Clinical trials: Kidney Disease, Chronic
Chronic Kidney Disease
A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease
This study is intended to investigate the usefulness of estimated glomerular filtration rate (eGFR) slopes derived from retrospective routine clinical practice data, compare those retrospective slopes with those generated in a…
- Trial name
- NCT04881448
- Testing
- collection of serum/capillary creatinine values
- Where
- 25 sites in United States, Germany and 2 more
- Volunteers
- 223 people
- Sponsor
- Boehringer Ingelheim
Diabetic Nephropathies, Diabetic Glomerulosclerosis
Transformative Research in Diabetic Nephropathy
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy.
- Trial name
- TRIDENT (NCT02986984)
- Testing
- There is no intervention
- Where
- 17 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
Heart Failure, Chronic Obstructive Pulmonary Disease
Effects of Remote Patient Monitoring on Chronic Disease Management
Remote patient monitoring is a potential component for the management of chronic conditions that may provide reliable and real-time physiological measurements for clinical decision support, alerting, and patient self-management.
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Chronic Kidney Disease, Uncontrolled Hypertension
- Trial name
- NCT03127852
- Testing
- Medly
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University Health Network, Toronto
End Stage Renal Disease, Inflammation
Permeability Enhancement to Reduce Chronic Inflammation
Chronic dialysis patients with end stage renal disease have an increased mortality rate as compared to the age matched healthy population.
- Trial name
- PERCI (NCT01582893)
- Testing
- HCO1100, P210H
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Vantive Health LLC
Chronic Kidney Disease
Low-protein Formula Supplements in Chronic Kidney Disease
Prospective randomized contorl study.Comparing clinical outcome between chronic kidney disease who were prescribed 6% low-protein nutrition supplement along with dietatian regular nutrition education and those without oral…
- Trial name
- NCT05318014
- Testing
- Intervention group, Regular nutrition education
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Taichung Veterans General Hospital
Chronic Kidney Disease Requiring Chronic Dialysis
a Randomized Controlled Trial of the Intake of Organic and Inorganic Phosphate in Peritoneal Dialysis Patients
Hyperphosphatemia is a common problem among patientens suffering from chronic kidney disease. Hyperphosphatemia is associated with increased risk of cardiovascular diseases.
- Trial name
- RCTOIP (NCT04600193)
- Testing
- Diet containing organic phosphate, Diet containing inorganic phosphate
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Copenhagen
Chronic Kidney Disease
The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity
This study evaluates the effect of oral sodium bicarbonate treatment on the intrarenal renin-angiotensin-system in adult patients with a metabolic acidosis and chronic kidney disease.
- Trial name
- BIC (NCT02896309)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Erasmus Medical Center
Chronic Kidney Disease, Hyperparathyroidism, Secondary
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
This study will evaluate the efficacy of CTAP101 Capsules versus placebo in reducing intact parathyroid hormone (iPTH) by at least 30% from pretreatment baseline; safety and tolerability of CTAP101 will also be evaluated
- Conditions
- Chronic Kidney Disease, Hyperparathyroidism, Secondary, Vitamin D Deficiency
- Trial name
- NCT01651000
- Testing
- CTAP101 30 μg capsules, Sugar pill to CTAP101 30 μg capsules
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- OPKO IP Holdings II, Inc.
Heart Failure, CKD
Effect of Roxadustat on Heart Failure Patients With Anaemia and Moderate-to-Severe Chronic Kidney Disease
Previous clinical observations of potential benefit from Roxadustat in this complex patient population prompted this investigation Therefore, the investigators designed this retrospective, observational study to thoroughly…
- Conditions
- Heart Failure, CKD, Anemia
- Trial name
- NCT07268807
- Testing
- Roxadustat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhongda Hospital
Ischemic Heart Disease, Heart Failure
Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance
In 2005, more then one-third of Canadians were burdened with one or more chronic diseases. Patients with one chronic disease often have, or are at risk for, another chronic disease.
