Clinical trials: Keratoplasty, Lamellar
Keratoconus
Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas
The objective of this study is to assess the outcomes between deep anterior lamellar keratoplasty using dehydrated versus standard organ culture stored donor corneas.
- Trial name
- NCT04430244
- Testing
- Deep anterior lamellar keratoplasty
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Internazionale di Ricerca e Formazione in Oftalmologia
Keratoconus
Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients
This study will be performed on patients who come to labbafinejad ophthalmic clinic from 20 March 2008. Keratoconus diagnosis will be determined by clinical finding in slit lamp, keratometery and topographic characteristics.
- Trial name
- NCT00850148
- Testing
- Anwar, Melles
- Where
- 2 sites in Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconus
Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)
Different techniques of deep anterior lamellar keratoplasty (DALK) have been introduced to create a uniform recipient bed, thereby reducing complications, such as interface irregularity and opacification encountered with…
- Trial name
- NCT02485951
- Testing
- Central air injection, Peripheral air injection
- Where
- Iran
- Volunteers
- 49 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Fuchs' Endothelial Corneal Dystrophy
Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology
Background Fuchs' Endothelial Dystrophy Fuchs' Endothelial Dystrophy (Fuchs' ED) is characterized by changes on the inside of the cornea, which leads to a substantial decline in visual acuity.
- Trial name
- NCT01979250
- Testing
- DSAEK surgery
- Where
- Denmark
- Volunteers
- 81 people
- Sponsor
- Aarhus University Hospital
Corneal Opacity, Keratoconus
OCT-guided LALAK for KCN
The purpose of this study is to determine if a new procedure, called laser-assisted lamellar anterior keratoplasty (LALAK), can achieve the same level of vision with a lower risk of potential complications after surgery compared…
- Trial name
- NCT01901614
- Testing
- LALAK, IEK, Retrobulbar Block or General Anesthesia
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Corneal Changes of Membranes
Preoperative Corneal Thickness and Postoperative Visual Outcomes After Posterior Lamellar Corneal Transplant
To evaluate the impact of preoperative corneal thickness on visual outcomes following Descemet's stripping endothelial keratoplasty (DSAEK) or Descemet membrane endothelial keratoplasty (DMEK)
- Trial name
- TransCor (NCT03355911)
- Volunteers
- 113 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal Transplantation
Deep Lamellar Endothelial Keratoplasty: Small Incision Technique
The research objectives of this study are to determine if small incision Deep Lamellar Endothelial Keratoplasty (DLEK) is able to further reduce the degree of corneal astigmatism and shorten the time course of corneal topography…
- Trial name
- NCT00345020
- Testing
- Deep Lamellar Endothelial Keratoplasty: Small Incision Technique
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ocular Burns
Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns
The purpose of this pilot study is to explore whether corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface…
- Trial name
- NCT03421769
- Testing
- EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yingfeng Zheng
DALK Corneal Transplant, Keratoconus
Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)
A prospective comparison between standard deep anterior lamellar keratoplasty (S-DALK) performed manually using a blade (trephine) and femtosecond laser-enabled deep anterior lamellar keratoplasty (IE DALK), where incisions are…
- Conditions
- DALK Corneal Transplant, Keratoconus, Scar
- Trial name
- NCT03732599
- Testing
- Standard Deep Anterior Keratoplasty (S-DALK), IE-DALK (femtosecond)
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Keratoconus, Corneal Opacity
Femtosecond Laser-assisted Anterior Lamellar Keratoplasty
The purpose of the study is evaluating safety and clinical efficiency of full femtosecond laser-assisted anterior lamellar keratoplasty (FS-ALK) for curing patients with keratoconus and corneal opacities
- Trial name
- NCT02301598
- Testing
- FS-ALK (Femtolaser-assisted anterior lamellar keratoplasty)
- Volunteers
- 13 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Keratoconus, Cornea
Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
Investigators' research is concerned observing the post-operative anterior segment OCT changes throughout the post- operative follow up of the patient and relating to improve the visual outcome of the surgery which is the goal of…
- Conditions
- Keratoconus, Cornea, Corneal Opacity
- Trial name
- NCT05345652
- Testing
- deep anterior lamellar keratoplasty
- Volunteers
- 20 people
- Sponsor
- Assiut University
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs Dystrophy, Corneal Edema
A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema
The objectives of this study are to compare the visual and refractive outcomes of deep lamellar endothelial keratoplasty (DLEK) with penetrating keratoplasty as treatment for certain cases of corneal edema due to endothelial…
- Trial name
- NCT00346138
- Testing
- Corneal transplantation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Keratoplasty, Grafting, Corneal
Descemet Endothelial Thickness Comparison Trial
The purpose of this study is to compare visual acuity outcomes of two types of endothelial keratoplasty: 1) Ultrathin Descemet's Stripping Endothelial Keratoplasty (DSAEK) or 2) Descemet's Membrane Endothelial Keratoplasty…
- Conditions
- Keratoplasty, Grafting, Corneal, Transplantation, Corneal, Transplantation, Cornea
- Trial name
- DETECT (NCT02373137)
- Testing
- DSAEK, DMEK, Endoserter
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Oregon Health and Science University
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Keratoconus
Deep Anterior Lamellar Keratoplasty (DALK)
The purpose of this study is to report outcomes of deep anterior lamellar keratoplasty (DALK) using the big-bubble technique.
- Trial name
- DALK (NCT00887900)
- Testing
- Deep anterior lamellar keratoplasty (DALK), Penetrated keratoplasty
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital Oftalmologico de Brasilia
Glycerin Cryopreserved Acellular Corneal Tissue, Deep Anterior Lamellar Keratoplasty
Deep Anterior Lamellar Keratoplasty (DALK) Using Acellular Corneal Tissue Promotes Corneal Allograft Survival in High Risk Patients
The purpose of this study is to study whether deep anterior lamellar keratoplasty (DALK) using acellular tissue will promote corneal graft survival in high risk patients.
- Conditions
- Glycerin Cryopreserved Acellular Corneal Tissue, Deep Anterior Lamellar Keratoplasty, High Risk Keratoplasty
- Trial name
- NCT01021046
- Testing
- DALK using GCCT, DALK using FCT
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Wenzhou Medical University
Fuch's Endothelial Dystrophy
Comparison of Two Techniques in Achieving Corneal Graft
The cornea is a transparent membrane, half a millimeter thick, embedded as a window in front of the eye. When the eye becomes opaque, the eye is not seeing and the only way to restore the visual acuity is to replace the cornea by…
- Trial name
- NCT01610973
- Testing
- Endothelial descemet membrane graft
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Fuchs Dystrophy, Endothelial Corneal Dystrophy
The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation
Rationale: Intra-operative optical coherence tomography (iOCT) is a new technology that incorporates advanced imaging techniques in the ophthalmic operating theatre.
- Conditions
- Fuchs Dystrophy, Endothelial Corneal Dystrophy, Bullous Keratopathy, Vision Disorders
- Trial name
- ADVISE (NCT03763721)
- Testing
- intraoperative optical coherence tomography (iOCT)
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 65 people
- Sponsor
- UMC Utrecht