Clinical trials: Joint Pain
Musculoskeletal Pain
A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers
This phase 1 study is to evaluate the safety and pharmacokinetic drug interactions of DHP2306R1 and DHP2306R2 when administered alone and in combination in healthy conditions.
- Trial name
- NCT06395155
- Testing
- DHP2306R1, DHP2306R2
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Daehwa Pharmaceutical Co., Ltd.
Osteoarthritis, Rheumatoid Arthritis
Web-based Support to Manage Arthritis Pain
Development of an interactive, online pain self-management program for adults who suffer from pain associated with osteoarthritis, rheumatoid arthritis, Ankylosing spondylitis, and other arthritic conditions (e.g., psoriatic…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Other Arthritic Conditions (e.g., Psoriatic Arthritis)
- Trial name
- NCT01463189
- Testing
- painACTION: Arthritis
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Inflexxion, Inc.
Gout, Acute Gout Flare
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ABP-745 Administration in Healthy Volunteers
A randomized, double-blind, placebo-controlled, dose-escalation study will be conducted in healthy volunteers. This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ABP-745 following single (Part 1) and…
- Conditions
- Gout, Acute Gout Flare, Gout Flares
- Trial name
- ABP-745 (NCT06258213)
- Testing
- ABP-745
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Atom Therapeutics Co., Ltd
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Shoulder Pain
Liposomal Bupivacaine (Exparel ® ) Plus 0.5% Bupivacaine HCL Versus 0.5% Bupivacaine HCL for Interscalene Nerve Block (ISB) for Patients Undergoing Total Shoulder Arthroplasty(TSA)
This is a phase IV , randomized, single-blind, single-center study comparing patient related outcomes such as postoperative pain and opioid usage for patients who receive ISB 's containing liposomal bupivacaine (Exparel®) plus…
- Trial name
- NCT03913091
- Testing
- Liposomal Bupivacaine, 0.5% Bupivacaine HCL
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hemophilia Arthropathy
COVID-19 Quarantine on Musculoskeletal Status in Hemophilia
Background. The recurrence of hemarthrosis in patients with congenital coagulopathies favors the development of a progressive, degenerative and intra-articular lesion (hemophilic arthropathy) that mainly affects the knees, ankles…
- Trial name
- HemoCov (NCT04491318)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
TMJ Disc Disorder, TMJ Pain
MDR-JuggerKnot Mini Soft Anchor in Maxillofacial TMJ
The objective of this retrospective consecutive series PMCF study is to collect data confirming safety, performance and clinical benefits of the JuggerKnot Mini Soft Anchor (implant and instrumentation) when used for soft tissue…
- Conditions
- TMJ Disc Disorder, TMJ Pain, TMJ Sounds on Opening/Closing the Jaw, TMJ Disease
- Trial name
- NCT04033692
- Testing
- JuggerKnot Mini Soft Anchor
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis
Comparison of Anesthetic Techniques on Total Hip Arthroplasty
To compare analgesia and orthopedic rehabilitation milestones in patients receiving either spinal anesthesia (local anesthetic plus opioid) or general endotracheal anesthesia with lumbar plexus block.
- Trial name
- NCT01359865
- Testing
- Lumbar Plexus Block
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Knee Osteoarthritis
The Effectiveness of Ultrasound Guided Ozone (O2-O3) Injection With Knee Osteoarthritis
Knee ostheoarthritis (KOA) is a common disabling and degenerative disease leading to painful joints, articular stiffness, and decreased function.
- Trial name
- NCT04830423
- Testing
- Medical ozone injection, steroid injection group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Temporomandibular Disorder, Myofascial Pain
Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD
Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD
- Conditions
- Temporomandibular Disorder, Myofascial Pain, Cannabis, Electromyography
- Trial name
- NCT03994640
- Testing
- Cannabis Cream
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Cervical Proprioceptive Error in Healthy Young Individuals
Proprioceptive Puzzle: Effects on Quantitative Sensory Tests and Body Awareness
Background: Cervical proprioception, referring to the awareness of the head's position in space, plays a crucial role in maintaining postural control and preventing musculoskeletal injuries.
