Clinical trials: Kava
Tobacco Smoking
Investigation of Kava Effects on NNK Metabolism
This is a non-therapeutic, single-arm pilot clinical trial in adult healthy smokers to assess whether kava can alter NNK metabolism in humans.
- Trial name
- NCT02500472
- Testing
- Kava
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pharmacokinetics
Biomarker Changes and Anxiolytic Effects-Phase 2
This study will examine the utility of plasma and urinary based biomarkers for the anxiolytic properties of kava. The investigators will conduct a one week, double blind, randomized placebo controlled trial of kava, dosed at…
- Trial name
- KavaPK (NCT04565145)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sleep
Kavalactones on Sleep and Cortisol in Healthy Special Forces Trainees
This research study is being done to better understand the effects of kava supplementation on sleep quality and salivary cortisol in the context of the acute physical and psychological stress of military special forces…
- Trial name
- NCT05381025
- Testing
- Kava (Piper methysticum) extract
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Thorne HealthTech, Inc
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Herb-Herb Interaction, Pharmacokinetics
Pharmacokinetics of Kava and Kratom Alone and in Combination
This study is being conducted to evaluate how different formulations of the Feel Free® Tonic containing Kava, Kratom, or a combination of both are processed in the body in healthy adults.
- Trial name
- NCT07583407
- Testing
- Kava and Kratom Herbal Supplement, Kava Herbal Supplement, Kratom Herbal Supplement
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Botanic Tonics, LLC
Pharmacokinetics
A Phased Clinical Trial of Dietary Supplemental Kava: Kava Pharmacokinetics
Kava is a dietary supplement on the US market and is experiencing a resurgence of its use. Its pharmacokinetic information, however, is lacking which is important for its future effective usage as a dietary supplement or…
- Trial name
- KavaPK (NCT03843502)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida