Clinical trials: Kidney Functional
Diabetic Kidney Disease
Study to Evaluate the Pharmacokinetics of Selonsertib in Participants With Normal and Impaired Hepatic Function
The primary objective of this study is to evaluate the pharmacokinetics (PK) of selonsertib in participants with impaired hepatic function relative to matched, healthy controls.
- Trial name
- NCT02509624
- Testing
- Selonsertib
- Where
- 5 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Advanced Malignancies
To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Renal Function and Renal Impairment.
The purpose of the study is to evaluate the pharmacokinetics and safety of parsaclisib in participants With normal renal function and participants with renal impairment.
- Trial name
- NCT04831996
- Testing
- parsaclisib
- Where
- 4 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Urolithiasis, Intrarenal Pressure
Renal Structural and Functional Alterations Following Repeated Ureteroscopic Procedures: An Exploratory Multimodal Imaging Study
Introduction and objectives Saline irrigation and instrumentation during Retrograde Intrarenal Surgery (RIRS) causes elevation of intrarenal pressure (IRP) inducing intrarenal backflow (IRB).
- Conditions
- Urolithiasis, Intrarenal Pressure, MRI Scans, Scintigraphy Quantification
- Trial name
- BackFlow2 (NCT07913178)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Region of Southern Denmark
Living Donor of Kidney
Assessment of Differential Renal Function by CT in Living Donors
The purpose of this study is to assess the degree of agreement of the measurement of differential renal function in living donors by CT (computed tomography) and SPECT (single photon emission computed tomography).
- Trial name
- DOVISCAN (NCT02820376)
- Testing
- Differential renal function assessment by 4D CT
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Renal Transplant Failure and Rejection, Hypotension
HOW DOES HEMODYNAMIC REGULATION AFFECTS GRAFT FUNCTIONS DURING RENAL TRANSPLANTATION?
The aim of the researchers was to evaluate the adequacy of graft function in the postoperative period of patients who underwent renal transplantation and encountered hypotension in the intraoperative period.
- Trial name
- NCT05753475
- Testing
- renal transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Diabetic Neuropathic Pain, Renal Impairment
A Study to Learn How the Study Treatment BAY2395840 Moves Into, Through and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Moderate Reduced Kidney Function and in Healthy Male and Female Participants With Normal Kidney Function
Researchers are looking for a better way to treat people who have inflammatory conditions. Inflammatory conditions may result from an increased activation of the body's natural defenses (the immune system) and are characterized…
- Conditions
- Diabetic Neuropathic Pain, Renal Impairment, Healthy Volunteers
- Trial name
- NCT05406219
- Testing
- BAY2395840
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bayer
Kidney Diseases
Detecting Markers of Kidney Function With Intravenous Microdialysis
Patients will be invited to participate from an outpatient nephrology clinic at Hammersmith Hospital. They will have a microdialysis catheter inserted into a peripheral vein and connected to a sampling system.
- Trial name
- NCT03159806
- Testing
- Microdialysis sampling
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Accunea Ltd.
Cardiovascular Disease
A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants
The purpose of this study is to measure how much of the study drug, evacetrapib, enters the blood stream and how long it takes the body to dispose of the study drug when given to participants with severe renal (kidney) impairment…
- Trial name
- NCT01825889
- Testing
- Evacetrapib
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Overweight, Obese
A Pharmacokinetic Study of HDM1005 Injection in Participants With Impaired Renal Function and Healthy Participants
The purpose of this study is to evaluate the pharmacokinetic profile and safety of a single subcutaneous injection of HDM1005 solution in participants with impaired kidney function compared to healthy participants.
- Trial name
- NCT07559240
- Testing
- HDM1005
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Pharmacokinetics, Hepatic Insufficiency
Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)
Evaluate the potential effect of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of BAY 1841788 (ODM-201).
- Conditions
- Pharmacokinetics, Hepatic Insufficiency, Renal Insufficiency
- Trial name
- NCT02894385
- Testing
- BAY1841788
- Where
- 2 sites in Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
Effect of Azimilide Dihydrochloride on Renal Function
This study will assess the effect of multiple dosing of 125 mg azimilide on glomerular filtration rate (GFR) and total creatinine clearance (GFR + active secretion) in healthy subjects.
- Trial name
- NCT00318838
- Testing
- Azimilide dihydrochloride
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Chronic Kidney Disease Patients
Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).
- Trial name
- GlikoOxEND (NCT07437729)
- Where
- Croatia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Kidney Disease (CKD), Stages 3-4 Exercise Tolerance / Functional Capacity Vascular Health / Arterial Stiffness Fatigue in CKD
"Hypoxic vs. Aerobic Training in Chronic Kidney Disease
Chronic kidney disease (CKD) leads to poor exercise tolerance, vascular dysfunction, and reduced quality of life. This randomized controlled trial will compare intermittent hypoxic training (IHT) with traditional aerobic training…
- Trial name
- IHT-CKD (NCT07180875)
- Testing
- hypoventilation group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Renal Impairment
Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function
This is a Phase 1 study to assess the pharmacokinetics (PK) of IK-1001 (sodium sulfide) in healthy volunteers as well as in subjects with varying degrees of impaired renal function.
- Trial name
- NCT00879645
- Testing
- Sodium Sulfide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Renal Impairment
Pharmacokinetics in Subjects With Renal Impairment
This is an open-label, non-randomized, parallel-group, mono-center, single intravenous dose, Phase I trial to investigate the Pharmacokinetic (PK) and safety of cilengitide in subjects with different grades of renal impairment as…
- Trial name
- NCT01504165
- Testing
- cilengitide 2000mg, cilengitide 1000mg, cilengitide > 1000mg and up to 2000mg
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Renal Impairment
A Study to Evaluate the Pharmacokinetics of VI-0521 Subjects With Renal Impairment
VI-0521, a fixed dose combination of immediate-release (IR) phentermine and controlled-release (CR) topiramate, is in Phase III clinical development as a potential therapy for obesity.
- Trial name
- NCT00768404
- Testing
- Topirmate and Phentermine
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Kidney Transplantation, Multiparametric Magnetic Resonance Imaging
Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing
Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy.
- Conditions
- Kidney Transplantation, Multiparametric Magnetic Resonance Imaging, Living Donors, Renal Fibrosis
- Trial name
- MpRenal (NCT06210555)
- Testing
- Renal transplantation, Living kidney donation
- Where
- 2 sites in Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Patrick Schjelderup
Diabetes Mellitus, Type 2
A Research Study Looking Into Blood Levels of the Medicine NNC0480-0389 in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function
Novo Nordisk is developing a combination therapy with the study medicine NNC0480-0389 and an already approved medicine called "semaglutide" for the treatment of type-2 diabetes (T2D).
- Trial name
- NCT05015894
- Testing
- NNC0480-0389
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Acute Kidney Injury Due to Sepsis, Proximal Tubule Function
Endogenous Lithium Clearance in Acute Kidney Injury
Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of…
- Conditions
- Acute Kidney Injury Due to Sepsis, Proximal Tubule Function, Lithium Clearance
- Trial name
- NCT05982340
- Testing
- Lithium clearance
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Autism Spectrum Disorders
Brain Imaging Study of Adults With Autism Spectrum Disorders
This research study investigates the effects of oxytocin and vasopressin on brain activity in adults with Autism Spectrum Disorders using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT01093768
- Testing
- Oxytocin, Vasopressin
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)