- Trial name
- NCT06559397
- Testing
- Assessment of cervical proprioception
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nagihan Acet
Degenerative Joint Disease
Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty
To compare two methods of post-operative pain management in patients undergoing total hip arthroplasty. There is a perception that the periarticular injections may not be as effective in controlling post-operative pain.
- Trial name
- DA THA pain (NCT02904993)
- Testing
- L2 paravertebral block, periarticular injection group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anterior Knee Pain Syndrome
Efffectiveness of a Roller Intervention in Anterior Knee Pain
Anterior knee pain is one of the most frequent reasons for consultation within knee conditions in adolescents and young adults. However, despite the high prevalence of this disorder, its pathogenesis and therefore its treatment…
- Trial name
- NCT03620799
- Testing
- Manual therapy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Injuries, Patellofemoral Pain Syndrome
Effect of Strength and Coordination Training on Biomechanics and Injury in New Runners
The investigators hypothesize that new runners participating in an 8 week strength and coordination training program prior to beginning to run will 1) display different coordination patterns , and 2) experience fewer injuries…
- Conditions
- Injuries, Patellofemoral Pain Syndrome, Iliotibial Band Syndrome
- Trial name
- NCT03293121
- Testing
- Strength and Coordination Training, Walking
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Bilateral Primary Osteoarthritis of Knee
Use of Autologous Bone Marrow Aspirate Concentrate in Painful Knee Osteoarthritis
The overall goal of this study is to develop regenerative cell therapy for use in patients with osteoarthritis (OA). The primary objective of this proposal is to conduct a pilot study that assesses the safety and feasibility of…
- Trial name
- BMAC (NCT01931007)
- Testing
- Autologous Bone Marrow Aspirate Concentrate, Sterile saline
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Shoulder Pain
Range of Motion, Humeral Retroversion and Rotator Cuff (RC) Muscle Strength of the Shoulder in Overhead Athletes
Shoulder pain and dysfunction are common problems in overhead sports, due to extreme ranges of motion and repetitive loading. Predisposing factors include inadequate range of motion (ROM), such as a reduction in total ROM or a…
- Trial name
- NCT02024893
- Testing
- Observational study
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wingate Institute
Shoulder Pain
Physical Therapy Program for Prevention of Shoulder Pain After Device Implant
This is a clinical research study to determine if a prescribed physical therapy intervention after subcutaneous implantation of an implanted cardioverter-defibrillator (ICD) or pacemaker reduces the incidence of rotator cuff…
- Trial name
- NCT00680537
- Testing
- Exercises
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Temporomandibular Disorder
Analgesic Effects of LED Light on Temporomandibular Disorders.
Low intensity laser therapy (LILT) has been widely applied in pain relief in several clinical situations. With the advent of new LED-based (light emitting diode) light sources, the need of further clinical experiments aiming to…
- Trial name
- LED/TMD (NCT01873937)
- Testing
- Red LED, INFRARED LED, LASER
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Anesthesia, Pain, Postoperative
Ultrasound Guided Repositioning of a New Suture-Method Catheter for Adductor Canal Block
This is a randomized clinical trial in healthy volunteers. 12 volunteers will have suture-method catheters placed in the adductor canal of each leg using the long-axis plane and short-axis plane technique.
- Conditions
- Anesthesia, Pain, Postoperative, Pain, Pain, Joint
- Trial name
- NCT03315481
- Testing
- SAX catheter insertion, LAX catheter insertion
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Patellofemoral Osteoarthritis
Effect of Hip and Core Muscle Strengthening for Patellofemoral Osteoarthritis: A Feasibility Study
The purpose of this research is to develop and test the feasibility of an exercise intervention for persons with painful knee osteoarthritis involving the patella (kneecap).
- Trial name
- NCT02825238
- Testing
- Supervised exercise program
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of the Sciences in Philadelphia