Clinical trials: Ketamine
Major Depressive Episode, Unipolar Depression
Ketamine as an Adjunctive Therapy for Major Depression
Randomised, controlled, parallel-group, pilot clinical trial of ketamine vs. midazolam as an adjunctive therapy for depression. The main purpose of the pilot study is to assess trial processes to help inform a future definitive…
- Conditions
- Major Depressive Episode, Unipolar Depression, Bipolar Depression
- Trial name
- KARMA-dep (NCT03256162)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- St Patrick's Hospital, Ireland
Ketamine-Induced Brain Activity Changes, Psychotic-like Symptoms
Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults
The purpose of this study is to determine whether ketamine-induced brain activity changes are modulated by TAK-063 administration using neuroimaging battery tests.
- Trial name
- NCT01892189
- Testing
- Ketamine, TAK-063
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Takeda
Pain, Postoperative
Effect of Ketamine on Analgesia Post-Cardiac Surgery
Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving…
- Trial name
- NCT02925858
- Testing
- Normal Saline Flush, 0.9% Injectable Solution_#1, Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Jewish General Hospital
Major Depression
Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
This study is examining the safety and effectiveness of two medications, ketamine and riluzole, in treating patients with treatment resistant major depressive disorder.
- Trial name
- NCT00419003
- Testing
- Lamotrigine, Ketamine, Riluzole
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Baylor College of Medicine
Depressive Disorder, Treatment-Resistant
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression
The purpose of this study is to assess the efficacy of intranasal esketamine plus an oral antidepressant compared with an oral antidepressant (active comparator) plus intranasal placebo in delaying relapse of depressive symptoms…
- Trial name
- SUSTAIN-1 (NCT02493868)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 155 sites in United States, Belgium and 13 more
- Volunteers
- 719 people
- Sponsor
- Janssen Research & Development, LLC
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcoholism
Ketamine/Placebo Family History Positive Study
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism.
- Trial name
- NCT00588952
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression, Delirium
Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
This study is geared toward characterizing the recovery of brain activity and cognitive function following treatments of electroconvulsive therapy and ketamine general anesthesia.
- Conditions
- Depression, Delirium, Seizures, Cognitive Disorders
- Trial name
- RCC2 (NCT02761330)
- Testing
- Ketamine, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Adjunctive Treatment of Major Depressive Disorder
A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study
The clinical trial is a Phase 2, double-blind, randomized, placebo controlled study in Major Depressive Disorder (MDD) participants currently treated with antidepressant therapy.
- Trial name
- NCT04103892
- Testing
- CLE-100
- Where
- 46 sites in United States, Puerto Rico
- Volunteers
- 146 people
- Sponsor
- Clexio Biosciences Ltd.
The Pk of IV Ketamine in Children With Heart Disease
Pharmacokinetics of Ketamine in Infants and Children
Dosing of medications is based on the plasma level achieved with a given dose and how long the medicine remains in the body. This study is called pharmacokinetics-that is, what the body does to the medication.
- Trial name
- NCT00553839
- Testing
- ketamine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Pain
SNAP VS BIS(OAA/S) Scale During a Sedation Regimen With and Without Ketamine
The study question: Does the SNAP-Index (SI) correlates better with the OASS than the BIS Monitor during sedation with ketamine? The study hypothesis: Since the SNAP II monitor seems to be more responsive during emergence of…
- Trial name
- NCT01250418
- Testing
- Ketamine group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Pain
Pediatric Ketamine Study for Pain Management
Direct comparison of intranasal sub-dissociative dose ketamine with intranasal fentanyl for the treatment of moderate to severe pain in pediatric patients in the emergency department.
- Trial name
- NCT02388321
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Antonios Likourezos
Depression
Ketamine Anesthesia in Electroconvulsive Therapy
Does the use of ketamine as the anesthetic medication in electroconvulsive therapy (ECT) accelerate the antidepressant effect of ECT? The study hypothesis was that depressed subjects receiving ECT with ketamine as the anesthetic…
- Trial name
- NCT01367119
- Testing
- Ketamine, methohexital
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Depressive Disorder, Treatment-Resistant
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression
The purpose of this study is to assess the safety and tolerability of esketamine nasal spray in participants with treatment-resistant depression (TRD).
- Trial name
- SUSTAIN-3 (NCT02782104)
- Testing
- Esketamine Nasal Spray
- Where
- 173 sites in United States, Argentina and 24 more
- Volunteers
- 1,148 people
- Sponsor
- Janssen Research & Development, LLC
Blood Pressure
A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
This is a pilot study to compare the hemodynamic changes that occur during induction with a novel drug combination known as ketofol (propofol and ketamine admixture with that of propofol alone (prototypic anesthesia induction…
- Trial name
- NCT01065350
- Testing
- Propofol, Ketamine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mayo Clinic
Sedation
Alternative Sedation During Bronchoscopy
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy.
- Trial name
- DEX (NCT01158820)
- Testing
- Dexmedetomidine load, Ketamine load, Midazolam load
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
ADNP Syndrome
Low-Dose Ketamine in Children With ADNP Syndrome
This is a Phase 2A, single dose, open-label study to evaluate the safety, tolerability, and efficacy of a low-dose, 40-minute infusion into the veins (intravenous infusion or "IV") of ketamine in children with ADNP syndrome…
- Trial name
- NCT04388774
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alexander Kolevzon
Depression
Intravenous Ketamine Plus Neurocognitive Training for Depression
This study has two aims: 1) to characterize the effects of intravenous ketamine on neurocognitive markers in depressed patients; 2) to test the efficacy of a synergistic intervention for depression combining intravenous ketamine…
- Trial name
- NCT03237286
- Testing
- Intravenous ketamine, Computer-based Cognitive Training
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Rebecca Price
Otolaryngeal Cancer
Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients
The goal of this prospective randomized double blinded placebo controlled study is to investigate if a single dose of ketamine in addition to standard anesthesia will reduce the risk of delirium in otolaryngeal cancer patients…
- Trial name
- NCT03040024
- Testing
- Ketamine, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Emory University