Clinical trials: Keratoplasty
Corneal Dystrophy
Microsurgical Robot-assisted Corneal Transplant
Full-thickness corneal grafting (transfixing keratoplasty) is a tissue graft described at the beginning of the 20th century, which has remained technically unchanged for several decades.
- Trial name
- GRACE (NCT06844123)
- Testing
- Robot-assisted keratoplasty
- Where
- France
- Volunteers
- 10 people
- Sponsor
- CHU de Reims
Keratoconus, Corneal Opacity
Femtosecond Laser-assisted Anterior Lamellar Keratoplasty
The purpose of the study is evaluating safety and clinical efficiency of full femtosecond laser-assisted anterior lamellar keratoplasty (FS-ALK) for curing patients with keratoconus and corneal opacities
- Trial name
- NCT02301598
- Testing
- FS-ALK (Femtolaser-assisted anterior lamellar keratoplasty)
- Volunteers
- 13 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Keratopathy
Immunosuppression After Repeat Keratoplasty
Purpose: To compare the efficacy of topical 0.03% tacrolimus with systemic mycophenolate mofetil (MMF) in preventing corneal allograft rejection after repeat keratoplasty.
- Trial name
- NCT04147390
- Testing
- prescribe topical 0.03 % tacrolimus, prescribe mycophenolate mofetil(MMF)
- Where
- Iran
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Corneal Edema, Fuchs' Endothelial Dystrophy
PVEK Corneal Implant For Treatment of Corneal Edema
The goal of this clinical trial is to learn if PVEK, a corneal implant , is safe and well tolerated for people with corneal swelling caused by Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy who need endothelial…
- Conditions
- Corneal Edema, Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Corneal Endothelial Dysfunction
- Trial name
- CIFRE (NCT07325097)
- Testing
- Precise Vision Endothelial Keratoplasty (PVEK) Implant
- Where
- 3 sites in Armenia, Israel
- Volunteers
- 15 people
- Sponsor
- Precise Bio
Corneal Disease
Evaluation of Biosynthetic Constructs to Replace Donor Corneas
Constructs made from cross-linked Human Recombinant Collagen type III are being used instead of human donor corneas in 6 patients at Deep anterior lamellar cornea grafting.
- Trial name
- NCT02374723
- Testing
- NuCornea, donated human corneas
- Sponsor
- Region Östergötland
Dry Eye Disease
Study of Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Who Are Scheduled for Laser Epithelial Keratomileusis (LASEK) Surgery
This study aims to evaluate the efficacy and safety of applying pulse Electrical Stimulation around eye after laser keratoplasty (LASEK) in patients with dry eye syndrome.
- Trial name
- NCT06120348
- Testing
- Charge-Balanced, Symmetric Nerve Stimulation
- Where
- 6 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Nu Eyne Co., Ltd.
Corneal Edema, Fuchs Dystrophy
Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema
Single center, phase 1 study to evaluate the safety and tolerability of EO1404 in subjects with corneal edema secondary to pseudophakic bullous keratopathy or Fuch's endothelial dystrophy.
- Conditions
- Corneal Edema, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
- Trial name
- NCT04191629
- Testing
- EO1404, Endothelial brushing or Descemet stripping
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Valeria Sanchez-Huerta
Fuchs' Endothelial Dystrophy
DMEK Versus DSAEK Study
The purpose of this study is to determine whether corneal transplantation by Descemet Membrane Endothelial Keratoplasty more favourable and cost-effective is compared to Descemet Stripping Automated Endothelial Keratoplasty for…
- Trial name
- DMEK (NCT02793310)
- Testing
- DMEK, DSAEK
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Maastricht University Medical Center
Corneal Blindness
A Clinical Study to Evaluate the KeraKlear Keratoprosthesis in Patients With Corneal Opacity
To evaluate the safety and probable benefit of the KeraKlear Non-Penetrating Keratoprosthesis when implanted in an eye with corneal opacity that is at high risk of complications with PK.
- Trial name
- NCT03126903
- Testing
- KeraKlear Non-Penetrating Keratoprosthesis
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- KeraMed, Inc.
Fuchs' Endothelial Dystrophy
Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT
Fuchs endothelial corneal dystrophy (FECD) is a progressive disease characterized by the loss of endothelial cells, thickening of Descemet's membrane and deposition of extracellular matrix in the form of guttae.
- Trial name
- NCT02542644
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- 2 sites in Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Endothelial Corneal Dystrophy
Predictive Factors of Good Results After Primary Descemet's Membrane Endothelial Keratoplasty (DMEK)
Aim: Identify predictive factors of good results after primary Descemet's Membrane Endothelial Keratoplasty (DMEK) in Fuchs Endothelial Corneal Dystrophy (FECD).
- Trial name
- GOODRMEK (NCT04469933)
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
DALK Corneal Transplant, Keratoconus
Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)
A prospective comparison between standard deep anterior lamellar keratoplasty (S-DALK) performed manually using a blade (trephine) and femtosecond laser-enabled deep anterior lamellar keratoplasty (IE DALK), where incisions are…
- Conditions
- DALK Corneal Transplant, Keratoconus, Scar
- Trial name
- NCT03732599
- Testing
- Standard Deep Anterior Keratoplasty (S-DALK), IE-DALK (femtosecond)
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Keratoconus
First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus
This Study is a First In Human clinical investigation addressed to evaluate the safety and efficacy of a novel intra-corneal nitinol device (Investigational Medical Device: GROSSO® implant) for the treatment of advanced…
- Trial name
- NCT06451718
- Testing
- Nitinol net for intracorneal implant for keratoconus treatment
- Where
- 2 sites in Italy, Spain
- Volunteers
- 12 people
- Sponsor
- Recornea Srl
Keratoplasty, Regional Block
Comparative Study Between Dexamethasone Versus Magnesium Sulfate in Medial Episcleral Technique in Keratopalsty Surgeries
The aim of this work is to compare between the effects of addition of Dexamethasone versus magnesium sulfate to local anesthetic mixture in medial episcleral technique in keratoplasty operations
- Trial name
- NCT07847489
- Testing
- Bupivacaine hydrochloride, Dexamethasone, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University