Clinical trials: Ketones, Metabolism
Diabetes Mellitus, Ketosis
The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes
What is the effect of a ketone drink on liver glucose production, and postprandial glycemia, in people with type 2 diabetes.
- Trial name
- KES2 (NCT05518448)
- Testing
- Ketone - beta-hydroxybutyrate (β-OHB)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Exeter
Hypoglycaemia
Point of Care Ketone Measurement in the Newborn
Low blood sugar levels are common in babies after birth. This may be normal as babies can use other sources of energy. However if a baby does not produce these fuels the brain can be starved of energy and be damaged.
- Trial name
- POCKET (NCT02341313)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Kathryn Beardsall
Diabetic Ketoacidosis
Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care
In this KARMA2 feasibility study the investigators are testing whether ambulance staff can reliably and safely identify patients at high risk of diabetic ketoacidosis using blood ketone meters and start fluid (saline) therapy…
- Trial name
- KARMA2 (NCT04940897)
- Testing
- Use of CareSens ketone meter
- Where
- United Kingdom
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- East of England Ambulance Service NHS Trust
Exercise, Hypoxia
Effect of Oral Ketone and Sodium Bicarbonate Administration During Endurance Exercise in Hypoxia
This study is investigating the effects of oral ketone and sodium bicarbonate administration on physiological and metabolic parameters during cycling endurance exercise in hypoxia.
- Trial name
- NCT04579770
- Testing
- Ketone ester, Sodium bicarbonate
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Ketosis, Metabolic, Immune Functions
The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.
- Conditions
- Ketosis, Metabolic, Immune Functions, Histone Deacetylase (HDAC) Activity
- Trial name
- Acute_Ketone (NCT06590623)
- Testing
- Ketone Monoester (KE)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion
Background: Humans naturally produce ketone bodies under daily living conditions. The main ketone bodies are two functioning acids, beta-hydroxybutyric acid (3-OHB) and acetoacetate, and the pH-neutral, but odorous, acetone.
- Trial name
- NCT02655263
- Testing
- Somatropin, Ketone bodies
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ketosis
Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies
One important difference between KE compounds is the ketone-promoting components, which determines the circulating ratio of blood ketone bodies, BHB and AcAc, and may in turn lead to important metabolic and signaling differences.
- Trial name
- STAK: OK'd (NCT05501366)
- Testing
- Ketone Supplement, Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale, Blood Draw
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Parkinson Disease, Lewy Body Dementia
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones
Small exploratory open-label pilot study to assess supplementation of a ketone ester (KetoneAid) as a potential therapy for persons with Parkinson disease (PD), Parkinson Disease Dementia/Lewy Body Dementia (PDD/LBD), and healthy…
- Conditions
- Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia
- Trial name
- NCT05778695
- Testing
- Ketone Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Ketosis
Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid
It is well established that the brain is capable of consuming ketone bodies, especially during low glucose availability, e.g. fasting.
- Trial name
- KetoBrain (NCT06318299)
- Testing
- Ketone Ester
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ketosis, Keto Acidosis
Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'
Rationale: During perioperative period, prolonged starvation, surgical stress, acute complications (e.g. infection) and medication changes all promote ketone generation, therefore increasing the risk of ketoacidosis.
- Conditions
- Ketosis, Keto Acidosis, Ketoses, Metabolic, Ketosis, Diabetic
- Trial name
- DKAP (NCT05225467)
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ketosis
Metabolomic Signature of Exogenous Ketosis
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet.
- Trial name
- KM (NCT05699707)
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes Mellitus, Glucose
The GLOW Study - The YANG System
This is an open label, interventional, monocentric, prospective early feasibility study, designed to evaluate the safety of implant and short-term integration into the tissue of the YANG sensor.
- Trial name
- NCT04782934
- Testing
- The YANG SENSOR is an active implantable device, for Real Time Continuous Glucose, Lactate and Ketone Measurement
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indigo Diabetes NV
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Ketoses, Metabolic, Ketogenic Dieting
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after…
- Conditions
- Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging
- Trial name
- KAM (NCT06065657)
- Testing
- Ketone Supplement, Control Diet, Ketogenic diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 1 Diabetes, Type 2 Diabetes
Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D)…
- Trial name
- KARMA (NCT07421518)
- Testing
- SGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
- Trial name
- NCT06173973
- Testing
- Kenetik; Ketone Concentrate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
MELAS Syndrome, Mitochondrial Diseases
Ketones & Mitochondrial Heteroplasmy
The current study is a prospective evaluation of the ability of ketosis to shift mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known mutation in their mtDNA at position 3243 (A>G).
- Trial name
- NCT01252979
- Testing
- Medium-Chain Triglycerides
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The University of Texas Health Science Center, Houston
Aging
Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults
The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in adults aged 60 to 80 with stable health.
- Trial name
- NCT06068803
- Testing
- Ketone drink
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Energy Supply; Deficiency, Carbohydrate Availability
Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area.
- Trial name
- NCT05551455
- Testing
- Nutritional/dietary intake manipulation ('Normal'), Nutritional/dietary intake manipulation ('Low')
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University