Clinical trials: Ketosis, Metabolic
Diabetic Ketoacidosis
Two Bag System for Diabetic Ketoacidosis
This is a study investigating the best way to treat diabetic ketoacidosis (DKA) with intravenous (IV) fluids in the hospital. The purpose of this study is to determine whether the "two bag" system of administering IV fluids for…
- Trial name
- 2BagDKA (NCT03660189)
- Testing
- Two bag system
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- MetroHealth Medical Center
Overweight, Obesity
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem.
- Trial name
- NCT06044935
- Testing
- Standard Diet, Ketogenic Diet, Nicotinamide Riboside
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Diabetic Ketoacidosis
REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis
A number of scientific papers have been published on the efficacy and safety of adding REAMBERIN® (meglumin sodium succinate), a 1.5% infusion solution, to standard therapy for patients with diabetic ketoacidosis (DKA), which…
- Trial name
- NCT06955416
- Testing
- Reamberin
- Where
- 3 sites in Russia
- Volunteers
- 312 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
PTSD, Ketosis
Ketone Supplementation in Individuals With PTSD
The purpose of this study is to determine if a 6-week period of ketone salt supplementation affects physiological, emotional, cognitive, and/or behavioral health markers in individuals with PTSD.
- Trial name
- NCT04083352
- Testing
- Pruvit Ketomax Ketone Salt
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augusta University
Acute Ketosis
How Orally Consumed 3-hydroxybuturate Alters Metabolism
This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.
- Trial name
- NCT02917252
- Testing
- 3-hydroxybuturate
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
PCOS
Exogenous Ketone Ester in Women with Polycystic Ovary Syndrome.
Polycystic ovarian syndrome (PCOS) is characterized by elevated androgens such as testosterone. Clinical studies suggest that ketogenic diets lower the levels of androgens.
- Trial name
- NCT05762822
- Testing
- 3-OHB (KE4), water
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
Heart Failure, Ketosis
Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure
We aim to investigate the hemodynamic effects of weight-adjusted dosing of ketone monoester en patients with chronic heart failure.
- Trial name
- KINETICS2 (NCT04594265)
- Testing
- KetoneAid KE4 Pro Monoester, Science in Sport Go Enegy
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, Type 1
cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstances
Collection of venous blood samples in 50 persons with type 1 diabetes to evaluate the behavior of different biomarkers (glucose, lactate, beta-hydroxybutyrate), and hormones (cortisol, growth hormone) during and after one morning…
- Trial name
- ACT-ONE (NCT05429359)
- Testing
- CPET: CardioPulmonary Exercise Test for CSII users, AEX1: Aerobic Exercise Test 1 for CSII users, AEX2: Aerobic Exercise Test 2 for CSII users
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Alzheimer's Disease
Tricaprilin in Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and effectiveness of tricaprilin administered once a day for ninety days in subjects with mild to moderate, probable Alzheimer's disease.
- Trial name
- NCT00142805
- Testing
- Tricaprilin
- Where
- 25 sites in United States
- Volunteers
- 152 people
- Sponsor
- Cerecin
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Tourette Syndrome
Pilot Study of the Modified Atkins Diet for Tourette Syndrome
Pharmacotherapy has long been considered the primary approach for tic suppression in Tourette syndrome (TS). Unfortunately, medications are often ineffective and frequently have significant side-effects.
- Trial name
- NCT00952601
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Type 2 Diabetes, Ketonemia
Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy
The use of sodium glucose co-transporter 2 inhibitors (SGLT2i) has been associated with increased serum ketone levels. However, most previous studies included subjects who were either insulin or even drug naïve with relatively…
- Trial name
- NCT03959501
- Testing
- Dapagliflozin 10 mg, Sitagliptin 100mg
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Nutritional and Metabolic Diseases, Prediabetes
LIfestyle MEtabotype Study B (LIME-B)
Glycemic responses vary significantly among individuals, even when consuming identical foods or meals, but the factors predicting individual glucose responses to food intake remain poorly investigated.
- Conditions
- Nutritional and Metabolic Diseases, Prediabetes, Type 2 Diabetes
- Trial name
- LIME-B (NCT07888257)
- Testing
- βHB drink (ketone ester), Carbohydrate drink
- Where
- 2 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Diabetic Ketoacidosis, Acute Kidney Injury
Risk Factors and Outcomes of Acute Kidney Injury in Patients With Diabetic Ketoacidosis at Sohag University Hospital.
Diabetic ketoacidosis (DKA), a severe complication of diabetes mellitus (DM), is the leading cause of hospitalization, morbidity and mortality in patients with DM (1).
- Trial name
- NCT05867797
- Volunteers
- 100 people
- Sponsor
- Sohag University
Gastroenteritis, Diabetes Mellitus (Ketoacidosis)
Non-invasive Assessment of the Current State of Hydration in Children by Ultrasound
Children with clinical signs of severe dehydration will be examined by ultrasound in a supine position during admission. Children aged between 1 and 15years will be divided into three weight groups: 10-20kg, 20-30kg, 30-50kg.
- Trial name
- NCT04463082
- Testing
- Intravenous administration of fluids
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava