Clinical trials: Keloid Scars
Keloid, Keloid of Ear Lobe
Gene Expression and Biomarker Profiling of Keloid Skin
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's…
- Conditions
- Keloid, Keloid of Ear Lobe, Healthy Adults
- Trial name
- NCT03228693
- Testing
- Biopsy and/or triamcinolone injection, Excisional Biopsy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Skin Diseases, Keloid
Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III
The goal of this study is to establish the safety of high fluence LED-RL at fluence of 480 J/cm2 and 640 J/cm2 in healthy non-Hispanic, Caucasian subjects.
- Conditions
- Skin Diseases, Keloid, Scar, Fibrosis
- Trial name
- NCT03433222
- Testing
- HF-LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Northern California Health Care System
Keloid Scar Following Surgery
Initial Assessment of a Topical Cadexomer Iodine Gel Efficacy on Keloid Scar Revision
This is a 6 month, single site, interventional, open label prospective clinical study to evaluate the effects of a cadexomer iodine gel on the prevention of recurrent keloid formation in patients undergoing keloid scar revision.
- Trial name
- NCT03876548
- Testing
- Cadexomer Iodine Gel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Next Science TM
Keloids, Fibroblast
Keloid Pathogenesis And Fibroblast Activation Study
Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood.
- Trial name
- KPS (NCT07682636)
- Testing
- Tissue Collection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Fibrosis, Skin Scarring
Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Skin scarring (fibrosis) is a common complication in the wound healing process and remains a therapeutic challenge. Scar formation often occurs following injury to the skin such as surgery, trauma, and burns.
- Conditions
- Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar
- Trial name
- NCT03795116
- Testing
- LED-RL phototherapy, Mock irradiation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Scar Keloid
Botulinum Toxin Type a Injection to Prevent Keloid Recurrence
The prospective, split-scar, double-blind, randomized controlled study will enroll the patients who are older than 20 years with progressive keloid lesion which is symmetric.
- Trial name
- NCT05072821
- Testing
- Botulinum Toxin Type A Injection [Botox], 0.9% Sodium Chloride Injection
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Keloid
RAPA-Keloid Study of Keloid Regression
1. To test whether topical rapamycin regresses established keloids in humans by measuring surface area and height changes in the scar over time (6 months) 2.
- Trial name
- NCT04049552
- Testing
- Rapamycin 8% Ointment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Keloid, Hypertrophic Scar
A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars
Keloids are thought to result from derailments in the typical wound healing process following cutaneous injury. Current treatment options for keloids include intralesional corticosteroids, silicone gel sheeting, compression…
- Conditions
- Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic
- Trial name
- NCT00754247
- Testing
- 0.5% hydrocortisone, silicone, vitamin E lotion, Onion extract gel, Cetearyl alcohol lotion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Skin Diseases, Hypertrophic Scar
Piezoelectric Drived Microneedling in Treating Refractory Skin Diseases
Piezoelectric drived microneedling treats refractory skin disorders using hollow microneedles assisted by ultrasound. Mechanically, the injection of medicine by hollow microneedling could makes the distribution of medicine more…
- Conditions
- Skin Diseases, Hypertrophic Scar, Keloid, Plantar Wart
- Trial name
- NCT05488860
- Testing
- Triamcinolone acetonide(scar)/5-ALA(others), Piezoelectric drived microneedling, 5-ALA (a photosensitizer for photodynamic therapy).
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Blisters, Second Degree Burns
Evaluation and Comparison of Keloids and Second Degree Burns Blisters Fluid
It is well documented that following thermal burns injury the development of hypertrophic scars and keloid (HSK) ranges between 40 to 90%.
- Conditions
- Blisters, Second Degree Burns, Wounds
- Trial name
- NCT01627769
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Cicatrix, Cicatrix, Hypertrophic
FS2 Safety and Tolerability Study in Healthy Volunteers
Background Scarring typically occurs after trauma, burn injury or surgery. Hypertrophic scarring presents as raised, red and itchy lesions which variably respond to various treatment modalities, such as corticosteroids, pressure…
- Conditions
- Cicatrix, Cicatrix, Hypertrophic, Keloid
- Trial name
- NCT02340325
- Testing
- Acute Application of kynurenic acid cream, Chronic application of kynurenic acid cream
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- British Columbia Professional Firefighters' Burn and Wound Healing Laboratory
Keloid
The Safety and Efficacy of Thermo-mechanical System for Fractional Ablation Associated Triamcinolone Acetonide Drug Delivery for the Treatment of Hypertrophic Scars and Keloids
This study aims to assess the safety and efficacy of Thermo-mechanical system for fractional ablation associated triamcinolone acetonide drug delivery for the treatment of Hypertrophic scars and Keloids.
- Trial name
- NCT04597060
- Testing
- Thermomechanical system with corticosteroids, corticosteroid injection
- Where
- Thailand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Skin, Scar
Therapy of Scars and Cutis Laxa With Autologous Adipose Derived Mesenchymal Stem Cells
The aim of this study is to compare clinical outcomes of patients with large scars or Cutis laxa treated with injections of autologous stromal vascular fraction cells (SVF) and adipose-derived mesenchymal stem cells (ADSC).
- Conditions
- Skin, Scar, Cutis Laxa, Keloid
- Trial name
- 2ABC (NCT03887208)
- Testing
- Laser therapy, Autologous ADSC injection, Normal saline injection
- Where
- 3 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Keloid, Keloid Scar Following Surgery
Post-Surgical Injection With Triamcinolone Versus Triamcinolone/Fluorouracil in Treatment of Keloids
There have been many modalities utilized in the treatment of keloids of the head and neck, however none have been universally successful.
- Trial name
- NCT04710719
- Testing
- Triamcinolone Injection, Triamcinolone Injection and 5-fluorouracil injection
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Caesarean Wound, Hypertrophic Surgical Scar
: Protescal: Prevention of Hypertrophic Scar and Keloid Formation Post Caesarean Section
This study aimed to evaluate the effectiveness of Protescal in preventing post caesarean section hypertrophic scar and keloid formation.
- Conditions
- Caesarean Wound, Hypertrophic Surgical Scar, Keloid Scar Following Surgery
- Trial name
- NCT04951869
- Testing
- Protescal gel
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Keloid, Wound Heal
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches.
- Conditions
- Keloid, Wound Heal, Wound
- Trial name
- NCT06138964
- Testing
- siSPARC + siLR4A microneedle patches, siSPARC microneedle patch
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Skin Centre