Clinical trials: Keratopathy
Corneal Edema, Fuchs
Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells [mHCECs]), compared with a placebo injection, in…
- Conditions
- Corneal Edema, Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- EMERALD (NCT07729137)
- Testing
- 150K cells, 500K cells
- Where
- 10 sites in United States
- Volunteers
- 121 people
- Sponsor
- Emmecell
Bullous Keratopathy
Utilization of Residual Donor Tissue for Regrafting in Bullous Keratopathy After Corneal Transplantation
Postoperative endothelial cell loss following Descemet stripping endothelial keratoplasty (DSEK) remains a well-recognized clinical concern, with long-term follow-up demonstrating approximately 50% reduction in endothelial cell…
- Trial name
- NCT07855601
- Testing
- Endothelial keratoplasty using residual donor tissue
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Edema, Corneal Endothelial Dysfunction
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK)
- Trial name
- NCT07368959
- Testing
- Combination Product: AURN001 + Y-27632
- Where
- 12 sites in United States
- Volunteers
- 130 people
- Sponsor
- Aurion Biotech
Corneal Edema, Corneal Endothelial Disorder
The Belgian Endothelial Surgical Transplant of the Cornea
This study is designed as a randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial…
- Conditions
- Corneal Edema, Corneal Endothelial Disorder, Fuchs' Endothelial Dystrophy, Bullous Keratopathy
- Trial name
- BESTCornea (NCT05436665)
- Testing
- UT-DSAEK, DMEK
- Where
- 11 sites in Belgium
- Volunteers
- 220 people
- Sponsor
- University Hospital, Antwerp
Pseudophakic Bullous Keratopathy, Glaucoma
The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)
The goal of this clinical trial is to learn if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy in patients with glaucoma.
- Trial name
- NCT06960629
- Testing
- Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Ocular Surface Disease, Neurotrophic Keratopathy Stage 1
Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neurotrophic Keratopathy Patients With Tear Deficiency
STUDY OBJECTIVE To assess if acoltremon 0.003% improves tear production in patients with Stage 1 Neurotrophic Keratopathy.
- Trial name
- NCT07502378
- Testing
- Patients will receive topical Acoltremon 0.003% ophthalmic solution BID in both eyes over an 8 week period., Alternative would be patient exiting the trial and starting on tears or other standard of care.
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Bullous Keratopathy, Corneal Endothelial Dystrophy
Simple Non-cultured Endothelial Cell Therapy for Corneal Endothelial Dysfunction
Assessment of safety and efficacy of cell injection therapy generated using non-cultured human corneal endothelial cells in treating corneal endothelial dysfunction
- Trial name
- NCT07711561
- Testing
- Cell injection
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Singapore Eye Research Institute
Neurotrophic Keratopathy, Exposure Keratopathy
Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases
This retrospective-prospective study aims to identify the diagnostic parameters most predictive of BSCVA in patients with OSD. Clinical, structural, and biochemical data will be collected from standard-of-care examinations and…
- Conditions
- Neurotrophic Keratopathy, Exposure Keratopathy, Limbal Stem Cell Deficiency (LSCD), Cornea Abnormality
- Trial name
- OSD (NCT07694817)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Bullous Pseudophakic Keratopathy, Penetrating Keratoplasty
Effectiveness of PKP vs DSAEK in Terms of 2-year Postoperative Visual Acuity in Advanced BPK
This is an open-label multicenter randomised controlled clinical trial with 2 parallel arms with a 1:1 ratio. Patients meeting the eligibility criteria will be offered to participate in the study during an ophthalmology…
- Trial name
- DESPEK (NCT06818747)
- Testing
- Best corrected monocular visual acuity
- Where
- 11 sites in France
- Volunteers
- 334 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Artifical Intelligence, Cataract
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
This is a multi-center, cross-sectional study evaluating a smartphone-based artificial intelligence (AI) system for anterior segment eye disease screening.
- Conditions
- Artifical Intelligence, Cataract, Pterygium, Keratopathy
- Trial name
- LENS (NCT07634913)
- Testing
- Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Injury, Exposure Keratopathy
Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection
During general anesthesia, the eye's natural protective reflexes are suppressed, which can lead to corneal drying and injury. To prevent this, anesthesiologists routinely tape the eyelids closed.
- Conditions
- Corneal Injury, Exposure Keratopathy, Perioperative Complications
- Trial name
- NCT07562594
- Testing
- Hypoallergenic Eyelid Taping, Hypoallergenic Eyelid Taping With Lubricant Eye Drops
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Neurotrophic Keratopathy
Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy
Neurotrophic keratopathy (NK) is a condition where the cornea loses its capacity to feel pain and touch. This causes a decrease in the production of certain substances that maintain the integrity of the corneal epithelium (the…
- Trial name
- NCT04604834
- Testing
- PFAT first, APRP first
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Diabetic Keratopathy
Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases
The purpose of this study is to determine whether poly（β-amino ester）(PAE)hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes(tRF-ASO-Exo) could alleviate symptoms in patients with diabetic ocular…
- Trial name
- NCT07382453
- Testing
- Exosomes, tRNA-derived fragments-antisense oligonucleotides-exosomes, poly（β-amino ester）hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
Corneal Edema, Fuchs' Endothelial Dystrophy
PVEK Corneal Implant For Treatment of Corneal Edema
The goal of this clinical trial is to learn if PVEK, a corneal implant , is safe and well tolerated for people with corneal swelling caused by Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy who need endothelial…
- Conditions
- Corneal Edema, Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Corneal Endothelial Dysfunction
- Trial name
- CIFRE (NCT07325097)
- Testing
- Precise Vision Endothelial Keratoplasty (PVEK) Implant
- Where
- 3 sites in Armenia, Israel
- Volunteers
- 15 people
- Sponsor
- Precise Bio
Neurotrophic Keratopathy
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)
- Trial name
- NCT05555589
- Testing
- RGN-259
- Where
- 36 sites in United States, Italy and 2 more
- Volunteers
- 70 people
- Sponsor
- ReGenTree, LLC
Corneal Edema, Corneal Endothelial Dystrophy
Study to Assess Safety and Tolerability of Multiple Doses of EO2002
The goal of this clinical study is to assess the safety of multiple intracameral injections of EO2002 with and without topical Ripasudil.
- Conditions
- Corneal Edema, Corneal Endothelial Dystrophy, Endothelial Dysfunction, Fuchs Dystrophy
- Trial name
- NCT05636579
- Testing
- EO2002, Ripasudil
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy
The OPTIMISE Study
Rationale: The cornea is the most transplanted tissue in the Netherlands, with more than 1,500 procedures performed each year. A minimally invasive technique called Descemet Membrane Endothelial Keratoplasty (DMEK) has become the…
- Conditions
- Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure
- Trial name
- NCT05716945
- Testing
- Fluorometholone 0.1% Oph Susp, Dexamethasone 0.1% ophthalmic suspension, Stop steroids
- Where
- 8 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Maastricht University Medical Center
Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy
Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty
Assessment of safety and efficacy of tissue-engineered corneal endothelial graft material generated using cultured human corneal endothelial cells for tissue-engineered endothelial keratoplasty (TE-EK).
- Conditions
- Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Post-surgical Corneal Decompensation (Irreversible)
- Trial name
- TE-EK (NCT04319848)
- Testing
- TE-EK treatment group
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore Eye Research Institute
Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
OCT in Fuchs' Dystrophy
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
- Trial name
- NCT04258787
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University