Clinical trials: Keratoplasty, Lamellar
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Keratoconus
Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)
Different techniques of deep anterior lamellar keratoplasty (DALK) have been introduced to create a uniform recipient bed, thereby reducing complications, such as interface irregularity and opacification encountered with…
- Trial name
- NCT02485951
- Testing
- Central air injection, Peripheral air injection
- Where
- Iran
- Volunteers
- 49 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconus, Corneal Opacity
Femtosecond Laser-assisted Anterior Lamellar Keratoplasty
The purpose of the study is evaluating safety and clinical efficiency of full femtosecond laser-assisted anterior lamellar keratoplasty (FS-ALK) for curing patients with keratoconus and corneal opacities
- Trial name
- NCT02301598
- Testing
- FS-ALK (Femtolaser-assisted anterior lamellar keratoplasty)
- Volunteers
- 13 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
High-risk Corneal Transplantation, Corneal Blindess
Open-label Prospective Clinical Trial Evaluating the Safety and Efficacy of Biosynthetic CLP-PEG-MPC Corneal Implants in Patients Undergoing High-risk Deep Anterior Lamellar Keratoplasty.
This is an open-label and prospective clinical trial, in which a maximum of 5 eyes of 5 patients will receive a CLP-PEG-MPC synthetic cornea during deep anterior lamellar keratoplasty (DALK) surgery and will be followed up over…
- Conditions
- High-risk Corneal Transplantation, Corneal Blindess, Corneal Inflammation, Deep Anterior Lamellar Keratoplasty
- Trial name
- CLP-PEG-MPC (NCT05667337)
- Testing
- CLP-PEG-MPC, Human donor cornea penetrating keratoplasty
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal Opacity, Keratoconus
OCT-guided LALAK for KCN
The purpose of this study is to determine if a new procedure, called laser-assisted lamellar anterior keratoplasty (LALAK), can achieve the same level of vision with a lower risk of potential complications after surgery compared…
- Trial name
- NCT01901614
- Testing
- LALAK, IEK, Retrobulbar Block or General Anesthesia
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Fuchs' Endothelial Corneal Dystrophy
Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology
Background Fuchs' Endothelial Dystrophy Fuchs' Endothelial Dystrophy (Fuchs' ED) is characterized by changes on the inside of the cornea, which leads to a substantial decline in visual acuity.
- Trial name
- NCT01979250
- Testing
- DSAEK surgery
- Where
- Denmark
- Volunteers
- 81 people
- Sponsor
- Aarhus University Hospital
Keratoconus
Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients
This study will be performed on patients who come to labbafinejad ophthalmic clinic from 20 March 2008. Keratoconus diagnosis will be determined by clinical finding in slit lamp, keratometery and topographic characteristics.
- Trial name
- NCT00850148
- Testing
- Anwar, Melles
- Where
- 2 sites in Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Corneal Astigmatism in Cataract Patients and Previous DALK
Effectiveness of Toric Intraocular Lenses for Treating Corneal Astigmatism in Patients With Cataract and Previous DALK
the purpose of this study was to assess the efficacy of custom made toric intraocular lens implantation in patients with simultaneous post-DALK high corneal astigmatism and cataract.
- Trial name
- NCT03398109
- Testing
- Customized toric IOL for post-DALK atigmatism
- Volunteers
- 10 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Ocular Burns
Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns
The purpose of this pilot study is to explore whether corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface…
- Trial name
- NCT03421769
- Testing
- EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yingfeng Zheng
Keratoconus
A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
This randomized clinical trial will assess corneal astigmatism and visual outcomes in participants who have undergone corneal transplantation for keratoconus with ex vivo cross-linked donor corneal tissue versus participants who…
- Trial name
- EVOKE (NCT04584125)
- Testing
- Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Joseph B. Ciolino, MD
Corneal Endothelial Cell Loss, Fuchs' Endothelial Dystrophy
Technique And Results In Endothelial Keratoplasty
To assess and compare the complications and results of different lamellar endothelial keratoplasty techniques and its variations.
- Trial name
- TREK (NCT02470793)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty, Descemet Membrane Endothelial Keratoplasty
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- EDUARD PEDEMONTE-SARRIAS
Unrecognized Condition
Incidence and Management of Ocular Hypertension Following Deep Anterior Lamellar Keratoplasty
This is a retrospective case series study that included patients who performed deep anterior lamellar keratoplasty and presented with elevated intraocular pressure during follow up.
- Trial name
- Dalk (NCT04931316)
- Testing
- antiglaucoma
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Mansoura University
DALK Corneal Transplant, Keratoconus
Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)
A prospective comparison between standard deep anterior lamellar keratoplasty (S-DALK) performed manually using a blade (trephine) and femtosecond laser-enabled deep anterior lamellar keratoplasty (IE DALK), where incisions are…
- Conditions
- DALK Corneal Transplant, Keratoconus, Scar
- Trial name
- NCT03732599
- Testing
- Standard Deep Anterior Keratoplasty (S-DALK), IE-DALK (femtosecond)
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Leukoma
Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty
In this study safety and effectiveness of bioengineered cornea comprising of interpenetrating networks of recombinant human type III collagen and synthetic phospholipid - phosphorylcholine - will be tested in patients with…
- Trial name
- NCT02424006
- Testing
- RHCIII-MPC cornea, Donor cornea
- Where
- India
- Volunteers
- 2 people
- Sponsor
- L.V. Prasad Eye Institute