Clinical trials: Joint Replacement, open to volunteers
Knee Osteoarthritis
Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
Osteoarthritis (OA) is the most common joint disease. It is characterized by a progressive destruction of all the components of the joint, especially the cartilage.
- Trial name
- MOUV-GOPRO (NCT05488093)
- Testing
- X-sens sensor
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis of Hip
Hip Replacement System (HRS-P) in Primary Total Hip Arthroplasty
To evaluate effectiveness and safety of HHRS in subjects undergoing total hip arthroplasty (THA). Effectiveness will be evaluated using patient-reported, clinical, radiologic, and radiostereometric outcomes.
- Trial name
- (HRS-P) (NCT02836262)
- Testing
- HIT Hip Replacement System
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hip Innovation Technology
Prosthetic-joint Infection, Knee Infection
Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection
In the US, if an infection in an artificial knee joint doesn't heal with antibiotics alone, the standard treatment is a two-stage revision of the artificial knee.
- Conditions
- Prosthetic-joint Infection, Knee Infection, Arthroplasty Complications, Joint Infection
- Trial name
- NCT06293352
- Testing
- All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Northwestern University
Knee Osteoarthristis
Sleep TO Prevent Post-surgical Pain
This research study is being done to compare different methods of addressing sleep problems before total knee replacement surgery. These methods include Cognitive Behavioral Therapy and light exposure.
- Trial name
- STOPPP (NCT06976138)
- Testing
- Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- Johns Hopkins University
Arthropathy, Knee Replacement
The Medacta GMK SpheriKA Post-Marketing Surveillance Study
This is a Post-Marketing Surveillance of GMK SpheriKA knee stem prosthesis.
- Trial name
- NCT05459948
- Testing
- GMK SpheriKA
- Where
- 4 sites in France, Italy and 1 more
- Volunteers
- 281 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis
Robotic Assisted Surgery In Total Knee Replacement
The goal of this clinical trial is to compare robotic arm assisted surgery with manual surgery in patients operated with knee replacement.
- Trial name
- NCT05842538
- Testing
- Triathlon
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Sahlgrenska University Hospital
Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee
pDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement
Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of…
- Conditions
- Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture
- Trial name
- pDIFFIR (NCT05805774)
- Testing
- Distal Femur Replacement, Surgical fixation
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Unity Health Toronto
Periprosthetic Joint Infection (PJI)
Molecular Biology in the Identification of Pathogens at Reimplantation in the Two-Stage Treatment of Periprosthetic Infections
The goal of this observational study is to measure the diagnostic accuracy of the Multiplex PCR technique in identifying pathogens during the diagnostic stage of resolving pre-implantation infection, in the context of treatment…
- Trial name
- MOLPJI (NCT06804265)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hip Osteoarthritis, Knee Osteoarthristis
The Outcome of Three Weeks Rehabilitation in Patients With a Total Hip or Knee Replacement Experiencing Persistent Physical Impairments
Patients with total hip or knee replacement experiencing persistant problems are offered 3 weeks of intensive rehabilitation.
- Trial name
- Rehab-hip-knee (NCT07105657)
- Testing
- Rehabilitation
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Horsens Hospital
Temporomandibular Disorders (TMD), Temporomandibular Joint Ankylosis
Virtual Planning of Total Temporomandibular Joint Replacement
A total TMJ replacement surgery is currently planned based on the X-ray appearance of the facial X-ray. It is now possible to use either an individually designed TMJ prosthesis or a prosthesis with a standard appearance.
- Trial name
- NCT07373184
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University Hospital
Total Knee Replacement, Knee Osteoarthritis
Circulatory Exercise After Total Knee Replacement
Total knee replacement is commonly associated with early postoperative inflammation, edema, pain, and reduced mobility. This randomized controlled trial will evaluate whether adding a simple circulatory exercise program to…
- Conditions
- Total Knee Replacement, Knee Osteoarthritis, Postoperative Edema, Postoperative Inflammation
- Trial name
- NCT07688642
- Testing
- standard postoperative TKR rehabilitation, Standard Rehabilitation Plus Circulatory Exercise
- Volunteers
- 68 people
- Sponsor
- Assiut University
Shoulder Arthritis, Shoulder Osteoarthritis
S-11 SMR TT Hybrid Glenoid and Cementless Finned Short Stem
Post-market, prospective, non randomized, open label, multicentre, clinical study analysing outcomes of shoulder arthroplasty with SMR TT Hybrid Glenoid with or without SMR Cementless Finned Short Stem
- Conditions
- Shoulder Arthritis, Shoulder Osteoarthritis, Arthrosis, Osteoarthritis
- Trial name
- NCT05314387
- Testing
- SMR TT Hybrid Glenoid without Cementless Finned Short Stem, SMR TT Hybrid Glenoid with Cementless Finned Short Stem
- Volunteers
- 100 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis, Knee
RSA Restoris MultiCompartmental Knee
Patients with isolated medial compartment arthritis of the knee are commonly treated with unicompartmental knee arthroplasty (UKA).
- Trial name
- NCT05417984
- Testing
- Restoris MCK
- Volunteers
- 33 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Frozen Shoulder, Adhesive Capsulitis
Effect of Hormone Replacement Therapy on Physiotherapy Outcomes in Postmenopausal Women With Frozen Shoulder
The purpose of this study is to compare the effects of a physiotherapy program on pain levels, shoulder range of motion, functional status, pain catastrophizing, perceived change, sleep quality, and quality of life in…
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Adhesive Capsulitis of the Shoulder, Hormone Replacement Therapy, Post-Menopausal
- Trial name
- NCT07736027
- Testing
- Standardized Physiotherapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul University - Cerrahpasa
Knee Replacement, Total
Knee Replacement Rehabilitation Care Pathways
Previous research has shown that use of rehabilitation (including physical therapy) and the recovery of function after knee replacement surgery may differ depending on patients' race, sex, income or insurance, and geographic…
- Trial name
- NCT07598539
- Testing
- TKA Journey - patient education, Optimized Rehab Scheduling, Usual Rehab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Total Knee Replacement, Total Knee Replacement Surgery
Mako Cementless TKA vs Mako Cemented TKA
The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako…
- Conditions
- Total Knee Replacement, Total Knee Replacement Surgery, Total Knee Arthroplasty, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06929871
- Testing
- Mako cementless TKA, Mako cemented TKA
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College, London
Adhesive Capsulitis of the Shoulder, Frozen Shoulder
Frozen Shoulder and Hormone Replacement Therapy
The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle.
- Trial name
- FSHRT (NCT07278323)
- Testing
- Hormone Replacement Therapy (HRT), Corticosteroid and 1%lidocain, physical therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Knee Osteoarthritis, Morbid Obesity
Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Does weight loss surgery in patients with morbid obesity prior to knee replacement surgery improve outcomes from knee replacement surgery
- Trial name
- OMEOSKO (NCT05120492)
- Testing
- bariatric surgery followed by total knee replacement
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet