Clinical trials: Kidney Insufficiency
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Proteinuria
Safety and Pharmacokinetic Study of Subcutaneous ALXN1720 in Participants With Proteinuria
The primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (PK) of a single dose of ALXN1720 in participants with proteinuria.
- Trial name
- NCT05314231
- Testing
- ALXN1720
- Where
- 2 sites in South Korea
- Volunteers
- 13 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Kidney Injury
Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in Cirrhosis
The aim of this study is to evaluate: The diagnostic performance of Fractional Excretion of Urea (FEUrea) for the differential diagnosis of acute kidney injury in patients with cirrhosis and ascites presenting to a tertiary care…
- Trial name
- NCT04986137
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Acute Kidney Injury
Study of the Relaxin Agonist R2R01 in Patients at High Risk for Cardiac Surgery Associated- Acute Kidney Injury
This is a Phase 2, dose-ranging, double-blind, double-dummy, placebo-controlled, randomized study preceded by an open label safety run-in, in patients at high risk for Cardiac Surgery Associated - Acute Kidney Injury (CSA-AKI)…
- Trial name
- CSA-AKI (NCT07625553)
- Testing
- R2R01
- Where
- Italy
- Volunteers
- 430 people
- Sponsor
- River 2 Renal Corp.
Acute Kidney Injury
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing…
- Trial name
- MGHK23 (NCT02836899)
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Renal Failure Chronic Requiring Hemodialysis
Continuous Soluble Ferric Pyrophosphate (SFP) Iron Delivery Via Dialysate in Hemodialysis Patients
The purpose of this study is to confirm the safety and efficacy of Soluble Ferric Pyrophosphate (SFP) dialysate solution in maintaining iron delivery for erythropoiesis in anemic adult patients with chronic kidney disease (CKD)…
- Trial name
- CRUISE 1 (NCT01320202)
- Testing
- Soluble Ferric Pyrophosphate (SFP), Standard dialysate
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 305 people
- Sponsor
- Rockwell Medical Technologies, Inc.
End Stage Renal Disease, End-Stage Kidney Disease
Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision
The goal of this pilot randomized trial is to learn about shared decision making in kidney transplant candidates. The aim of this proposal is to evaluate the Donor Plan Donor Choice tool to promote high-quality Shared Decision…
- Conditions
- End Stage Renal Disease, End-Stage Kidney Disease, Kidney Transplantation, Esrd
- Trial name
- NCT05879302
- Testing
- Kidney Offer Shared Decision Making
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hennepin Healthcare Research Institute
End Stage Renal Disease, Renal Impairment
A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide
The primary objective of the study is to estimate the PK parameters of ribupatide in participants with severe renal impairment or end-stage kidney disease (ESKD) after a single dose of ribupatide subcutaneous (SC) injection…
- Conditions
- End Stage Renal Disease, Renal Impairment, Obesity, Overweight
- Trial name
- NCT07793929
- Testing
- Ribupatide
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kailera
Renal Failure, End Stage
The ONE Study M Reg Trial
To collect evidence of the safety of administering donor-derived regulatory macrophage (M reg) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed at…
- Trial name
- ONEmreg12 (NCT02085629)
- Testing
- Donor M reg (Mreg_UKR)
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University of Regensburg
Acute Kidney Injury, Pneumonectomy
Prognostic Significance of Preoperative Nutritional Status on Postoperative Acute Kidney Injury
The incidence of postoperative acute kidney injury (AKI) is high in patients undergoing lung resection surgery, especially in the elderly.
- Trial name
- NCT06496802
- Testing
- no intervention
- Volunteers
- 1,880 people
- Sponsor
- Wanmin Liao
Renal Failure, Renal Transplantation
A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines.
- Conditions
- Renal Failure, Renal Transplantation, Living Donors
- Trial name
- NCT01009229
- Testing
- Low and high salt diets
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock, Delirium
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.
- Conditions
- Septic Shock, Delirium, Renal Failure
- Trial name
- NCT01836302
- Testing
- Observation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Renal Insufficiency, Chronic
Living With Chronic Kidney Disease Without Renal Replacement Therapy: Experience of Women of Childbearing Age
Chronic kidney disease (CKD) affects approximately 13% of the global population. This condition is often associated with comorbidities such as diabetes and hypertension.
- Trial name
- IMAJE (NCT07690202)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Chronic Kidney Diseases
Aerobic Exercise in Patients With CKD
Patients with chronic kidney disease (CKD), especially those who are on dialysis, have a high prevalence of cardiovascular mortality and among the risk factors; inflammation and oxidative stress stand out.
- Trial name
- NCT04375553
- Testing
- Aerobic exercise
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal Fluminense
Red-Cell Aplasia, Pure
A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant Erythropoietins
The purpose of this study is to record the number of participants with chronic renal disease who are receiving treatment with epoetin alfa or other recombinant erythropoietins who develop pure red cell aplasia (PRCA, a rare form…
- Trial name
- NCT00211029
- Volunteers
- 4,670 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
End Stage Renal Disease
Blood Flow Conditions and Sounds in AVFs
This is a prospective non-pharmacological interventional study aimed at investigating the relationship between the blood flow condition and the arteriovenous fistula (AVF) sound, with the ultimate aim of predicting the AVF…
- Trial name
- APOLLO (NCT06411353)
- Testing
- MRI acquisition, US examination
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Diabetic Kidney Disease, Diabetic Nephropathies
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03840343
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Pyelonephritis, Prognostic
Factors and Prognosis of Obstructive Pyelonephritis Patients
Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit.
- Trial name
- PYELO-OBS (NCT06299215)
- Where
- France
- Volunteers
- 575 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Nafamostat Efficacy and Safety in Critically Ill Patients(NICE)
Acute kidney injury (AKI) is a common and serious problem in critically ill patients, and is known to be an independent risk factor for mortality.
- Trial name
- NCT01486485
- Testing
- heparinized saline priming group, nafamostat infusion after heparinized saline priming
- Where
- 4 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Systemic Sclerosis and Systemic Lupus Erythematous
Renal Assessment for Early Detection of Renal Impairment in Systemic Sclerosis and Systemic Lupus Erythematosus Patients
Evaluate renal resistive index in SSc and SLE patients for early detection of renal impairment. Evaluate renal multi-parametric MRI in SSc and SLE patients for early detection of renal impairment.
- Trial name
- NCT06287125
- Testing
- Renal multi-parametric MRI, Renal doppler ultrasound, Serum CD147
- Volunteers
- 95 people
- Sponsor
- Assiut University
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