Clinical trials: Joint Replacement
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Temporomandibular Joint
Tempromandibular Joint Reconstruction Via Computer-Assisted Surgery Simulation
This study was planned to evaluate the accuracy of virtual surgical planning and three-dimensional (3D) printed templates in reconstruction of temporomandibular joint (TMJ) with costochondral graft.
- Trial name
- NCT06811415
- Testing
- virtual temporomandibular joint reconstruction with costochondral graft
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Tanta University
Arthroplasty, Replacement
Wound Additives in Primary Total Joint Athroplasty
3 cohorts of total joint patient of 30 members each were randomized to receive PRP or Activated Collegen or no additive were studied for status of the wound at 6 weeks and recorded all complications, infections and reoperations.
- Trial name
- NCT03158623
- Testing
- Platelet Rich Plasma, Cellerate
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Salt Lake Orthopedic Clinic
Hip Dysplasia
The Influence of Hip Replacement on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient
Explore the influence of hip replacement on lower extremity hemodynamics in Crowe Ⅳ hip dysplasia patient.
- Trial name
- NCT04157842
- Testing
- total hip replacement with subtrochanteral osteotomy, total hip replacement with no osteotomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Orthopedic, Osteo Arthritis Knee
Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes
The proposed project is novel in its goal to establish a foundation for evidence-based rehabilitative nutrition guidelines to enhance perioperative patient care and improve post-operative rehabilitative outcomes specific to…
- Conditions
- Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition
- Trial name
- ESPI-PRO (NCT06734845)
- Testing
- Total Knee Arthroplasty, Total Joint Arthroplasty
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Arthroplasties, Replacement, Weight Loss
Weight Loss Before Total Joint Arthroplasty Using A Remote Dietitian and Mobile App
The purpose of this trial is to assess the impact of a 12-week remote dietitian supervised dietary and physical activity weight loss intervention and mobile app for patients with morbid obesity prior to undergoing total joint…
- Conditions
- Arthroplasties, Replacement, Weight Loss, Nutrition
- Trial name
- NCT04330391
- Testing
- Remote dietitian supervised weight loss intervention and mobile app
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
Persona MC vs Attune Total Knee Replacement Study
This study aims to compare clinical and functional outcomes of a cohort of patients that have undergone a medial congruent TKR to a similar cohort of patients that have undergone a conventional TKR and a cohort of control…
- Trial name
- PERTUNE (NCT03580772)
- Testing
- Persona TKR, Attune TKR
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Osteoarthritis
Medacta GMK Sphere® Multicenter Post-Market Outcomes Study
This study is to average Forgotten Knee Score (FJS) of those patients receiving the Medacta GMK Sphere® knee at the two and five year time points.
- Trial name
- NCT02501733
- Testing
- Medacta GMK Sphere® Medial Knee Prosthesis
- Where
- 5 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Knee Osteoarthritis, Knee Arthritis
Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty
Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT03302832
- Testing
- Physical Therapy, In-home Exercise Equipment
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Shoulder Arthroplasty
Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants
The purpose of this study is to determine whether the use of plain bupivacaine with common adjuvants for interscalene block (ISB) provides non-inferior analgesic results compared to the use of liposomal bupivacaine for ISB, in…
- Trial name
- NCT03845894
- Testing
- Liposomal bupivacaine, Bupivacaine with adjuvants
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis
RSA Study of Sirius Stem and Exceed Cup
The purpose of this study is to evaluate the efficacy and safety of the Sirius Cemented Stem used in conjunction with the Exceed ABT Cemented Acetabular Cup, either with E1 or Arcom polyethylene, and OptiPac/OptiVac bone cement…
- Trial name
- NCT02307331
- Testing
- Optivac, Optipac, Arcom (Exceed cup)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Region Skane
Osteoarthritis, Femoral Head Necrosis
Donepezil Attenuate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Osteoarthritis, Femoral Head Necrosis, Rheumatoid Arthritis
- Trial name
- DAPOCD (NCT02927522)
- Testing
- Donepezil
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Pain Measurement, Knee Replacement Arthroplasty
Anterior Cutaneus Nerve and Distal Adductor Canal Block With USG for Total Knee Replacement Analgesia
This prospective clinical study was approved by the institutional ethics committee on September 27, 2023, and patient enrollment started in October 2023.
- Conditions
- Pain Measurement, Knee Replacement Arthroplasty, Nerve Block
- Trial name
- NCT06201195
- Testing
- Adductor canal blockade, Distal adductor canala blockade and anterior cutaneus nerve blockade
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Osteoarthritis
The Use of Compression Bandages in Total Knee Replacement Surgery
The use of compression bandages in elective orthopaedic knee surgery is well regarded, however, there is a lack of robust, well-designed evidence to support this.
- Trial name
- NCT02253680
- Testing
- Actico, short-stretch, inelastic dressing
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Osteoarthritis, Knee
Navio Robotic Versus Conventional Total Knee Arthroplasty
Total knee replacement surgery is a conventional approach to alleviating the pain and lack of function resulting from arthritis of the knee.
- Trial name
- NCT03519269
- Testing
- Navio™ Robotics-assisted Surgical System
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis, Knee
Postoperative Drainage in Total Knee Arthroplasty in the Presence of Tranexamic Acid
The investigator's aim with this study is to address, with the new paradigm of tranexamic acid, the role of wound drainage following total knee arthroplasty in blood loss, blood transfusion requirements and functional recovery
- Trial name
- NCT03915756
- Testing
- Drainage of surgical wound
- Where
- Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Osteoarthritis, Knee
Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
The aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (PS) rotating-platform mobile-bearing (RP-MB) total knee arthroplasty.
- Trial name
- NCT00954954
- Testing
- Standard PS RP-MB (P.F.C Sigma Rotating Platform knee), High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
- Where
- South Korea
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital