Clinical trials: Joint Replacement
Osteoarthritis of the Knee
Total Knee Replacement Study Using Standard Cutting Guide vs Otismed MRI Generated Cutting Guide
Patients are referred to the VA orthopedic surgical clinic because of osteoarthritis and are requesting consideration for a total knee replacement. Those who qualify for the knee replacement are informed about the study.
- Trial name
- NCT00837772
- Testing
- Standard cutting guide for TKA, Otismed MRI generated cutting guide for TKA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Phoenix VA Health Care System
Osteoarthritis
The Use of Compression Bandages in Total Knee Replacement Surgery
The use of compression bandages in elective orthopaedic knee surgery is well regarded, however, there is a lack of robust, well-designed evidence to support this.
- Trial name
- NCT02253680
- Testing
- Actico, short-stretch, inelastic dressing
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Osteoarthritis, Total Knee Arthroplasty
Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty
Does the use of periarticular Exparel in total knee arthroplasty prove to more effectively manage post operative pain control than another local analgesic, Ropivacaine, when both are used as part of a multimodal pain management…
- Conditions
- Osteoarthritis, Total Knee Arthroplasty, Pain Management
- Trial name
- NCT02808728
- Testing
- Pain Cocktail with Exparel, Pain Cocktail with Ropivacaine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DeClaire LaMacchia Orthopaedic Institute
Degenerative Joint Disease, Osteoarthritis
Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery
This study is to determine the relevancy of clinical scales for outcome measures as compared to flexion angle and other gait measures.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder
- Trial name
- TKR (NCT01379118)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Total Knee Arthroplasty, Total Knee Replacement
ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System
The cementless ATTUNETM Rotating Platform Knee system was compared in a single-blind, randomized RSA trial to its predecessor, the LCS rotating platform Knee System.
- Conditions
- Total Knee Arthroplasty, Total Knee Replacement, Knee Osteoarthritis
- Trial name
- NCT05623215
- Testing
- Radiographs of the knee for radiostereometric analysis (RSA)
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Spaarne Gasthuis
Knee Osteoarthritis
Persona MC vs Attune Total Knee Replacement Study
This study aims to compare clinical and functional outcomes of a cohort of patients that have undergone a medial congruent TKR to a similar cohort of patients that have undergone a conventional TKR and a cohort of control…
- Trial name
- PERTUNE (NCT03580772)
- Testing
- Persona TKR, Attune TKR
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Osteoarthritis, Pain
Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
The purpose of this study is to determine if full weight bearing following total hip replacement can speed recovery when the hip replacement in the long bone of the leg is not cemented into the bone.
- Trial name
- NCT00179088
- Testing
- Patient may be able to put weight on the operated leg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ankle Arthroplasty, Prosthesis User
3D X-ray Motion Analysis of Ankle-foot Motion After Total Ankle Arthroplasty
Patients who have had a total ankle joint replacement surgery typically have limited movement in their ankles possibly due to the fact that commonly used ankle joint prosthetic devices only allow limited axes of motion.
- Conditions
- Ankle Arthroplasty, Prosthesis User, Joint Disease
- Trial name
- NCT03575975
- Testing
- Total Ankle Replacement Prosthesis
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Mild Cognitive Impairment
Preoperative Cognitive Screening of Surgical Patients 65 Years of Age or Older
The overall objectives of this study are to improve outcomes of surgical patients 65 years of age or older through risk stratification based on preoperative screening of cognition / mental function.
- Trial name
- NCT02570451
- Testing
- Patient Survey, Mini Cog, Independent Activities of Daily Living Score Sheet
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Arthroplasty, Replacement
Wound Additives in Primary Total Joint Athroplasty
3 cohorts of total joint patient of 30 members each were randomized to receive PRP or Activated Collegen or no additive were studied for status of the wound at 6 weeks and recorded all complications, infections and reoperations.
- Trial name
- NCT03158623
- Testing
- Platelet Rich Plasma, Cellerate
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Salt Lake Orthopedic Clinic
Osteoarthritis, Sarcopenia
The Strong Brain Study
To evaluate operational aspects of studying pre to post surgery/hospitalization changes in the integrity of a major white matter pathways and how these contribute to reductions in the ability to produce forceful muscle…
- Trial name
- NCT02320864
- Testing
- Total knee replacement surgery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Arthroplasty, Replacement
Walking Stick Exercise in Patients Underwent Total Knee Arthroplasty
The purpose of this study is to examine whether the effect of "hiking poles exercise" on lower extremity muscular strength, knee range of motion, and quality of life in elderly patients underwent total knee arthroplasty
- Conditions
- Arthroplasty, Replacement, Knee Osteoarthritis
- Trial name
- NCT05030662
- Testing
- Walking stick exercise
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Orthopedic, Osteo Arthritis Knee
Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes
The proposed project is novel in its goal to establish a foundation for evidence-based rehabilitative nutrition guidelines to enhance perioperative patient care and improve post-operative rehabilitative outcomes specific to…
- Conditions
- Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition
- Trial name
- ESPI-PRO (NCT06734845)
- Testing
- Total Knee Arthroplasty, Total Joint Arthroplasty
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Degenerative Joint Disease
Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty
To compare two methods of post-operative pain management in patients undergoing total hip arthroplasty. There is a perception that the periarticular injections may not be as effective in controlling post-operative pain.
- Trial name
- DA THA pain (NCT02904993)
- Testing
- L2 paravertebral block, periarticular injection group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoarthritis, Post-Traumatic Arthritis
Study of the Scandinavian Total Ankle Replacement (STAR) for the Treatment of Bilateral Degenerative Ankle Disease
The purpose of this study is to evaluate the safety of the S.T.A.R. device for patients with bilateral disease.
- Conditions
- Osteoarthritis, Post-Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT00586781
- Testing
- Scandinavian Total Ankle Replacement (STAR)
- Where
- 5 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Link America, Inc.
Arthritis
Sexual Function Questionnaire Total Hip Replacement
Non-commercial trial 2 Centres involved: University Hospital Southampton and Spire Southampton Expected number of eligible participants available per year: 100, (95% expected to agree to participation) The study will recruit…
- Trial name
- NCT02290652
- Testing
- Prospective - Factors affecting sexual function pre-THR, Retrospective- Factors affecting sexual function post-THR
- Where
- 2 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Osteoarthritis, Degenerative Joint Disease
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement
The purpose of this study is to clarify the efficacy of a multidrug versus single drug periarticular injection when only standard operative and postoperative pain management protocols used and the control group is exposed to what…
- Trial name
- NCT03119038
- Testing
- Bupivicaine + epinephrine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Postoperative Delirium
Protocol for Observational Study of Post op Delirium Following Total Joint Arthroplasties
The incidence of post-operative delirium in the South-east Asian population is not known. Through a prospective, single centre, observational study, the investigators aim to characterize the incidence and risk factors of delirium…
- Trial name
- NCT03260218
- Where
- Singapore
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Arthroplasty, Replacement, Knee, Acute Kidney Injury
After Surgery Acute Renal Failure Incidence in Total Knee Arthroplasty With and Without Tourniquet
This study analize the incidence of acute renal failure after performing total knee arthroplasty with or without use of tourniquet limb cuff (half of patients for each group) in a randomized clinical trial
- Conditions
- Arthroplasty, Replacement, Knee, Acute Kidney Injury, Tourniquets, Knee Osteoarthritis
- Trial name
- NCT03795805
- Testing
- total knee arthroplasty, Tourniquet limb cuff, Intaarticular lidocain
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social