Clinical trials: Kawasaki Disease
Kawasaki Disease
Kawasaki Disease During the COVID-19 Epidemic
Northern Italy is the second region hit by the SARS-COV2 infection worldwide. Data on COVID-19 clinical presentation in children is still scarce, but fewer rate of infection and milder disease seem typical of this age group.
- Trial name
- KAWACOVID (NCT06309303)
- Testing
- Clinical evaluation
- Where
- 4 sites in Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Burlo Garofolo
COVID-19 Infection
Cardiac and Thoracic Imaging in Pediatric Patients With Evidence of Systemic Inflammation COVID19 Linked
To perform comprehensive cardiac and thoracic non invasive imaging assessment by MRI and/or CT scan including cardiac functional evaluation and myocardial tissue characterization of COVID_19 related disease in pediatric patients…
- Trial name
- CARDOVID (NCT04455347)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Imagine Institute
Kawasaki Disease
Defibrotide in Children With High Risk Kawasaki Disease
This study evaluates the safety of defibrotide with IVIG in children with high risk Kawasaki disease.
- Trial name
- NCT04777422
- Testing
- Defibrotide
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- New York Medical College
SARS CoV-2, Kawasaki Disease
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)
Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes. The significance of their presence in DNA is still being studied, but HERVs appear to be involved in…
- Conditions
- SARS CoV-2, Kawasaki Disease, Retrovirus Infection
- Trial name
- HERV_COVID (NCT06775457)
- Testing
- sample collection
- Where
- 5 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Primary Immunodeficiency Diseases (PID), Immune Thrombocytopenic Purpura (ITP)
Safety and Efficacy Study of a 10% Intravenous Immune Globulin Solution in Subjects With Primary Immunodeficiency Disorders
The purpose of this study is to assess the safety and efficacy of Immune Globulin Intravenous (Human), 10% (IGIV 10%) in subjects with primary immunodeficiency disorders.
- Conditions
- Primary Immunodeficiency Diseases (PID), Immune Thrombocytopenic Purpura (ITP), Kawasaki Syndrome
- Trial name
- NCT00157079
- Testing
- Immune Globulin Intravenous (Human), 10%
- Where
- 11 sites in United States
- Volunteers
- 61 people
- Sponsor
- Baxalta now part of Shire
Kawasaki Disease
The Value of Cardiovascular Imaging in Kawasaki Disease
The goal of this observational study is to assess the cardiovascular injury of Kawasaki disease with multi-modal imaging combined with clinical data.
- Trial name
- NCT06641817
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Kawasaki Disease
A Trial to Determine Radiation Exposure to Organs and Assess the Safety of CARDIOLITE® in Pediatric Subjects
The purpose of this Phase I-II multicenter clinical trial is to establish dosimetry and safety profiles for CARDIOLITE® (Technetium Tc99m Sestamibi) in pediatric subjects.
- Trial name
- NCT00162045
- Testing
- Technetium Tc99m Sestamibi
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 79 people
- Sponsor
- Lantheus Medical Imaging
Kawasaki Disease
Pharmacokinetics (PK)/Safety Study of Atorvastatin in Children With Kawasaki Disease and Coronary Artery Abnormalities
Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the developed world. Despite available treatment, 25% of children in San Diego County appropriately treated for KD develop coronary artery…
- Trial name
- NCT01431105
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Diego
Kawasaki Disease
Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease
The purpose of this study is to evaluate the safety, efficacy and of Immune Globulin Intravenous (Human) IVIG-SN™ in subjects with kawasaki diseases.
- Trial name
- NCT01524939
- Testing
- immunoglobulin G
- Where
- 7 sites in South Korea
- Volunteers
- 45 people
- Sponsor
- Green Cross Corporation
Cardiovascular Diseases, Heart Diseases
Trial of Pulse Steroid Therapy in Kawasaki Disease--Pediatric Heart Network
The primary endpoint is coronary artery diameter, normalized for body surface area, 5 weeks after randomization. Secondary endpoints include duration of fever, CRP levels, and adverse events.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Infection, Coronary Aneurysm
- Trial name
- NCT00132080
- Testing
- Steroids
- Volunteers
- 199 people
- Sponsor
- Carelon Research
Kawasaki Disease
Kawasaki MATCH Trial
Evaluating the impact of a machine-learning clinical decision support tool on provider practice when evaluating febrile patients with Kawasaki Disease (KD) and non-KD illnesses.
