Clinical trials: Ketone Body Metabolism
Parkinson Disease, Lewy Body Dementia
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones
Small exploratory open-label pilot study to assess supplementation of a ketone ester (KetoneAid) as a potential therapy for persons with Parkinson disease (PD), Parkinson Disease Dementia/Lewy Body Dementia (PDD/LBD), and healthy…
- Conditions
- Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia
- Trial name
- NCT05778695
- Testing
- Ketone Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Heart Failure, Type 2 Diabetes Mellitus
Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1
To examine the effect of an increase in plasma beta-hydroxy-butyrate (B-OH-B) levels, spanning the physiologic and pharmacologic range (+0.5, +2.0, and +5.0 mmol/L), on: (i) parameters of left ventricular (LV) systolic and…
- Trial name
- Protocol1 (NCT03560323)
- Testing
- Beta-hydroxy-butyrate
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy
Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion
Background: Humans naturally produce ketone bodies under daily living conditions. The main ketone bodies are two functioning acids, beta-hydroxybutyric acid (3-OHB) and acetoacetate, and the pH-neutral, but odorous, acetone.
- Trial name
- NCT02655263
- Testing
- Somatropin, Ketone bodies
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
Recent research reveals intriguing results concerning the role of exogenous lactate and the ketone body 3-hydroxybutyrate (3-OHB) as therapeutic tools to combat obesity and related conditions.
- Trial name
- MetaLaKe (NCT05917873)
- Testing
- LaKe Ester
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ketone Body Metabolism, Brain Metabolism
Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study
This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and…
- Trial name
- NCT02357550
- Testing
- ketone
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Appetite
Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure
Background: Popular weight loss plans often restrict carbohydrates or fat. Research shows that very-low-carbohydrate (ketogenic) diets lead to greater weight loss than low-fat diets.
- Conditions
- Obesity, Appetite, Healthy Volunteers
- Trial name
- NCT01967563
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Migraine, Overweight and Obesity
Very Low Calories Ketogenic Diet in Migraine.
Ketogenesis is a physiologic phenomenon due to starvation or ketogenic diet (KD), a drastic restricted carbohydrate dietary regimen that induces lipid metabolism and ketone body (KB) synthesis.
- Trial name
- Ketomig (NCT03076060)
- Testing
- Ketogenic diet
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Roma La Sapienza
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
Obesity, Body Weight
Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation
Background: Time restricted eating (TRE) is a form of fasting in which a person eats only during a set window of time, which is usually between 4 and 10 hours each day.
- Trial name
- NCT06169137
- Testing
- Early Time-Restricted Eating, Conventional dietary regimen (12-hr, 9:30a-9:30p)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Cognitive Change
Effects of Weight Loss Management on Cognitive Function in Elderly Women With Obesity
According to studies, the risk of cerebrovascular disease and cognitive decline are associated with age-related changes. In addition, there is data suggesting a relationship between the progression of this pathology and the…
- Trial name
- NCT05841173
- Testing
- "PanTrek", Physical Trainings, Diet
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Federal State Budgetary Scientific Institution
Type2 Diabetes, Ketonemia
Effects of Ketone Bodies on Cognition in Type 2 Diabetes
Diabetes negatively affects cognition and increases the risk of developing overt dementia. Decreased cerebral glucose metabolism may be contributing to this effect, thus providing a glucose substitute using ketone bodies might…
- Conditions
- Type2 Diabetes, Ketonemia, Cognitive Change
- Trial name
- KETOCOGNITION (NCT03657537)
- Testing
- Ketone infusion, Saline infusion
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Bispebjerg Hospital
Asthma, Obesity
Nutrition for Asthmatics with Obesity
This study will test the effect of diet on asthma in individuals with obesity.
- Trial name
- NCT05222451
- Testing
- DGA Diet, MCT Diet, KETO Diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pennington Biomedical Research Center
Heart Failure With Reduced Ejection Fraction, Heart Failure
Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure
In a randomized, double-blind, placebo-controlled cross-over design, subjects will either receive a supplemental drink containing a commercially available ketone ester (DeltaG®, 500 mg/kg body weight), or a taste matched…
- Trial name
- KETONE-HF (NCT05348460)
- Testing
- Ketone ester drink (DeltaG®, 500 mg/kg body weight)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Migraine, Ketogenic Dieting
Th Effect of Ketogenic Metabolic Nutritional Pattern on High-frequency Episodic Migraine (EMIKETO)
The study aims to investigate the impact of 2 nutritional patterns on high-frequency episodic migraine. Subjects enrolled will be randomized in two arms: a) very-low-calorie-ketogenic-diet (VLCKD), b) hypocaloric balanced non…
- Conditions
- Migraine, Ketogenic Dieting, Weight Loss, Overweight
- Trial name
- EMIKETO (NCT04360148)
- Testing
- very-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- New Penta SRL
Migraine, Episodic Migraine
Energy for the Brain
Approx. one billion people are suffering from migraine worldwide and yet, therapeutic options are still very limited. Research suggests that changes in energy metabolism could be part of migraine pathophysiology.
- Trial name
- MigraKet (NCT03132233)
- Testing
- Beta-hydroxybutyrate calcium and magnesium salt
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
Ketosis, Blood Hormones
The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males
This study investigates how orally ingested exogenous ketone monoester supplements affect circulating hormone concentrations in healthy young adult males after a single session of resistance exercise.
- Conditions
- Ketosis, Blood Hormones, Testing Effect of Intervention, Resistance Exercise
- Trial name
- NCT06683547
- Testing
- Ketone Monoester (KET), Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McGill University
Obesity, Overweight and Obesity
Ketones Supplementation and Postprandial Lipemia
This study determines whether different forms of ketones supplemented prior to a meal lower the triglyceride (fat) content in the blood of overweight and obese individuals.
- Conditions
- Obesity, Overweight and Obesity, Overweight, Triglycerides High
- Trial name
- NCT03729934
- Testing
- Ketone Ester, Ketone Salt
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Medium-chain Acyl-CoA Dehydrogenase Deficiency
Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals
The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and…
- Trial name
- MEMCADD (NCT06623032)
- Testing
- Medium-Chain Fatty Acid (MCFA), Long-Chain Fatty Acid (LCFA)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nutrition, Ketogenic Diet
Dietary Macronutrients and Gut Microbiota, Inflammation, and Metabolic Markers
This 12-week randomized controlled trial will investigate the effects of dietary patterns with different macronutrient compositions on gut microbiota, intestinal inflammation, gene expression, and metabolic health in healthy…
- Conditions
- Nutrition, Ketogenic Diet, Gene Expression, Diet
- Trial name
- DIETMICRO (NCT07672691)
- Testing
- Ketogenic Diet (KD), Vegetarian Diet (VD), Control Diet (CD)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice