Clinical trials: Kidney Functional, active
End-Stage Renal Disease, Hemodialysis Complication
The Effect of Intradialytic Exercise on Postural Abnormalities
This randomized, assessor-blinded controlled trial will evaluate the preliminary efficacy and safety of a 12-week supervised intradialytic multimodal exercise program for improving postural abnormalities in adults receiving…
- Trial name
- NCT07720401
- Testing
- Supervised Intradialytic Multimodal Exercise Program
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Pardis Specialized Wellness Institute
Fluid Responsiveness in Early Post-kidney Transplantation Period
Collapsibility Index of the Inferior Vena Cava and Kidney Transplantation
Delayed graft function following renal transplantation is common occurrence and is associated with an increased risk of acute rejection and chronic allograft nephropathy.
- Trial name
- CIVC-KT (NCT06799299)
- Testing
- No Intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Phenylketonuria
A Trial to Examine if Repinatrabit is Processed Differently in Adults With Reduced Liver or Kidney Function Compared to Adults With Normal Liver and Kidney Function
This trial is intended to understand how the body processes repinatrabit in people with moderate liver impairment and severe kidney impairment and also to compare these results with people of similar age, weight, and sex who have…
- Trial name
- NCT07713758
- Testing
- Repinatrabit
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Infectious Diseases
A Study to Learn About the Study Medicine - Zavicefta in Patients With Sepsis or Loss of Kidney Function in Japan
The purpose of this study is to learn about the safety and how effective is Zavicefta under actual clinical practice in Japan. Zavicefta is a combination of Avibactam sodium and Ceftazidime hydrate.
- Trial name
- NCT06864585
- Testing
- Avibactam sodium/Ceftazidime hydrate
- Where
- Japan
- Volunteers
- 59 people
- Sponsor
- Pfizer
Heart Failure and Impaired Kidney Function
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event.
- Trial name
- BalanceD-HF (NCT06307652)
- Where
- 852 sites in United States, Argentina and 37 more
- Volunteers
- 3,850 people
- Sponsor
- AstraZeneca
Acute Heart Failure
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF.
- Trial name
- DIUR-AHF (NCT02638142)
- Testing
- Continuous Furosemide Infusion, Intermittent Furosemide Infusion
- Where
- 4 sites in Italy
- Volunteers
- 370 people
- Sponsor
- University of Siena
Chronic Kidney Disease (Stages 4 and 5), Chronic Kidney Disease 5D
The Practicality and Utility of Measured vs Estimated GFR in adCKD
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately…
- Trial name
- NCT07450534
- Testing
- Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Manchester University NHS Foundation Trust
Delayed Graft Function, Kidney Transplantation
The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation
Delayed graft function, defined as the need for dialysis within seven days of kidney transplantation, is a common complication affecting deceased-donor kidney transplant recipients.
- Trial name
- NCT07726134
- Testing
- Furosemide, Mannitol
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Haemodialysis, Kidney Failure
Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis
When a person's kidneys are not working properly, they need a life-saving treatment called haemodialysis three times a week to filter the waste and extra fluids from the blood.
- Trial name
- COOL HD (NCT07377500)
- Testing
- Dialysis cooling
- Where
- United Kingdom
- Volunteers
- 356 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Kidney Transplant; Complications
Home-based Exercise in Renal Transplant Recipients
Although patients who have received a kidney transplant have better health than patients on dialysis, heart problems are still the commonest cause of death for kidney transplant recipients.
- Trial name
- ECSERT (NCT04123951)
- Testing
- Home-based Exercise
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Leicester
Kidney Transplant; Complications, Vascular Diseases
Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients
Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the…
- Conditions
- Kidney Transplant; Complications, Vascular Diseases, Diabetes
- Trial name
- NCT06140537
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Diabetic Kidney Disease
Effect of Chinese Herbal Medicine on Renal Function in Diabetic Kidney Disease
This study is a randomized controlled pilot trial designed to evaluate the effects and safety of a traditional Chinese medicine formula (DKD-1) as an add-on therapy to standard treatment in patients with Diabetic Kidney Disease…
- Trial name
- NCT07657351
- Testing
- Chinese herbal formula DKD-1
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- China Medical University Hospital
Nephrotic Syndrome
Super Chinese Nephrotic Syndrome Registration System (SUCCESS)
The investigators are registering all nephrotic syndrome (NS) patients regardless of the primary causes and developing a NS database in China.
- Trial name
- NCT03001934
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
Anesthesia, Spinal Aneshtesia
Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests
Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes…
- Conditions
- Anesthesia, Spinal Aneshtesia, Acute Kidney Failure, Spinal Anesthesia Induced Hypotension
- Trial name
- NCT07015359
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Nihan Aydin Guzey
Renal Transplant, DGF
Does Early Postoperative Fluid Management Affect Functional Delayed Graft Function After Living Donor Kidney Transplantation?
Fluid management in renal transplantation is of critical importance for optimizing graft function and minimizing complications such as delayed graft function (DGF) and acute kidney injury (AKI).
- Trial name
- NCT07392996
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Ankara University
Kidney Transplantation
Ex Vivo Normothermic Perfusion in Kidney Transplantation.
A multicenter, prospective and open-label clinical investigation to evaluate the viability, performance and safety of ex vivo normothermic perfusion in kidney transplantation from DCD and DBD donors.
- Trial name
- KidneyARK (NCT05175885)
- Testing
- Ex vivo normothermic perfusion, Cold preservation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Ebers Medical Technology, S.L.
Ureteropelvic Junction Obstruction, Renal Functional Recovery
Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO
Ureteropelvic junction obstruction is an important cause of hydronephrosis and potentially reversible renal functional impairment in children.
- Trial name
- UPJO-SWE (NCT07624019)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Renal Cell Cancer
The Value of a Convolutional Neural Network-Based Renal Artery Perfusion Model in Predicting Renal Function After Partial Nephrectomy: A Prospective Study
The goal of this observational study is to develop a CNN-based machine module to predict postoperative fractional renal function in people who are proposed to undergo partial nephrectomy.
- Trial name
- NCT06751498
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Shao Pengfei
Renal Denervation Therapy
Assessment of Early GFR, Tubular Function and Pathology Changes Early and Late After Renal denervatioN
The purpose of this clinical study is to better understand how renal denervation (RDN) affects kidney function, both shortly after and up to a year after the procedure.
- Trial name
- AEGEAN (NCT07786636)
- Testing
- blood sampling
- Volunteers
- 50 people
- Sponsor
- Rede Optimus Hospitalar SA