- Trial name
- MATCH (NCT07291245)
- Testing
- Kawasaki MATCH
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Kawasaki Disease, Chest X-ray for Clinical Evaluation
Clinical Study on an Artificial Intelligence-Assisted Chest Radiograph Model Based on Big Data and Deep Learning for Early Detection of Kawasaki Disease
The goal of this observational study is to develop an AI-based early warning system for Kawasaki Disease (KD) using chest X-rays (CXR) in children diagnosed with Kawasaki Disease. The main question[s] it aims to answer are: 1.
- Conditions
- Kawasaki Disease, Chest X-ray for Clinical Evaluation, Mucocutaneous Lymph Node Syndrome
- Trial name
- NCT07405658
- Testing
- AI-Based Early Warning System for Kawasaki Disease
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Kawasaki Disease, Coronary Aneurysm
Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Kawasaki disease (KD) affects infants and young children causing inflammation of the skin and blood vessels including the coronary arteries of the heart.
- Trial name
- NCT01917721
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hawaii Pacific Health
Cardiovascular Diseases, Coronary Aneurysm
Prevention of Coronary Aneurysms in Kawasaki Syndrome
To test the efficacy of intravenous gamma globulin (IVGG) in preventing coronary artery aneurysms in children with Kawasaki Syndrome.
- Conditions
- Cardiovascular Diseases, Coronary Aneurysm, Heart Diseases, Mucocutaneous Lymph Node Syndrome
- Trial name
- NCT00000520
- Testing
- immunoglobulins, intravenous, aspirin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kawasaki Disease, Inflammation
Characterization of Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Relationship to Kawasaki Disease
Beginning in mid-March 2020, pediatricians in communities in Western Europe, the UK, and the Eastern U.S. that had been severely affected by the Covid-19 pandemic noted an increased number of children presenting with fever and…
- Trial name
- NCT04538495
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of California, San Diego
Kawasaki Disease
Cardiovascular Risk Markers and Response to Statins After Kawasaki Disease
The purpose of this study is to determine whether Chilean children with history of Kawasaki disease have endothelial dysfunction years after the acute phase of the disease, and if this condition can be modified by treatment with…
- Trial name
- NCT00305201
- Testing
- pravastatin
- Where
- Chile
- Sponsor
- Pontificia Universidad Catolica de Chile
Mucocutaneous Lymph Node Syndrome
Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease
In this study, the investigator plan to prescribe Methylprednisolone pulse therapy in Kawasaki disease patients with coronary artery lesions or aneurysm formation beyond acute stage to investigate the role for vasculitis of KD or…
- Trial name
- NCT04509219
- Testing
- Methylprednisolone Injection
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Kawasaki Disease
A Blood Test to Diagnose Kawasaki Disease
A case-control cohort study is being conducted to develop and validate the performance of a whole blood gene expression qPCR test to distinguish KD from other febrile conditions by collecting whole blood sample from KD patients…
- Trial name
- NCT05091229
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Kawasaki Disease
Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012
To investigate the epidemiological pictures of Kawasaki disease (KD) in Shanghai from 2008 through 2012, and illustrate the risk factors of coronary arterial lesions .
- Trial name
- NCT02317913
- Where
- China
- Volunteers
- 2,402 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Kawasaki Disease
A Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment
Kawasaki disease (KD) is the most frequent vasculitis in younger children <5years, and the first cause of acquired ischemic myocardiopathy in childhood.
- Trial name
- ANACOMP (NCT04656184)
- Testing
- ANAKINRA, Intravenous immunoglobulin
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris