Clinical trials: Joint Replacement
Osteoarthritis
Comparison of the Tibiofemoral Rotational Alignment After Mobile and Fixed Bearing Total Knee Arthroplasty
The anatomic landmark for the anteroposterior (AP) axis of the proximal tibia and its variability was investigated in this study in order to determine whether a certain landmark could be employed as a reference axis for the…
- Trial name
- NCT01751334
- Testing
- total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs.
- Trial name
- TWEAK (NCT02628795)
- Testing
- PRT + FM, Usual Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Degenerative Joint Disease
The Study of Physical Activity Rewards After Knee Surgery
The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH).
- Trial name
- SPARKS (NCT01970631)
- Testing
- Motivational Interviewing (MI), Financial Incentives
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Brigham and Women's Hospital
Hip Osteoarthritis, Indication for Total Hip Replacement
Evaluation of Locomotor Activity Before and After Total Hip Replacement in Patients With Hip Osteoarthritis.
The investigators believe that the application of non-linear methods of analysis using the ganglion and neural network technique will make it possible to analyse all of the complex data obtained in patients with hip…
- Trial name
- NCT02042586
- Testing
- Analysis of movement before total hip replacement, Analysis of movement after total hip replacement
- Where
- France
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Knee Osteoarthritis, Pressure Ulcer
Pressure Ulcers in Knee Replacement Surgery
From the point of view of nursing to know exactly the different risk factors for the onset of pressure ulcers is very important as it allows to accurately orient preventive care interventions.
- Trial name
- peripress (NCT03039153)
- Where
- Italy
- Volunteers
- 565 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis Arthritis, Joint Diseases
Persona Versus NexGen
The NexGen TKR (Zimmer, Warsaw, Indiana, USA) is a proven TKR design that has reported excellent medium and long-term results in clinical studies and in implant registries all around the world.
- Conditions
- Osteoarthritis Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- NCT02269254
- Testing
- Persona PS Knee Prosthesis by Zimmer, NexGen PS Knee Prosthesis by Zimmer
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Leiden University Medical Center
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Dimolegin® (60 mg) Given Once Daily in Patients Undergoing Total Hip or Knee Replacement Compared to Enoxaparin
This clinical study aims to evaluate the efficacy and safety of the anticoagulant Dimolegin® compared to low molecular weight heparin (Clexane®) for the prevention of venous thromboembolic events (VTE) in patients undergoing…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Venous Thromboembolism (VTE), Prevention
- Trial name
- NCT07124819
- Testing
- Sodium enoxaparin, Dimolegin
- Where
- 8 sites in Russia
- Volunteers
- 215 people
- Sponsor
- Avexima Diol LLC
Osteoarthritis, Knee, Joint Diseases
Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty
Randomized, controlled, single center observational study to compare the safety and performance of navigation-assisted OrthoPilot Elite and robotic-assisted MAKO total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Joint Diseases, Rheumatoid Arthritis of Knee, Posttraumatic Arthropathy
- Trial name
- ORMAK (NCT05980442)
- Testing
- Navigated total knee arthroplasty, Robot assisted total knee arthroplasty
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Aesculap AG
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Testing Implementation of Total Joint Replacement Rehabilitation Quality Indicator Toolkits
The goal of this feasibility study is to test the procedures for implementing quality indicator toolkits for hip and knee replacement rehabilitation in clinical settings.
- Trial name
- NCT06208553
- Testing
- QI toolkit implementation
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Arthroplasty, Knee
Effect of Body-mass Index (BMI) on Median Effective Dose of Intrathecal Hyperbaric Bupivacaine
The effect of Body-mass index (BMI) on requirements of local anesthetics used in spinal anesthesia has not been well established.
- Trial name
- NCT01291186
- Testing
- BPV6NO, BPV7NO, BPV8NO
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul Medical Center
Consent Forms, Osteoarthritis, Knee
Development, Piloting and Evaluation of an Evidence-based Informed Consent Form for Total Knee Arthroplasty
Every medical intervention requires informed consent. Informed consent may include comprehensible information about the necessity and kind of the intervention, material risks and consequences or alternative treatments.
- Conditions
- Consent Forms, Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- EvAb-Pilot (NCT04669483)
- Testing
- evidence-based informed consent form
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Witten/Herdecke
Hip Osteoarthritis
Progressive Resistance Training Versus Total Hip Arthroplasty in Patients With Hip Osteoarthritis
Hip osteoarthritis is associated with joint pain, physical disability, decreased muscle strength and poor health status, and the most common cause for total hip arthroplasty.
- Trial name
- PROHIP (NCT04070027)
- Testing
- Total Hip Arthroplasty, Progressive Resistance Training
- Where
- 4 sites in Denmark
- Volunteers
- 109 people
- Sponsor
- Vejle Hospital
Arthroplasty, Replacement, Knee
MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence
Following a prosthetic knee joint infection, two types of operative approach can be undertaken to treat the infection: a one-stage or two-stage revision operation.
- Trial name
- MIKROBE (NCT04458961)
- Testing
- One-stage, Two-stage
- Where
- 2 sites in United Kingdom
- Volunteers
- 3 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Musculoskeletal Inflammatory
ARTERIAL EMBOLIZATION OF PERSISTENT GENICULATE ARTERIES FOR CHRONIC PAIN MANAGEMENT AFTER TOTAL KNEE-REPLACEMENT ARTHROPLASTY(KNEE EMBOLISATION)
Recent works in interventional radiology have shown interesting results in the treatment of musculoskeletal inflammatory sites by arterial embolization. Supra-selective arterial embolization has been successfully developed by Dr.
- Trial name
- NCT04417686
- Testing
- arterial embolization
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Knee Osteoarthritis
Pulsed Electromagnetic Field Therapy on Muscle Strength and Function in Patients With End-stage of Knee Osteoarthritis
End-stage OA knee is one of the most common musculoskeletal complaints, with over 34,000 patients waiting for joint replacement in Hong Kong and is expected to increase as the population continues to age constantly.
- Trial name
- NCT06196567
- Testing
- PEMF, exercise
- Where
- Hong Kong
- Volunteers
- 43 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis
Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery
The purpose of this study is to compare two methods of pain control used during total knee joint replacement surgery. The pain medication that will be used for this study is not experimental.
- Trial name
- NCT02106481
- Testing
- Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Eastern Maine Medical Center
Osteoarthritis
Metal Ion Serum Concentrations in Patients With Total Hip Replacements
Other research studies have shown that the levels of metals in the blood are slightly increased after patients receive a total hip replacement.
- Trial name
- NCT00156598
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Osteoarthritis, Post Traumatic Degenerative Disease
Post-Market Study of the EPIK Knee System
The purpose of this study is to determine the short-term (2 yr) and midterm (5 yr) cumulative revision rates of the EPIK™ Uni-compartmental Knee System.
- Trial name
- EPIK (NCT01464632)
- Testing
- EPIK™ uni-compartmental knee
- Where
- United States
- Sponsor
- Encore Medical, L.P.