Clinical trials: Kidney Injury, Acute
Kidney Injury, Acute, Intensive Care Unit ICU
Acute Kidney Injury - Epidemiology in Intensive Care Unit Patients 2: an International Multicenter Cohort Study
The goal of this observational study is to learn the epidemiology and outcomes of acute kidney injury in critically ill adult patients admited to the intensive care unit (ICU).
- Trial name
- AKI-EPI2 (NCT07207031)
- Where
- Belgium
- Volunteers
- 10,642 people
- Sponsor
- University Hospital, Ghent
AKI (Acute Kidney Injury) Due to Trauma
Single-Center Prospective Study to Investigate the Difference in the Incidence of Contrast-Induced Nephropathy in High-Risk Patients With the Use of the Dye-Vert Plus System
Coronary angiography (CAG) for diagnostic or therapeutic purposes such as percutaneous coronary intervention (PCI) is one of the common procedures which require the use of intravenous contrast media.
- Trial name
- Dye-Vert Plus (NCT04279457)
- Testing
- DyeVert Plus System, Standardized hydration protocol
- Where
- United States
- Volunteers
- 1,802 people
- Sponsor
- CAMC Health System
Kidney Cancer
Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal Tumors
The goal of this clinical trial is to learn if ursodeoxycholic acid, also called UDCA, can help protect kidney function in adults undergoing partial nephrectomy for kidney tumors.
- Trial name
- PURIFY (NCT07672860)
- Testing
- UDCA (Ursodeoxycholic acid)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Jinling Hospital, China
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
Critical Illness, COVID-19 Pneumonia
Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
The aim of this study is to evaluate the rate and outcomes of COVID-19 associated acute kidney injury (AKI) and use of kidney replacement therapy (KRT) in critically ill COVID-19 patients in ICUs in several large hospitals in…
- Conditions
- Critical Illness, COVID-19 Pneumonia, Acute Kidney Injury
- Trial name
- COVID-AKI-B (NCT04997915)
- Testing
- Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
- Where
- 9 sites in Belgium
- Volunteers
- 1,286 people
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
A Sample Collection Study to Validate the NEPHROCLEAR™ CCL14 Test
The objective of this sample collection study is to collect urine samples to validate the NEPHROCLEAR™ CCL14 Test in patients with KDIGO stage 2 or 3 AKI.
- Trial name
- NCT04785391
- Testing
- Urine collection for NEPHROCLEAR CCL14 Test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Astute Medical, Inc.
Acute Kidney Injury
Acute Kidney Injury After Cardiac Arrest
The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.
- Trial name
- NCT06544538
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Pharmacokinetics, Metabolites
Levosimendans Pharmacokinetics in Intensive Care Patients. An Observational Study.
Evaluation of the pharmacokinetics of levosimendan and its metabolites in intensive care patients with normal, reduced and dialysis supported renal function.
- Conditions
- Pharmacokinetics, Metabolites, Intensive Care, Renal Failure
- Trial name
- LEFKIP (NCT05076864)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
AKI - Acute Kidney Injury
The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients
With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU).
- Trial name
- NCT07624721
- Where
- Belgium
- Volunteers
- 1,416 people
- Sponsor
- University Hospital, Ghent
Septic Shock, Acute Kidney Injury
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Intensive care unit (ICU) mortality in patients with septic shock and acute kidney injury (AKI) requiring continuous…
- Trial name
- HEMOX-HDF (NCT04997421)
- Testing
- Combined HA380 hemoadsorption and continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes, Continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Acute Renal Injury
Acute Renal Injury After Major Elective Non-Cardiac Surgery
The study is planned to be a single-center study and includes patients who underwent major surgery within Istanbul University Istanbul Faculty of Medicine with an invasive arterial line.
- Trial name
- NCT04600271
- Testing
- Crystalloid Solutions, Colloid Blood Volume Expanders, blood replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 425 people
- Sponsor
- Istanbul University
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Impact of SGLT2-inhibitors on PC-AKI in ACS Patients Receiving Invasive Strategy
SGLT2-inhibitors on PC-AKI
Percutaneous coronary intervention (PCI) is one of the most common invasive strategies employed in the diagnosis and treatment of coronary artery disease (CAD) patients.
- Trial name
- NCT06491953
- Testing
- SGLT-2 inhibitors
- Where
- China
- Volunteers
- 3,600 people
- Sponsor
- Shenyang Northern Hospital
Cardiac Surgery
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.
To date, no pharmacological agents are proven efficacious in treating perioperative AKI. There is a strong biological rationale for the administration of amino acid in the management of patients at risk of AKI with increases in…
- Trial name
- PROTection (NCT03709264)
- Testing
- Amino Acids
- Where
- 22 sites in Croatia, Italy and 1 more
- Volunteers
- 3,511 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury
A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Cardiac Surgery
This study will evaluate the safety and efficacy of ABT-719 in preventing acute kidney injury in patients undergoing high risk cardiac surgery.
- Trial name
- NCT01777165
- Testing
- ABT-719
- Where
- 41 sites in United States, Denmark
- Volunteers
- 240 people
- Sponsor
- AbbVie
Patients Undergoing Valvular Heart Surgery
Relationship Between Postoperative Tempeartive and Acute Kidney Injury
The investigators aimed to identify body temperature trajectory classes based on core temperature changes during the first 12 hours post-surgery and to explore their relationship with postoperative acute kidney injury in patients…
- Trial name
- NCT06647771
- Where
- South Korea
- Volunteers
- 3,274 people
- Sponsor
- Yonsei University
Critical Illness, Acute Kidney Injury
Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT03807414
- Testing
- oXiris
- Where
- 12 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Careggi Hospital
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University
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