- Conditions
- Ischemic Heart Disease, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- iCDM (NCT01342263)
- Testing
- iCDM
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- Simon Fraser University
Hyperphosphataemia, ESRD
Non-interventional Study to Evaluate the Ease of Reaching Individual Goals in Serum Phosphorus (Steering)
The objective of this non-interventional study is to confirm that with standard OsvaRen® treatment it is possible to achieve in at least 60% of the patients the levels of phosphorus, total calcium, and iPTH seen in the CALMAG…
- Trial name
- Steering (NCT01424787)
- Where
- 24 sites in Denmark, Germany and 2 more
- Volunteers
- 324 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using N-Acetylcysteine
The main purpose of the study is find whether the addition of N-acetylcysteine (antioxidant) to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II receptor…
- Trial name
- NCT00572663
- Testing
- ACC (N-acetylcysteine) 1200 mg
- Sponsor
- Medical University of Gdansk
Chronic Kidney Disease
Impact of Increased Water Intake in Chronic Kidney Disease
The investigators have designed a randomized controlled trial to test whether increased water intake slows renal decline in patients with Stage-III Chronic Kidney Disease.
- Trial name
- WIT (NCT01766687)
- Testing
- Hydration
- Where
- Canada
- Volunteers
- 822 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypertension, Chronic Kidney Disease
Effects of Aliskiren in Elderly Hypertensive Chronic Kidney Disease (CKD) Patients
The purpose of this study is to determine whether aliskiren is effective in the treatment of blood pressure, hear function, renal function in elderly hypertensive chronic kidney disease (CKD) patients.
- Trial name
- NCT01284114
- Testing
- Aliskiren
- Where
- 4 sites in Japan
- Volunteers
- 23 people
- Sponsor
- Jichi Medical University
End Stage Renal Disease
Brain Swelling During Dialysis
The proposed controlled, randomized study aims to compare pre-dilution hemodiafiltration (HDF) and low flux hemodialysis (HD) regarding acute changes in the brain. The study consist of two examination days placed one week apart.
- Trial name
- BRASE (NCT01396863)
- Testing
- HDF during the first examination, HD during the first examination
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Chronic Kidney Disease
Study of the Influence of Liver Function on Blood Concentrations of Runcaciguat in Participants With Different Degrees of Liver Impairment
Researchers are looking for a better way to treat people with chronic kidney diseases. Before a treatment can be approved for patients to take, researchers do clinical studies to better understand its safety and what happens to…
- Trial name
- NCT04820621
- Testing
- Runcaciguat (BAY1101042)
- Where
- Germany
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bayer
Anemia in Chronic Kidney Disease
A Real-World Study About Anemia in Chronic Kidney Disease in China（DASHENG）
Anemia affects the quality of life of CKD patients and increases the risk of CKD progression. we conducted a real-world study on patients with anemia in CKD to analyze the disease characteristics and treatment in Chinese patients…
- Trial name
- DASHENG (NCT07098416)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Wei Chen
Hypertension, Chronic Kidney Disease
Concordance Between Central Blood PRessure dEvices In Nephrology Patients
The most accurate way to determine intra-aortic BP is to obtain invasive measures by vascular catheterization, which is not possible to perform routinely during the regular follow-up of patients.
- Conditions
- Hypertension, Chronic Kidney Disease, Blood Pressure
- Trial name
- CBP-REIN (NCT05963880)
- Testing
- Brachial and Central BP measurements with Mobil-o-Graph NG device (IEM), WatchBP Office device (Microlife), BP+ device (Uscom) and Oscar 2 with SphygmoCor inside device (SunTech)
- Where
- Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Diabetes, Chronic Kidney Disease
Glycaemic Response to Oral Nutrition Support During Haemodialysis
Patients with kidney, or renal, failure require life-saving treatment with regular dialysis. Dialysis is a form of treatment that simulates some kidney functions; to remove harmful waste products and extra water from the blood.
- Conditions
- Diabetes, Chronic Kidney Disease, End Stage Renal Failure on Dialysis
- Trial name
- GRO-HD (NCT02989688)
- Testing
- Nepro HP (Abbott Nutrition), Fortisip compact protein 125 ml + Calogen 20ml (Nutricia), Fortisip compact 125 ml (Nutricia)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Kidney Diseases Receiving Anticoagulants
Frequency and Risk Factors of Bleeding in Patients With Chronic Kidney Disease Receiving Anticoagulants
1-Introduction: Chronic kidney disease (CKD) is a significant global public health issue, closely linked to cardiovascular disease (CVD).
- Trial name
- NCT06543927
- Testing
- serum creatinine, INR
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
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