Clinical trials: Keratoconjunctivitis Sicca
Dry Eye Syndromes
Treatment of Dry Eye With Supplements
Dry eye syndrome (DES) is a highly prevalent ocular condition inducing an inflammatory response on the ocular surface. Common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential…
- Trial name
- NCT01364311
- Testing
- Vitamac® Tag and Nacht capsules
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye Syndrome
A Study to Assess Symptom Relief and Product Tolerability of ABBV-444 Drops in Adult Participants
Dry Eye Disease (DED) is a condition where the tear film of the eye becomes unstable and along with ocular surface inflammation and damage leads to inadequate tear production and eye lubrication.
- Trial name
- NCT05878067
- Testing
- ABBV-444
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AbbVie
Dry Eye
A 2-week Clinical Comparison of SYSTANE® Ultra to Sensitive Eyes Rewetting Drops in Contact Lens Wearing Patients.
To evaluate safety with the use of Systane Ultra in contact lens wearers. A comparison to a currently marketed contact lens rewetting drop will be included as a control.
- Trial name
- NCT00769665
- Testing
- Systane Ultra, Sensitive Eyes Rewetting Drops
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Sjogren's Syndrome, Non-celiac Gluten Sensitivity
Wheat-free Diet in the Treatment of Sjogren's Syndrome
Recent data show that some foods can increase intestinal mucosa permeability and immune activation of subjects with gastrointestinal (GI) symptoms.
- Trial name
- NCT05644795
- Testing
- Wheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Dry Eye Syndromes
Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes
The purpose of this clinical Study is TJCS Eye Drops 0.05%(Cyclosporine ophthalmic nano-emulsion) group and Restasis Eye Drops 0.05%(Cyclosporine ophthalmic suspension) group 12 weeks after treatment, each treatment group…
- Trial name
- NCT02461719
- Testing
- CYPORIN N EYE DROPS 0.05%(TJCS eye drop), Restasis
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Dry Eye
A Phase 1/2, RU-101 Ophthalmic Solution in Patients With Severe Dry Eye
Objectives: Primary To determine the safety and tolerability of escalating doses of RU-101 for 4 weeks in patients with severe dry eye Secondary To explore the efficacy of RU-101 To explore optimal endpoints for future studies
- Trial name
- NCT01843894
- Testing
- RU-101
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- R-Tech Ueno, Ltd.
Sjogren's Syndrome, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
- Trial name
- NCT05085431
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Sjogren Syndrome With Keratoconjunctivitis
Evaluating a New Therapy for Dry Eye in Patients With Sjögren's Syndrome
This study will evaluate the effect of TRYPTYR in patients with Sjögren's syndrome-related dry eye disease. The goal is to determine whether TRYPTYR can improve symptoms and signs of dry eye in this specific patient population.
- Trial name
- NCT07277257
- Testing
- TRYPTYR (Acoltremon ophthalmic solution 0.003%)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Center For Sight
Dry Eye Syndromes
Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients
This study is planned to Evaluate the Efficacy and Safety of test drug (AJU-S56) compared to control drug(vehicle) in Patients with Dry Eye Disease.
- Trial name
- NCT06337981
- Testing
- AJU-S56 5%
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- AJU Pharm Co., Ltd.
Sjogren's Syndrome
Interstitial Lung Diseases in Primary Sjogren's Syndrome
Patients with pSS seen in the Division of Rheumatology, the second affiliated hospital of Zhejiang University, School of Medicine (SAHZU) during January 2016 to July 2018, were retrospectively reviewed.
- Trial name
- NCT04978883
- Testing
- No intervention
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ocular Graft-versus-host Disease
Evaluation of Safety & Efficacy for the Prevention of Ocular GVHD With Ophthalmic Tacrolimus vs Cyclosporine in Allo-HSCT
Chronic GVHD (cGVHD) is a predominant cause of mortality and disability not related to relapse; it occurs in 30 to 70% of patients.
