Other Clinico-biological Parameters in an Observational Study to Monitor Cardio-vascular Events and Predict Outcomes in Patients Diagnosed With COVID-19
COVID-19 outbreak is often lethal. Mortality has been associated with several cardio-vascular risk factors such as diabetes, obesity, hypertension and tobacco use.
- Conditions
- COVID-19, Myocardial Injury, Myocarditis
- Trial name
- JOCOVID (NCT04320017)
- Testing
- Electrocardiogram, transthoracic echocardiography and clinico-biological parameters in routine care
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Infection, Bacterial
Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty
Periprosthetic infection following shoulder arthroplasty is a devastating complication. Diagnosing and treating periprosthetic shoulder infection poses a significant challenge.
- Trial name
- Electrocautery (NCT04608916)
- Testing
- Using surgical diathermy to make skin incision, Using scalpel blade to make skin incision
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Missouri-Columbia
Hemophilia Arthropathy
COVID-19 Quarantine on Musculoskeletal Status in Hemophilia
Background. The recurrence of hemarthrosis in patients with congenital coagulopathies favors the development of a progressive, degenerative and intra-articular lesion (hemophilic arthropathy) that mainly affects the knees, ankles…
- Trial name
- HemoCov (NCT04491318)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Spondylarthritis, Spondylarthropathies; Spondylitis, Ankylosing
Effects of a Digital Exercise Intervention on Sleep and Physical Activity in Patients With Spondyloarthritis
The goal of this clinical trial is to assess whether a tailored digital Adapted Physical Activity (APA) program can improve physical activity levels and sleep quality in adults diagnosed with spondyloarthritis (SpA).
- Trial name
- ASPIRE (NCT07034404)
- Testing
- Digital Adapted Physical Activity, Control (Standard treatment)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Prosthesis and Bone Infections, Cutibacterium Acnes
Cutibacterium Acnes in Bone and Joint Infections
Prosthetic Joint Infections (PJIs) are increasing with the use of orthopedic devices on an ageing population. Cutibacterium acnes is a commensal organism that plays an important role in the ecosystem healthy human skin, yet this…
- Trial name
- CaBJI (NCT03950063)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Chronic PJIs
Heraeus MicroDTTect Lyon Pilot Studyprosthetic Joint Infections (PJIs)
Prosthetic joint infections (PJIs) are one of the main causes of implant failure after joint arthroplasty. Identification of the causal organism is crucial for successful treatment.
- Trial name
- NCT04371068
- Testing
- Culture of removed prosthesis using DTT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Surgical Site Infection, Surgical Wound Infection
Floraseal Versus Iodine Impregnated Adhesive Drapes
Infection after total joint arthroplasty can have devastating consequences. Adhesive drapes have been traditionally used at our institution to help reduce the risk of wound contamination and infection by superficial skin flora.
- Trial name
- NCT03466489
- Testing
- Floraseal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Joint Prosthesis; Complications, Infection or Inflammation
Natural Course of Homocysteine After Uneventful Total Joint Arthroplasty
The goal of this observational study is to asses the natural course of blood homocysteine levels in patients who underwent primary total joint arthroplasty surgery.
- Trial name
- NCT05990816
- Testing
- Blood works for homocysteine levels
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Bone Infection, Joint Infection
Performances of DendrisCHIP®OA in Bone and Joint Infections
Bone and joint infections (BJI) with and without prosthetic material (knee, hip and shoulder) are complex to diagnose and treat, justifying the creation of expert centers by the French Ministry of Health (CRIOAc).
- Conditions
- Bone Infection, Joint Infection, Molecular Diagnostic
- Trial name
- DENDRIS (NCT06132347)
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polymyalgia Rheumatica, Inflammatory Rheumatism
Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)
Pseudo-rheumatoid arthritis (PRA) is a common inflammatory rheumatic disease of the elderly, characterized by inflammatory shoulder and/or hip pain.
- Trial name
- JADORE (NCT07132164)
- Testing
- biobank sample collection
- Where
- 30 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Spondylitis, Ankylosing
Blocking Tumor Necrosis Factor in Ankylosing Spondylitis
The Division of Rheumatology at University of California San Francisco is conducting a research study on the treatment of ankylosing spondylitis (AS) with a new therapy currently used for people with other forms of arthritis.
- Trial name
- NCT00000433
- Testing
- Anti-Tumor Necrosis Factor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Prosthetic-joint Infection, Knee Infection
Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection
In the US, if an infection in an artificial knee joint doesn't heal with antibiotics alone, the standard treatment is a two-stage revision of the artificial knee.
- Conditions
- Prosthetic-joint Infection, Knee Infection, Arthroplasty Complications, Joint Infection
- Trial name
- NCT06293352
- Testing
- All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Northwestern University
Prosthetic Joint Infection, Prosthetic Infection
Calprotectin in Chronic Prosthetic Joint Infection
A bacterial infection of an artificial joint is a serious complication that often requires additional surgery to exchange the arthroplasty.
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Arthroplasty Complications
- Trial name
- NCT05060952
- Testing
- Calprotectin Lateral Flow Test
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Tuberculosis, Bone
Phase II Clinical Study of Contezolid for the Treatment of Bone and Joint Tuberculosis
Contezolid is a novel oxazolidinone antibacterial agent that has shown promising application prospects in the field of tuberculosis treatment in recent years.
- Conditions
- Tuberculosis, Bone, Joint
- Trial name
- NCT06811012
- Testing
- Contezolid, Linezolid (LZD)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Chest Hospital
Influenza, Human, Arthralgia
An Intravenous (IV) Zanamivir Pharmacokinetics (PK) Study in Hospitalized Neonates and Infants With Influenza Infection
Influenza infection is an important public health priority, with seasonal outbreaks and pandemics causing considerable global morbidity and mortality.
- Trial name
- NCT04494412
- Testing
- Zanamivir
- Where
- 6 sites in Italy, Poland and 1 more
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor
This is a Phase I/IIa, randomized, double-blind, placebo-controlled, dose-escalation clinical trial to test the candidate vaccine StreptInCor.
- Conditions
- Rheumatic Heart Disease, Rheumatic Heart Disease in Children, Vaccine Adverse Reaction, Rheumatic Diseases
- Trial name
- StreptInCorVac (NCT07078357)
- Testing
- StrepIncor
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bone and Joint Prosthetic Infections
BJI Inoplex 2 : Test for Diagnosis of Prosthetic Infections
A national, prospective, open-label, non-interventional, multicentre, controlled study designed to evaluate a diagnostic method in patients undergoing hip, knee or shoulder prosthetic removal regardless of whether or not…
- Trial name
- NCT02222792
- Where
- 2 sites in France
- Volunteers
- 540 people
- Sponsor
- Diaxonhit