Clinical trials: Ketamine
Major Depressive Disorder, Suicide
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in youth and young adults (15-34 years).
- Conditions
- Major Depressive Disorder, Suicide, Treatment Resistant Depression
- Trial name
- Ket-CBT (NCT06480500)
- Testing
- Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- University Health Network, Toronto
Rett Syndrome
Esketamine for the Treatment of Rett Syndrome
The goal of this interventional study is to learn about the efficacy and safety of Esketamine for treating children with Rett syndrome (RTT).
- Trial name
- NCT06199700
- Testing
- Esketamine hydrochloride
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Children's Hospital of Fudan University
Bipolar Depression
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression
The purpose of the study is to determine the efficacy, safety and pharmacokinetics of inhaled Esketamine in participants with treatment-resistant bipolar depression (TRBD).
- Trial name
- NCT03965871
- Testing
- Esketamine DPI - low dose, Esketamine DPI - medium dose, Esketamine DPI - high dose
- Where
- 12 sites in Poland
- Volunteers
- 88 people
- Sponsor
- Celon Pharma SA
Depression, Unipolar, Depression, Bipolar
IM Ketamine vs Midazolam for Suicidal ER Patients
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide.
- Conditions
- Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
- Trial name
- NCT04640636
- Testing
- Ketamine hydrochloride injection, Midazolam injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Post-Traumatic Stress Disorder
Imaging SV2A in Mood Disorders
This study is designed to examine SV2A density in MDD and PTSD as a correlate of synaptic density, and to determine whether ketamine administration will reverse the synaptic loss in vivo in human subjects.
- Trial name
- NCT02734602
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yale University
Unipolar Depression
Ketamine Trial for the Treatment of Depression
This study is a Randomized Controlled Trial, investigating the safety and efficacy of administration of ketamine as a potential treatment for depression.
- Trial name
- NCT02401139
- Testing
- Ketamine
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
Depressive Disorder, Treatment-Resistant
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression
The purpose of this study is to evaluate the efficacy and safety of switching elderly participants with treatment-resistant depression (TRD) from a prior antidepressant treatment (to which they have not responded) to either…
- Trial name
- TRANSFORM-3 (NCT02422186)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant)
- Where
- 69 sites in United States, Belgium and 10 more
- Volunteers
- 139 people
- Sponsor
- Janssen Research & Development, LLC
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Postoperative Pain
Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute…
- Trial name
- NCT07063108
- Testing
- Esketamine hydrochloride, Saline
- Volunteers
- 276 people
- Sponsor
- Chinese PLA General Hospital
Laminectomy
The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy
The purpose of this research is to determine the pain-reducing effects of ketamine (Ketalar, an FDA-approved drug for anesthesia) and methadone (Dolophine, a long-acting narcotic) after lumbar laminectomy.
- Trial name
- NCT02252432
- Testing
- Ketamine, Methadone, Ketamine + methadone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Cedars-Sinai Medical Center
Dentofacial Deformities, Analgesia
Effects of Local Ketamine in Orthognathic Procedures
Orthognathic surgery is performed to correct congenital, developmental, or trauma-related skeletal deformities of the maxilla and mandible.
- Conditions
- Dentofacial Deformities, Analgesia, Vomiting, Postoperative, Nausea, Postoperative
- Trial name
- NCT07066306
- Testing
- Ketamine, Articaine Hydrochloride + Epinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Analgesia, Patient-controlled, Spinal Stenosis
The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam
Introduction Ketamine is an old and generally well accepted analgesic used in the intra- and perioperative setting. Several studies demonstrated the effectiveness of ketamine in the postoperative setting.
- Trial name
- NASKEMI (NCT01275547)
- Testing
- s-ketamine & midazolam, Morphine PCA
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression
Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
This study is looking at the mechanisms underlying the behavioral effects of ketamine in healthy and depressed individuals.
- Trial name
- NCT02037035
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yale University
Treatment Resistant Depressive Disorder
Ketamine for Treatment Resistant Late-Life Depression
The purpose of this study is to examine the effectiveness of a single infusion of ketamine (KET), to determine which dose is optimal 7 days after infusion using Bayesian Adaptive Randomization, and to learn about how ketamine…
- Trial name
- NCT02556606
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Neuropathic Pain
Study of NMDA Antagonists and Neuropathic Pain
The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity.
- Trial name
- NMDA (NCT01602185)
- Testing
- Dextromethorphan (drug used like antitussive), Memantine (drug used in Alzheimer's disease)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Clermont-Ferrand
Depressive Disorder, Major
A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder
The primary purpose of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release (XR), both in combination with a continuing selective serotonin reuptake…
- Trial name
- ESCAPE-TRD (NCT04338321)
- Testing
- Esketamine 28 mg, Esketamine 56 mg, Esketamine 84 mg
- Where
- 171 sites in Argentina, Austria and 22 more
- Volunteers
- 676 people
- Sponsor
- Janssen-Cilag International NV
Pain Management, Laparascopic Sleeve Gastrectomy
Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery
Shoulder pain is a well-recognized complaint following laparoscopic surgery. It is underlying mechanism has various causes, therefore, modalities in management and prevention of this sort of pain are numerous with different…
- Trial name
- NCT07429916
- Testing
- Intraoperative ketamine
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- King Abdullah University Hospital
PONV, Opioid Sparing Anaesthesia
Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery
In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and…
- Trial name
- NCT04706897
- Testing
- Dexmedetomidine, ketamine and lidocaine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Pain, Acute, Pain, Chronic
Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
Postoperative pain after thoracic surgery is associated with adverse outcomes. The current strategy to prevent postoperative pain is the use of regional anesthesia and analgesic agents.
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT03280017
- Testing
- Ketamine, Normal saline
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Mahidol University
Descending Aortic Dissection, Postoperative Pain
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving…
- Conditions
- Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
- Trial name
- 2020Ketamine (NCT04600089)
- Testing
- Saline, Ketamine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Eric Johnson
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