- Trial name
- NCT06348602
- Testing
- Cyclosporine ophthalmic solution 0.1%, Tacrolimus ophthalmic ointment 0.03%
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hemodialysis, Ocular Surface Disease
Evaluation of Ocular Surface in Hemodialysis Patients by Ocular Surface Analyzer
We clinically observed that some hemodialysis patients had corneal epithelial dryness, shedding, edema, and persistent epithelial nonunion after ocular surgery, which seriously affected the effect of surgery, and it is necessary…
- Conditions
- Hemodialysis, Ocular Surface Disease, Dry Eye, OSDI
- Trial name
- NCT04949295
- Testing
- ocular surface analyzer
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- XiaoYong Liu
Dry Eye Syndromes, Diabetic Retinopathy
Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy
The main objective of our study is to evaluate the effect of eye drops with antioxidants on mild to moderate dry eye symptoms in patients with diabetic retinopathy, evaluating the levels of inflammatory cytokines and oxidative…
- Conditions
- Dry Eye Syndromes, Diabetic Retinopathy, Oxidative Stress, Tear Film Deficiency
- Trial name
- NCT05429229
- Testing
- VisuXL®, Lagricel PF®, Humylub PF®
- Where
- Mexico
- Volunteers
- 78 people
- Sponsor
- Adolfo Daniel Rodriguez-Carrizalez
Dry Eye
A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial of Reproxalap to Assess the Safety and Efficacy in Subjects With Dry Eye Disease
A Multi-Center, Phase 2, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution (0.25% Novel Formulation) Compared to Vehicle in Subjects…
- Trial name
- NCT03916042
- Testing
- Reproxalap Ophthalmic Solution (0.25% Novel Formulation) QID to BID, Vehicle Ophthalmic Solution (0.25% Novel Formulation) QID to BID
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Meibomian Gland Dysfunction, Dry Eye Syndromes
to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction
A Randomized, Masked (Evaluator), Controlled, Prospective Study Evaluating the Effectiveness and Safety of the Tixel® Medical Device, Versus LipiFlow® in the Treatment of Meibomian Gland Dysfunction
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Dry Eye
- Trial name
- NCT05162261
- Testing
- Tixel C, LipiFlow
- Where
- 5 sites in United States
- Volunteers
- 109 people
- Sponsor
- Novoxel Ltd.
Dry Eye
Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease
Investigate the Safety and Efficacy of Two Concentrations of DE-110 Compared to Placebo for the Treatment of Dry Eye Disease
- Trial name
- NCT01239069
- Testing
- DE-110 ophthalmic suspension high dose, DE-110 ophthalmic suspension low dose
- Where
- 14 sites in United States
- Volunteers
- 140 people
- Sponsor
- Santen Inc.
Dry Eye Disease (DED)
The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function
The purpose of this research study is to evaluate the effects of trehalose, an ingredient found in commercially available artificial tears, on the corneal barrier function.
- Trial name
- NCT06655441
- Testing
- 3% trehalose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Keratoconjunctivitis Sicca
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain…
- Trial name
- NCT00411827
- Testing
- PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Dry Eye
Phase II Clinical Study to Evaluate the Efficacy of Multidose Lagricel® Ofteno Ophthalmic Solution as Treatment for Dry Eye Disease.
Phase II, comparative, controlled, multicenter, parallel group, open, randomized clinical study. The main outcome variable will be the Ocular Surface Disease Index (OSDI) questionnaire.
- Trial name
- PRO-037 (NCT04704531)
- Testing
- Sodium Hyaluronate Ophthalmic 0.4% one drop twice a day (BID), Sodium Hyaluronate Ophthalmic 0.4% one drop four times a day (QID), Sodium Hyaluronate Ophthalmic 0.4% Six times per day
- Where
- Mexico
- Volunteers
- 141 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Sjogren's Syndrome
tDCS for Fatigue in Sjogren's Syndrome
Sjogren's Syndrome (SS) is an autoimune disease of unknown etiology characterized by lymphocytic infiltration of the exocrine glands and other organs.
- Trial name
- NCT04119128
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Federal University of São Paulo