Clinical trials: Kidney Failure,Chronic
End Stage Renal Disease on Dialysis, Hemodialysis Complication
Virtual Reality Intradialysis: Last vs. First Part of the Session
The main objective of this investigation is to assess if an intradialysis virtual reality exercise program during the last two hours of the hemodialysis session results in greater hemodynamic stability than exercise performed…
- Trial name
- VRI (NCT04046042)
- Testing
- Conventional exercise, Exercise during the last two hours of the hemodialysis session
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Diabetic Nephropathy Type 2 - Uncontrolled, Diabetes Mellitus, Type 2
Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in…
- Conditions
- Diabetic Nephropathy Type 2 - Uncontrolled, Diabetes Mellitus, Type 2, Chronic Kidney Diseases
- Trial name
- NCT05692388
- Testing
- Patient and Community Stakeholder Interviews, Cross-sectional Study Participants, Focus Groups and Intervention Mapping
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Medical College of Wisconsin
Chronic Kidney Disease
Optimizing Albuminuria Treatment in CKD With Finerenone and Semaglutide
The FINESSE-CKD trial investigates a personalized approach to the treatment of chronic kidney disease (CKD) by comparing the effects of finerenone and semaglutide on albuminuria.
- Trial name
- FINESSE-CKD (NCT07819227)
- Testing
- Finerenone (BAY 94-8862), Semaglutide 14 MG [Rybelsus], Finerenone and Semaglutide
- Where
- 6 sites in Denmark, Italy and 2 more
- Volunteers
- 41 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Diseases, Cognitive Decline
Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
The proposed research is clinical study evaluating the therapeutic benefits of curcumin on vascular function in patients with chronic kidney disease (CKD).
- Trial name
- NCT03223883
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Diana Jalal
Kidney Diseases, End-Stage Kidney Disease
Major Outcomes With Personalized Dialysate TEMPerature
People with failed kidneys need an artificial kidney machine (called dialysis) to remove toxins and extra fluid from the body. Most patients receive dialysis treatments at a hospital three times a week.
- Conditions
- Kidney Diseases, End-Stage Kidney Disease, Hemodialysis
- Trial name
- MyTEMP (NCT02628366)
- Testing
- Personalized Dialysate Temperature
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End-stage Chronic Kidney Failure
Potential Biomarkers of the Severity of Endothelial Damage in End-stage Chronic Kidney Failure
The principal objective of this study is to qualify markers of oxidative stress in inflammatory cells (monocytes) in patients with stage 3 kidney failure (diabetic or not), and patients with end-stage kidney failure (diabetic or…
- Trial name
- DIALYSOX (NCT02857556)
- Testing
- Blood sample, Retinal photography:, dialyse
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pre-Dialysis
Fixed Dose NESP Study in Subjects With CRI
Multicenter, open-label, single-arm, fixed dose study of darbepoetin alfa in subjects with Chronic Renal Insufficiency (CRI). Subjects will be screened for 2 weeks during which time blood will be drawn and vital signs will be…
- Trial name
- NCT00526929
- Testing
- darbepoetin alfa
- Volunteers
- 75 people
- Sponsor
- Amgen
Renal Impairment
Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis
The primary objective was to evaluate the incidence of clinically significant hypocalcemia following multiple 120 mg subcutaneous doses of denosumab in patients with severe chronic kidney disease (CKD) and CKD on dialysis
- Trial name
- NCT01464931
- Testing
- Denosumab
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Amgen
End Stage Renal Disease, Decision Aid
A Guide to Conservative Care
This is a randomized pilot study to test the feasibility and acceptability of a patient decision aid on conservative care among older patients with advanced CKD and their close persons.
- Conditions
- End Stage Renal Disease, Decision Aid, Patient Engagement, Dialysis
- Trial name
- NCT04919941
- Testing
- A Guide to Conservative Care
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hemodialysis, Probiotics
Effect of Probiotic and Synbiotic Administration on Nutritional Status in Hemodialysis Patients
This study aims to investigate the impact of probiotics and synbiotics on the nutritional status of patients with end-stage kidney disease (ESRD) who are undergoing hemodialysis.
- Conditions
- Hemodialysis, Probiotics, Synbiotics, Nutritional Status
- Trial name
- ProSyn-HD (NCT06891105)
- Testing
- Lactogemikan (Probiotic Supplement), Lactogemikan + Prebiotic Fiber (Synbiotic Supplement)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Renal Insufficiency, Chronic
TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)
The purpose of this study is to determine the recommended dose of the sustained-release form of BPS (TRK-100STP low dose or high dose) in Japanese patients with CRF (Primary glomerular disease/nephrosclerosis).
- Trial name
- NCT02480751
- Testing
- Beraprost
- Volunteers
- 113 people
- Sponsor
- Toray Industries, Inc
End Stage Renal Disease, AV Fistula
Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD
A prospective single-arm well-controlled study to evaluate the safety and effectiveness of a less invasive means of establishing vascular access to facilitate dialysis in patients with end stage renal disease.
- Conditions
- End Stage Renal Disease, AV Fistula, Fistula, End Stage Kidney Disease
- Trial name
- NCT02363972
- Testing
- Ellipsys Vascular Access Catheter
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- Medtronic Endovascular
Chronic Kidney Diseases, Hypertension
Chronic Kidney Disease Clinical Decision Support
To prevent serious chronic kidney disease (CKD) complications such as end-stage renal disease and cardiovascular events, better strategies are needed to identify, treat, and refer CKD patients seen in primary care clinics.
- Conditions
- Chronic Kidney Diseases, Hypertension, Diabetes
- Trial name
- CKD-CDS (NCT03890588)
- Testing
- CKD enhanced clinical decision support
- Where
- United States
- Volunteers
- 6,295 people
- Sponsor
- HealthPartners Institute
ESRD, Social Behavior
SOCIABLE Seniors Optimizing Community Integration to Advance Better Living With ESRD
This research is being done to find out the best ways to help people with end stage kidney disease take care of their daily lives and improve their social functioning.
- Conditions
- ESRD, Social Behavior, Physical Disability
- Trial name
- SOCIABLE (NCT03055273)
- Testing
- SOCIABLE
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Chronic Renal Failure, Kidney Transplantation
Fluid Intake in Kidney Failure
Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation.
- Trial name
- NCT00842322
- Testing
- high fluid intake, normal fluid intake
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Vienna
Chronic Kidney Disease, Iron-deficiency Anemia
A Clinical Trial of Oral Versus IV Iron in Patients With Chronic Kidney Disease
The long-term goal is to assess the fall in kidney function measured by glomerular filtration rate (GFR) when patients with chronic kidney disease (CKD) are exposed to intravenous iron (IVIR).
- Trial name
- NCT00830037
- Testing
- IV Iron, Ferrous Sulfate
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Indiana University
ESRD, T-Cell Dysfunction
T Cell Dysfunction in ESRD
Patients with end-stage renal disease (ESRD) suffer from high morbidity and mortality of cardiovascular and infectious disease and increased risk of all-cause mortality which is mainly attributed to the disturbed immune response.
- Trial name
- NCT04658069
- Testing
- no specific interventions
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Chronic Kidney Diseases
Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes
Patient with complex comorbidities present a growing challenge for health-care providers, that the current system is poorly designed to handle.
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Cardiovascular Diseases, Chronic Disease
- Trial name
- CareHND (NCT03362983)
- Testing
- CareHND
- Where
- Sweden
- Volunteers
- 131 people
- Sponsor
- Danderyd Hospital
Anemia, Renal Diseases
PROCRIT Extended Dosing For Maintenance of Hemoglobin in Pre-Dialysis CKD Patients
The purpose of this study is to demonstrate that once every-2-weeks and once every-4-weeks treatment with epoetin alfa, a drug that increases red blood cell production, in patients with anemia associated with chronic kidney…
- Trial name
- NCT00440466
- Testing
- epoetin alfa
- Where
- 66 sites in United States
- Volunteers
- 430 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Kidney Injury, Kidney Disease, Chronic
Early Diagnosis of Kidney Damage Associated With Tobacco Use
Tobacco consumption is associated with the appearance of several pathologies, the best known are Chronic Obstructive Pulmonary Disease, several types of cancer and cardiovascular diseases.
- Conditions
- Kidney Injury, Kidney Disease, Chronic, Tobacco Toxicity
- Trial name
- NCT03850756
- Testing
- Early kidney damage biomarkers, Predisposition to kidney injury biomarkers, Tobacco consumption
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
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