Clinical trials: Kidney; Disease, Acute
Sepsis, Septic Shock
Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Injury
The primary objective of this study is to investigate whether using SGLT2i may be associated with decreased incidence of sepsis-induced AKI or not.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06902493
- Testing
- No intervention
- Where
- Saudi Arabia
- Volunteers
- 664 people
- Sponsor
- University of Jazan
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Hematologic Malignancy, Acute Myeloid Leukemia
A Trial to Evaluate the Potential Impact of Renal Impairment on the Pharmacokinetics and Safety of CPX-351
This study evaluates the pharmacokinetics and safety of CPX-351 in patients with moderate or severe renal impairment.
- Conditions
- Hematologic Malignancy, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT03555955
- Testing
- CPX-351
- Where
- 13 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- Jazz Pharmaceuticals
Acute Kidney Injury
Acute Kidney Injury After Cardiac Arrest
The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.
- Trial name
- NCT06544538
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Acute Kidney Disease
Demethylating Agent Azacitidine on Prevention of Acute Kidney Injury-chronic Kidney Disease Continuum
Acute kidney injury (AKI) is increasing worldwide in recent years and is a major risk factor of chronic kidney disease (CKD). AKI, acute kidney disease (AKD) and CKD form a continuum whereby initial kidney injury leads to ongoing…
- Trial name
- NCT05325099
- Testing
- Azacitidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Conditions, Infections
Analysis of the Virtual Acute Care at Home Experience
The purpose of this study is to examine the implementation, intervention effectiveness, and dissemination of a digital acute care delivery model for improving selected health outcomes in the Hospital at Home population.
- Conditions
- Conditions, Infections, Heart Failure, Renal and Urinary Disorders
- Trial name
- HaH (NCT05952999)
- Testing
- Digital Care Solution as supportive personalized care, Traditional Hospital Level Care
- Where
- United States
- Volunteers
- 9,654 people
- Sponsor
- OSF Healthcare System
Proteinuria
Proteinuria During Acute Pyelonephritis In Pregnancy
The purpose of this research study is to compare the amount of protein excreted by the kidneys in a 24-hour period between patients who have a kidney infection and those who do not have a kidney infection.
- Trial name
- NCT02536638
- Testing
- Exposure to pyelonephritis
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- MemorialCare Health System
Multiple Myeloma, Acute Renal Failure
Trial of Plasma Exchange for Acute Renal Failure at the Onset of Myeloma
Background:Plasma exchange has been suggested to be of theoretical benefit in the treatment of acute renal failure at the onset of multiple myeloma. Two small-randomized trials provide conflicting evidence.
- Trial name
- NCT00120263
- Testing
- Plasma Exchange
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- London Health Sciences Centre
Renal Insufficiency, Acute, Renal Insufficiency, Chronic
Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency
This is a Phase 1, open-label, single-dose study of the safety, tolerability, and pharmacokinetics of Minocin® (minocycline) for injection in subjects with renal insufficiency.
- Conditions
- Renal Insufficiency, Acute, Renal Insufficiency, Chronic, Healthy Subjects
- Trial name
- NCT02808052
- Testing
- Minocin (minocycline) for Injection
- Where
- Germany
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Acute Kidney Injury
Use of Care Bundle in Acute Kidney Injury
This study is a service evaluation to assess the impact of compliance of Acute Kidney Injury care bundle (AKI-CB) on clinical and renal outcomes.
- Trial name
- NCT02534584
- Where
- United Kingdom
- Volunteers
- 944 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Acute Kidney Injury
Predictors of Acute Kidney Injury in Critically Ill Children Admitted to PICU.
Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year.
- Trial name
- NCT06328478
- Testing
- Observational prospective study.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury
Cystatin c: a Biomarker of AKI in Aneurysmal Subarachnoid Haemorrhage Patients
The goal of this observational study is to assess cystatin c as a predictive biomarker of early acute kidney injury in aneurysmal subarachnoid hemorrhage patients.
- Trial name
- NCT06635408
- Testing
- cystatin c
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Cardiac Surgery Associated - Acute Kidney Injury, AKI - Acute Kidney Injury
Safety & Efficacy of RenalGuard® Therapy in the Prevention of Cardiac Surgery Associated Acute Kidney Injury
The goal of this clinical trial is to assess the effect of RenalGuard Therapy in reducing the rates of Acute Kidney Injury (AKI) within 72 hours after cardiac surgery in patients at risk of developing Cardiac Surgery Associated…
- Trial name
- SAFEGUARD (NCT07123935)
- Testing
- RenalGuard® Therapy, Standard of Care (SOC)
- Where
- 2 sites in Malaysia
- Volunteers
- 300 people
- Sponsor
- CardioRenal Systems, Inc.
Kidney Tubular Necrosis, Acute
Allogeneic Multipotent Stromal Cell Treatment for Acute Kidney Injury Following Cardiac Surgery
The purpose of this trial is to determine if the administration of allogeneic MSCs at defined doses is safe in patients who are at high risk of developing significant Acute Kidney Injury (AKI) after undergoing on-pump cardiac…
- Trial name
- NCT00733876
- Testing
- Multipotent Stromal Cells, Administration of MSC
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- AlloCure Inc.
Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy
Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30
Intravascular iodinated contrast administration has become crucial to modern medicine. Currently it is estimated that over 250 million injections are given each year worldwide during medical scans and interventions.
- Conditions
- Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy, Renal Insufficiency
- Trial name
- MIRACLE (NCT04598516)
- Testing
- serum creatinine assay
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Heart Failure, Acute Kidney Injury
Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06341816
- Testing
- VEXUS score, NGAL
- Volunteers
- 100 people
- Sponsor
- Inonu University
Acute Kidney Injury
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The central hypothesis of this research study is that perioperative administration of the proton pump inhibitor (PPI) pantoprazole could reduce the development of acute kidney injury (AKI) following cardiac surgery by activation…
- Trial name
- P2 AKI PPI (NCT06706258)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia, Acute Kidney Injury
Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia
The main aim of this project is to elucidate the incidence of acute kidney injury (AKI) in newborns with congenital diaphragmatic hernia during stay in the Pediatric intensive care unit. (PICU).
- Conditions
- Congenital Diaphragmatic Hernia, Acute Kidney Injury, Multiple Organ Failure, Pulmonary Hypertension
- Trial name
- NCT06050525
- Where
- Sweden
- Volunteers
- 109 people
- Sponsor
- Karolinska Institutet
Acute Heart Failure
Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE)
Patients being hospitalized for acute heart failure and already receiving standard therapy will be randomized to receive either tolvaptan or placebo, based on the level of copeptin measured in their bloodstream.
- Trial name
- ACTIVATE (NCT01733134)
- Testing
- Tolvaptan
- Sponsor
- Maisel, Alan, M.D.
Hepatorenal Syndrome, Liver Cirrhosis
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
Patients with advanced cirrhosis of the liver develop kidney problems occasionally. This condition is called Hepatorenal Syndrome, requires hospitalization and frequently results in death.
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Trial name
- NCT06256432
- Testing
- Ambrisentan, Terlipressin
- Where
- 6 sites in India
- Volunteers
- 54 people
- Sponsor
- Noorik Biopharmaceuticals AG
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