Clinical trials: Ketorolac
Cataracts
A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom or Nevanac.
- Trial name
- NCT01021761
- Testing
- Ketorolac Tromethamine, Bromfenac, nepafenac
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Cataracts
A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom, or Nevanac.
- Trial name
- NCT01001806
- Testing
- Ketorolac Tromethamine 0.45%, bromfenac 0.09%, nepafenac 0.1%
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Knee Osteoarthritis
Ketorolac Versus Triamcinolone Knee Injections for Osteoarthritis
Osteoarthritis is a disabling disease of the joint spaces and has a high impact on society due to the amount of people who are affected by the disease. Nonoperative management is a mainstay of therapy in most patients.
- Trial name
- NCT02295189
- Testing
- Ketorolac Tromethamine, Triamcinolone Acetonide
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Healthy Volunteers
Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers
This was a phase 1, open label, multiple dose study in healthy male and female volunteers. Subjects received intranasal ketorolac tromethamine (30 mg) three times daily (t.i.d.) for three days (seven doses in total).
- Trial name
- NCT01363050
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Pain, Postoperative, Phimosis
An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision
Circumcision is the most common surgical procedure performed by Pediatric Urologists. Ketorolac has been shown to have an efficacy similar to morphine in multi-modal analgesic regimens without the commonly associated adverse…
- Conditions
- Pain, Postoperative, Phimosis, Paraphimosis, Balanitis
- Trial name
- NCT04646967
- Testing
- Bupivacain, Sevoflurane, Acetaminophen
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Pain Management
Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain
Bupivacaine is the most widely used local anesthetic agent across majority of the Cardiac Implantable Electronic device (CIED) implant procedures in the United States.
- Trial name
- NCT05575999
- Testing
- Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Hand Injuries With Intravenous Regional Anesthesia
Early Versus Late Deflation of Distal Tourniquet in IVRA With and Without Ketorolac in Hand & Forearm Surgery
Bier block , or intravenous regional anesthesia (IVRA), is a method of anesthesia for upper extremity surgeries. IVRA was first described by August Bier in 1908, and after a period of latency, it began to gain widespread use…
- Trial name
- NCT05234619
- Testing
- Group one ( lidocaine or control LE ) Early deflation, Group two ( lidocaine , ketorolac LKE ) Early deflation, Group three ( lidocaine or control LL ) Late deflation
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
IUD Insertion Pain
Oral Ketorolac for IUD Pain Reduction
To determine if oral ketorolac given at different timepoints prior to intrauterine device (IUD) insertion influences pain experienced during this procedure.
- Trial name
- NCT06853327
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Febrile Morbidity, Pain
Post-Operative Treatment With Ketorolac After Abdominal Myomectomy
The purpose of this study is to determine if ketorolac, given after abdominal myomectomy, will decrease the frequency of post-oerative fevers as well as improve post-operative pain management.
- Trial name
- NCT00845754
- Testing
- ketorolac, saline
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Headache
A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache
This randomized, double-blind trial will compare the clinical efficacy of IV acetaminophen to that of IV ketorolac as adjuncts to standard therapy (prochlorperazine and diphenhydramine) in the treatment of patients presenting to…
- Trial name
- NCT03472872
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Corewell Health South
Myofascial Pain
TPI Medication Comparison - Ketorolac, Lidocaine, or Dexamethasone
Hypothesis The main hypothesis of this study is that anti-inflammatory medications (ketorolac or dexamethasone) will provide longer-lasting and greater pain relief than just lidocaine in trigger point injections where a local…
- Trial name
- NCT03028012
- Testing
- Ketorolac, Lidocaine, Dexamethasone
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Full Thickness Rotator Cuff Tear, Rotator Cuff Tendinitis
Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial
The purpose of this study is to compare the functional outcomes of patients with shoulder pathology treated with either ketorolac or corticosteroid injections, in a randomized double-blinded study.
- Trial name
- NCT04115644
- Testing
- Ketorolac, Kenalog
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Michael Khazzam
DME
Short-term Additive Effect of Topical Ketorolac on the Management of Diabetic Macular Edema With Intravitreal Bevacizumab
Purpose: To evaluate the short-term effect of adding topical ketorolac to the management of diabetic macular edema (DME) with intravitreal bevacizumab (IVB).
- Trial name
- NCT04119921
- Testing
- prescription topical ketorolac in group 1, prescription artificial tear in group 2, prescription topical ketorolac in group 2
- Where
- Iran
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Analgesic Adverse Reaction
Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy
This prospective, randomized, double blinded study is designed to compare the bleeding rates of ketorolac vs. placebo when used for post tonsillectomy pain control in pediatric patients ages 2-18.
- Trial name
- NCT03453541
- Testing
- Ketorolac Tromethamine, 0.9% Normal Saline
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Pain
Intramuscular Ketorolac Versus Oral Ibuprofen for Pain Relief in First Trimester Suction Curettage
The aim of this study is to compare the effect of pre-procedural ketorolac to ibuprofen on immediate post-procedural pain scores in patients undergoing first trimester suction curettage with local anesthesia only.
- Trial name
- NCT01595282
- Testing
- Ketorolac, Ibuprofen
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Healthy Subjects
Assessment of Nasal Deposition and Clearance of Ketorolac Solution Administered Using the Valois Nasal Spray Device
This was a randomised three-way crossover design study. The study consisted of three study periods each separated by a minimum 44 hour washout period.
- Trial name
- NCT01356212
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Headache, Migraine
Intranasal Ketorolac Trial
The purpose of this study is to determine if intranasal (IN) Ketorolac in combination with oral Prochlorperazine and Diphenhydramine is non-inferior to current migraine management which involves use of intravenous (IV) Ketorolac…
- Trial name
- NCT06083571
- Testing
- Ketorolac, Prochlorperazine, Diphenhydramine
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Hysterectomy, Gynecologic Surgical Procedures
Intraperitoneal Infusion of Analgesic for Postoperative Pain Management
The study is a prospective, double-blinded, placebo-controlled multi-center trial to measure if postoperative pain and the amount of narcotics used are reduced by a clinically significant amount in women undergoing minimally…
- Conditions
- Hysterectomy, Gynecologic Surgical Procedures, Narcotic Use, Pain, Postoperative
- Trial name
- ON-Q (NCT04130464)
- Testing
- Ropivacaine Infusion from ON-Q Pump, Ropivacaine + Ketorolac Infusion from ON-Q Pump, Normal Saline Infusion from ON-Q Pump
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ying Liu
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California