Clinical trials: Juvenile-Onset Diabetes
Type1diabetes
Very Low Carbohydrate Diets and Glucagon Response in T1DM
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT04200391
- Testing
- Very low carbohydrate diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Type 1
A Study to Compare and Measure the Effects of Insulin Peglispro (LY2605541) and Glargine on Meal Time Insulin Requirements
This study will look into how a base dose of insulin peglispro and insulin glargine will affect the meal time dose and efficacy of insulin lispro in type 1 diabetics.
- Trial name
- NCT02152384
- Testing
- Insulin Peglispro, Insulin Lispro, Insulin Glargine
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Obesity
Prevalence of Overweight and Obesity in Adult Patients Suffering From Type 1 Diabetes
A registry of individuals with type 1 diabetes that visited the Department of Endocrinology of the University Hospitals of Leuven is established.
- Trial name
- POOT1 (NCT05713448)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 100,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes (T1D)
"Perception, Knowledge, and Attitudes of Educational Staff Regarding the Care of Children With Type 1 Diabetes: Evaluation of the Educational Program"
Type 1 diabetes is a chronic autoimmune disease that requires continuous monitoring and regulation of glycemia. Children with type 1 diabetes face challenges that can disrupt their daily routines in school and kindergarten.
- Trial name
- PKA-T1D-EDU (NCT07148076)
- Testing
- Education Program
- Where
- 2 sites in Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sibenik University of Applied Sciences
Diabetes Mellitus, Type 1
Impact of Different Types of Exercise Training on Biochemical Markers of Insulin-dependent Patients
Background: Type 1 diabetes mellitus (T1DM) is characterized by the destruction of β cells and consequent loss of insulin secretion due an autoimmune process, being associated with increased cardiovascular risk, oxidative stress…
- Trial name
- NCT02939768
- Testing
- High-intensity interval training (HIIT), Strength training (ST), ST combined with HIIT (ST+HIIT)
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Rio Grande do Sul
Diabetes Mellitus, Type 1, Periodontal Diseases
Periodontal and Salivary Evaluation of Type 1 Diabetes Mellitus Patients
Diabetes Mellitus is a risk factor for periodontal disease increasing its prevalence, extension and severity. Periodontal disease is considered the sixth complication of diabetes.
- Trial name
- NCT02935868
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Volunteers, Type 1 Diabetes
Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients
First in human study to understand the potential side effects of MTX-101, how long MTX-101 lasts in the human body, and how MTX-101 affects specific human immune cells.
- Trial name
- NCT06324604
- Testing
- MTX-101
- Where
- 3 sites in Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mozart Therapeutics Australia Pty Ltd
Advanced Solid Tumor, Metastatic Cancer
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
This is a first in human, open-label, multi-center Phase 1 / 2 study to evaluate the safety, tolerability, and initial efficacy of AU-007, also known as imneskibart, in patients with advanced solid tumors.
- Conditions
- Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer
- Trial name
- NCT05267626
- Testing
- AU-007, Aldesleukin, Avelumab
- Where
- 17 sites in United States, Australia
- Volunteers
- 159 people
- Sponsor
- Aulos Bioscience, Inc.
Diabetes Mellitus, Type 1
Assess the Impact of Insulclock on Glycemic Variability and Treatment Compliance in Uncontrolled DM1 Patients
Insulclock® is a small electronic device developed to facilitate the optimal administration of insulin. This device works as an add-on module of commercially available insulin pens and monitors the date, time and dose of…
- Trial name
- Segoclock2 (NCT04847778)
- Testing
- Use of Insulclock system, both Insulclock device and Insulclock 360 app., Use of Insulclock system, both Insulclock device and Insulclock app on masked mode.
- Where
- 4 sites in Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital General de Segovia
Type 1 Diabetes Mellitus (T1DM), End-Stage Renal Disease
Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden
The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease.
- Trial name
- NCT06883318
- Where
- Sweden
- Volunteers
- 115,000 people
- Sponsor
- Umeå University
Diabetes Mellitus, Type 1
Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus
Insulin lispro is approved by the Food and Drug Administration (FDA) for the treatment of diabetes mellitus. Recombinant human hyaluronidase (rHuPH20) is approved by the FDA as an aid to the absorption and dispersion of other…
- Trial name
- NCT00883558
- Testing
- Insulin Lispro, regular human insulin, recombinant human hyaluronidase PH20
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Halozyme Therapeutics
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this clinical trial is to evaluate the variability in the blood glucose-lowering effect of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- NCT00961324
- Testing
- insulin degludec, insulin glargine
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Hypoglycemia
Cognitive Function and Electrocardiogram (ECG) During Hypoglycemia and Blockade of the Renin-angiotensin System
Hypothesis: Treating patients with type 1 diabetes with a certain antihypertensive drug preserve cerebral function during hypoglycaemia.
- Trial name
- NCT01116180
- Testing
- Angiotensin II receptor antagonists (Candesartan)
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Louise Faerch
Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion and VX-017 infusion in participants with type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
- Conditions
- Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
- Trial name
- NCT04786262
- Testing
- VX-880, VX-017
- Where
- 29 sites in United States, Canada and 8 more
- Volunteers
- 57 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Telemedicine Continuous Remote Monitoring of Adults With Uncontrolled Diabetes Mellitus
The purpose of this single center observational study is to determine the effect of continuous remote continuous glucose monitor (CGM) reporting coupled with a telemedicine intervention (Tele-CGM program) on levels of HbA1C in…
- Trial name
- TELEMTRRDM (NCT05161793)
- Testing
- Tele-Monitor DM
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- University of Southern California
Diabetes Type I, Diabetes Type II
Feasibility Study of DermGEN for Diabetic Foot Ulcer Treatment
The purpose of this clinical trial is to perform a limited pilot study to determine the safety and feasibility of DermGEN in the treatment of non-healing diabetic foot ulcers (DFU). This will be a one-arm prospective study.
- Trial name
- NCT02184455
- Testing
- DermGEN
- Where
- 2 sites in Canada
- Volunteers
- 11 people
- Sponsor
- Dr. Paul F. Gratzer
Diabetes, Diabetes Mellitus, Type 1
Paediatric Subjects - Special Survey
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using insulin aspart in children with diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01538576
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Hypoglycemia Fear Affect Autonomic Function, Physical Activity, and Exercise Capacity in Type I Diabetes
This cross-sectional study aims to investigate whether fear of hypoglycemia affects autonomic function, physical activity levels, and exercise capacity in children and adolescents with T1DM.
- Trial name
- HypoFear-T1DM (NCT07527676)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Ordu University
Diabetes Mellitus, Type 1
Steno Tech Explore: A Study of Insulin Pump Users With Type 1 Diabetes
The present study is part of an overarching study being conducted in Denmark at Steno Diabetes Center Copenhagen (SDCC) and Nordsjællands Hospital Hillerød (NOH), Steno Tech, that aims to develop and ultimately, in a randomized…
- Trial name
- NCT04311164
- Testing
- Questionnaire-based survey, No intervention given.
- Where
- 2 sites in Denmark
- Volunteers
- 770 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes
The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies
Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed…
- Trial name
- NCT06173934
- Testing
- insulin injection 15 minutes before meals, Insulin injection 15 minutes after eating
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
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