Clinical trials: Kidney Pancreas Transplant
Diabetes Mellitus
Use of Campath for Induction and Maintenance Therapy in Pancreas After Kidney Transplantation
This is a single center, prospective, open-label, randomized trial at the University of Minnesota Medical Center,Fairview. Primary objectives are to determine if rejection episodes and loss rates, graft survival, level of renal…
- Trial name
- NCT00177138
- Testing
- Tacrolimus, Alemtuzumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Simultaneous Pancreas-Kidney Transplantation
To Explore the Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function After Simultaneous Pancreas-kidney Transplantation
Pancreatic kidney joint transplantation (SPK) has become the standard treatment for patients with diabetes complicated by end-stage renal disease.
- Trial name
- NCT07001917
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Pancreas Transplantation, Kidney Transplantation
A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids
Experience with tacrolimus in pancreas transplantation has become a standard for immunosuppression in almost all pancreas centers over the world.
- Trial name
- NCT00693446
- Testing
- Sirolimus, Tacrolimus
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Nantes University Hospital
Kidney Transplant Failure and Rejection
Using the Speckle Doppler to Quantify Blood Flow in Kidney and Pancreas Grafts
Kidney and Pancreas transplantation is considered the treatment of choice for many people with End Stage Renal Disease and Type 1 diabetes because quality of life and survival is often better after transplantation.
- Trial name
- NCT04202237
- Testing
- Speckle Doppler imaging, Blood sample
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Manchester University NHS Foundation Trust
Renal Transplant, Kidney Pancreas Transplant
Advagraf/Prograf Conversion Trial
Renal and kidney pancreas transplant patients will be randomized to once daily Advagraf or twice daily Prograf to assess changes in tacrolimus and mycophenolate mofetil exposure, renal allograft function, other relevant…
- Trial name
- SG#153 (NCT01410162)
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Norman Muirhead
Pancreas-Kidney Transplantation
Simultaneous Pancreas-kidney Transplantation With Campath Protocol
The purpose of this study is to determine and compare the efficacy of Campath-1H/Tacrolimus versus ATG/Tacrolimus/MMF therapy in conjunction with initial short-term steroids in Type 1-diabetic patients undergoing simultaneous…
- Trial name
- NCT00316810
- Testing
- Alemtuzumab, Rabbit Anti-Human Thymocyte Globulin
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Dr. Claudia Bösmüller
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Organ Transplantation
A Facilitated Access Program to Provide Everolimus (RAD) Maintenance for Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
Facilitated access to everolimus until it is commercially available and reimbursable by appropriate parties
- Trial name
- NCT00149981
- Testing
- everolimus (RAD)
- Where
- 153 sites in United States, Australia and 17 more
- Sponsor
- Novartis Pharmaceuticals
Kidney-Pancreas Transplantation
Prograf-Advagraf Cross Over Conversion Study
The present study is aimed at evaluating the impact of a switch from Prograf to Advagraf on renal function, trough tacrolimus levels, drug-related adverse effects and adherence in stable recipients of kidney-pancreas transplants.
- Trial name
- NCT01797341
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Kidney Failure
Screening for Patients Needing Kidney, Kidney-Pancreas, or Islet-Cell Transplant
Kidney transplantation is the preferred treatment for most end-stage kidney disease. This procedure is limited, however, by two major factors: 1) a shortage of donor organs and 2) organ rejection by the recipient.
- Trial name
- NCT00001859
- Where
- United States
- Volunteers
- 621 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cytomegalovirus
The Impact of Cytogam® on Time to Viral Load Reduction in Kidney or Kidney/Pancreas Transplant Recipients With Clinical CMV Disease
This pilot study is to assess whether using CytoGam® in combination with ganciclovir is more effective in reducing the CMV viral load over time, as compared to standard treatment with IV ganciclovir only.
- Trial name
- NCT00214240
- Testing
- CMV Immune globulin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wisconsin, Madison
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
Kidney Pancreas Transplantation
CIRTEN-Simultaneous Pancreas-Kidney Transplant Recipients
This is a Phase II/III, Single-center, Prospective, Open-label, Single Arm Study of 20 Simultaneous Kidney Pancreas recipients who received a transplant at least 3 months, but no more than 5 years prior, with a history of tremors…
- Trial name
- NCT03769298
- Testing
- Envarsus XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Transplant Complication, Diabetic Nephropathy
Enhanced Recovery After Surgery for SPK Transplantation Recipients
108 patients underwent elective SPK surgery were randomly divided into ERAS group (E) and routine care group (T). The ERAS group was consisted of evidenced-based systematic optimization approaches, while the control group…
- Conditions
- Transplant Complication, Diabetic Nephropathy, Perioperative/Postoperative Complications
- Trial name
- NCT06095544
- Testing
- Enhanced recovery for SPK recipients
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Adipose Tissue Function After Pancreas Transplantation
Clinical measures of adipose tissue mass (BMI, waist circumference, waist-to-hip ratio) do not adequately explain the inter-individual and ethnic heterogeneity in diabetes. .
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, End Stage Renal Disease
- Trial name
- NCT01729130
- Testing
- Adipose tissue biopsy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Disease Due to BK Polyomavirus, Transplantation Infection
Induction Related BK Viremia in Renal Transplant Patients
The increase immunosuppression in our transplant population has led to an unacceptable rate of patients at risk for BK virus nephropathy.
- Conditions
- Disease Due to BK Polyomavirus, Transplantation Infection, Disorder Related to Transplantation
- Trial name
- BK (NCT00610961)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Kidney Disease, Liver Disease
Remote Ischemic Preconditioning In Abdominal Organ Transplantation
Does remote ischemic preconditioning (RIPC) induced by a brief period of occlusion of blood flow to the lower extremity prior to organ recovery in deceased donors, improve short and long term outcomes after transplantation of…
- Conditions
- Kidney Disease, Liver Disease, Pancreas Disease
- Trial name
- RIPCOT (NCT00975702)
- Testing
- RIPC by Inflation of Pneumatic Tourniquet
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Nephrotoxicity
Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients
Kidney damage is a major complication of current antirejection medicines used in transplantation. An increasing number of brittle diabetics are successfully receiving a pancreas transplant.
- Trial name
- NCT02103855
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University
Pancreas Transplantation, Kidney Transplantation
Gastrointestinal and Health-related Quality of Life Outcomes in Patients With Simultaneous Pancreas-Kidney Transplants
Treatment with the immunosuppressive drug mycophenolate mofetil (MMF) may result in gastrointestinal (GI) complications in some patients.
- Trial name
- NCT00267150
- Testing
- Enteric-coated mycophenolate sodium (EC-MPS)
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals