Clinical trials: Joint Replacement, open to volunteers
Rheumatoid Arthritis, Osteoarthritis Shoulder
Tornier HRS (Humeral Reconstruction System) Study (REVIVE)
This is an international, single arm, multicenter, prospective follow-up, non-significant risk, Post-Market Clinical Follow-up (PMCF) study.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis Shoulder, Fractures Humerus, Avascular Necrosis
- Trial name
- REVIVE (NCT05500066)
- Testing
- Tornier HRS (HUMERAL RECONSTRUCTION SYSTEM) shoulder system
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis
ARVIS TKA vs Conventional TKA
This study is a pilot analysis of a novel augmented reality guidance platform, the augmented reality visualization and information system (ARVIS, Insight Medical), with aims to demonstrate accuracy of bone resection and implant…
- Trial name
- ARVIS (NCT06663384)
- Testing
- Evaluation of Augmented Reality technology in TKA compared to standard TKA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Foundation for Orthopaedic Research and Education
PROMs, Total Ankle Replacement
Validation of the Italian Version of the Forgotten Joint Score (FJS-12) in Total Ankle Replacement
The arthritic pathology of the tibio-tarsal joint has a prevalence of approximately 1% in the general population, and its incidence has been increasing over the years.
- Conditions
- PROMs, Total Ankle Replacement, Italian Forgotten Joint Score
- Trial name
- NCT06091397
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis, Knee, Joint Diseases
Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty
Randomized, controlled, single center observational study to compare the safety and performance of navigation-assisted OrthoPilot Elite and robotic-assisted MAKO total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Joint Diseases, Rheumatoid Arthritis of Knee, Posttraumatic Arthropathy
- Trial name
- ORMAK (NCT05980442)
- Testing
- Navigated total knee arthroplasty, Robot assisted total knee arthroplasty
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Aesculap AG
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Artificial Intelligence (AI), Machine Learning
Development and Pre-validation of a Machine Learning-based Prediction Algorithm for Early Functional Recovery in Patients Undergoing Hip and Knee Replacement Surgery
The goal of this observational study is to develop and pre-validate a machine learning algorithm to predict early recovery of mobility in patients undergoing hip or knee joint replacement surgery.
- Conditions
- Artificial Intelligence (AI), Machine Learning, Joint Replacement, Predictive Model
- Trial name
- FISIO_IA (NCT07333560)
- Testing
- Predictive Model for Early Mobility Recovery and Length of Stay
- Where
- 2 sites in Italy
- Volunteers
- 943 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis, Degenerative Joint Disease of the Knee
Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types
This study aims to evaluate patient outcomes following robotic-assisted total knee arthroplasty using the VELYS system. Patients undergoing surgery will receive either kinematic alignment or functional alignment as determined by…
- Trial name
- VELYS RCT (NCT07533188)
- Testing
- Medial Stabilized Insert, Cruciate Retaining Insert
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- Singapore General Hospital
Arthroplasty, Replacement
SMR Stemless Reverse vs SMR Reverse Shoulder System
The SMR Stemless Reverse is intended for total, primary shoulder joint replacement by reducing pain and restoring shoulder articular mobility function.
- Trial name
- NCT04697004
- Testing
- Investigational Arm: SMR Stemless Reverse, Control Arm: SMR Reverse Shoulder System
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis (OA) of the Knee, Total Knee Anthroplasty
Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA
Knee osteoarthritis is a growing socioeconomic burden because of the ageing and obesity. By 2030, the majority of individuals undergoing knee arthroplasty in USA will be those younger than 65 years, with up to 1 million achieved…
- Trial name
- rKA-KA-TKA (NCT06726993)
- Testing
- Total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Assiut University
Knee Arthroplasty, Total, Knee Replacement Arthroplasty
Remote Monitoring After Knee Replacement Surgery
The goal of this clinical trial is to evaluate the effect, cost-effectiveness, safety and satisfaction with replacing standardized, pre-scheduled face-to-face visits with remote monitoring and video consultations or face-to-face…
- Trial name
- OA-AID TKR (NCT07003932)
- Testing
- Remote monitoring, Usual Care
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Diakonhjemmet Hospital
Arthropathy of Knee, Arthropathy of Hip
Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery.
- Conditions
- Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
- Trial name
- NCT05381818
- Testing
- Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Arthropathy, Knee Replacement
The Medacta GMK SpheriKA Post-Marketing Surveillance Study
This is a Post-Marketing Surveillance of GMK SpheriKA knee stem prosthesis.
- Trial name
- NCT05459948
- Testing
- GMK SpheriKA
- Where
- 4 sites in France, Italy and 1 more
- Volunteers
- 281 people
- Sponsor
- Medacta International SA
Osteoarthritis
A Study on Rosa Roxburghii for Knee Replacement Recovery
This clinical trail is to investigates the effect of Rosa roxburghii juice freeze-dried powder on the recovery of patients undergoing total knee arthroplasty due to knee osteoarthritis.
- Trial name
- NCT07395856
- Testing
- Rosa roxburghii
- Volunteers
- 184 people
- Sponsor
- Shuguang Gao
Surgical, Anxiety
Virtual Reality Therapy to Improve Arthroplasty Outcomes
Virtual reality (VR) has recently emerged as a non-medication-based method to manage anxiety. The patient wears a VR headset and is offered an immersive environment with hypnotic components with sound and imagery in a 3D…
- Conditions
- Surgical, Anxiety, Pain Management, Joint (Knee or Hip Replacement)
- Trial name
- VROOM (NCT07872670)
- Testing
- Virtual Reality Headset, Blood Samples, Questionnaires
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Highland Research, Development and Innovation Organisation
Osteoarthritis of Hip
Hip Replacement System (HRS-P) in Primary Total Hip Arthroplasty
To evaluate effectiveness and safety of HHRS in subjects undergoing total hip arthroplasty (THA). Effectiveness will be evaluated using patient-reported, clinical, radiologic, and radiostereometric outcomes.
- Trial name
- (HRS-P) (NCT02836262)
- Testing
- HIT Hip Replacement System
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hip Innovation Technology
Hip Osteoarthritis, Arthroplasty, Replacement, Hip
Preoperative Fasting and the Gut Microbiome Before Hip Replacement
Postoperative complications occur in 5-15% of patients undergoing elective primary total hip arthroplasty (THA), including periprosthetic joint infection (PJI), thrombosis, wound healing disorders, and metabolic dysregulation.
- Conditions
- Hip Osteoarthritis, Arthroplasty, Replacement, Hip, Postoperative Complications, Surgical Wound Infection
- Trial name
- PreFAST-Hip (NCT07651462)
- Testing
- Buchinger Fastenbox + intermittent fasting (20-day preoperative schedule)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Charite University, Berlin, Germany
Knee Osteoarthritis
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis.
- Trial name
- NCT04275362
- Testing
- DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- More Foundation
Knee Osteoarthristis, Arthroplasties, Knee Replacement
Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty
The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to…
- Trial name
- NCT07319546
- Testing
- Accelerated exercise, Routine exercise
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Mahidol University
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\)
Suzetrigine in Total Hip Arthroplasty
Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery
- Trial name
- NCT07226700
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York