Clinical trials: Kidney Replacement Therapy
Acute Kidney Injury, ICU Patients
Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy
The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the…
- Conditions
- Acute Kidney Injury, ICU Patients, Continuous Renal Replacement Therapy (CRRT), Electrolytes
- Trial name
- CRRT (NCT07514650)
- Testing
- continuous renal replacement therapy
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
AKI - Acute Kidney Injury, Acute Renal Failure
A Post-Market Clinical Performance and Safety Evaluation of GamCath HighFlow Dolphin Protect Catheter
The goal of this retrospective chart review is to obtain clinical safety and performance data for the GamCath HighFlow Dolphin Protect Catheter in patients with acute kidney injury, acute renal failure, or chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Acute Renal Failure, CKD, ESRD
- Trial name
- NCT05888376
- Testing
- Vascular access catheter to support dialysis or CRRT
- Where
- 2 sites in Poland
- Volunteers
- 76 people
- Sponsor
- Vantive Health LLC
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Kidney Failure
Hannover Dialysis Outcome Study
Mortality rates of patients with acute kidney injury in the intensive care unit have changed little over the past few decades despite significant advances in supportive care.
- Trial name
- HAND-OUT (NCT00529139)
- Testing
- Standard extended dialysis, Intensified extended dialysis
- Where
- Germany
- Volunteers
- 157 people
- Sponsor
- Hannover Medical School
Continuous Renal Replacement Therapy (CRRT), End Stage Kidney Disease (ESRD)
Prospective Analysis of Arteriovenous Access (AVA) Use in Continuous Renal Replacement Therapy: A Feasibility Project
This study will test whether patients who already have a permanent dialysis access (an arteriovenous fistula or graft) can safely use that access for continuous dialysis (CRRT) while they are critically ill in the intensive care…
- Trial name
- CRRT (NCT07447128)
- Testing
- Cannulation of permanent dialysis access, for the purpose of delivering continuous renal replacement therapy.
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- East Carolina University
Sepsis, Amino Acid Catabolism Disorder
Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)
Sepsis is a life-threatening condition associated with high morbidity and mortality. The breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (FAAs).
- Trial name
- NCT05739604
- Testing
- Blood sample analysis
- Where
- Poland
- Volunteers
- 26 people
- Sponsor
- Medical University of Gdansk
Need for Renal Replacement Therapy and Anti-infective Therapy Due to Severe Infection
Drugmonitoring of Antiinfective Drugs in Patients Receiving Continous Veno-venous Hemodiafiltration (ABx-CVVHDF)
Approximately 300 patients have to be enrolled in the study. They are followed up until the end of ICU stay. Usually in clinical routine, patients suspected to have infection and simultaneously renal dysfunction making CVVHDF…
- Trial name
- NCT02242721
- Where
- 2 sites in Germany
- Sponsor
- Charite University, Berlin, Germany
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Kidney Injury, Kidney Replacement
Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy
A pilot randomized clinical trial comparing a protocol-based fluid management strategy to usual care in critically ill patients receiving kidney replacement therapy.
- Conditions
- Acute Kidney Injury, Kidney Replacement, Critical Illness
- Trial name
- Probe-Fluid (NCT05473143)
- Testing
- Protocol-based fluid management, Usual care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Kidney Failure
Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy
This is an observational study that evaluates the dialysis clearance and pharmacokinetics of antibiotics with different protein-bound levels in patients receiving renal replacement therapy.
- Trial name
- NCT03714789
- Testing
- Blood and spent dialysate collection
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Acute Renal Failure
Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e.
- Trial name
- CONVINT (NCT01228123)
- Testing
- RRT for acute kidney failure using the CVVH method, RRT for acute kidney failure using the IHD (intermittent HD)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- Charite University, Berlin, Germany
Beta-lactam, Continuous Renal Replacement Therapy
Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study
Pneumonia are the most frequent infections in ICU. Little is known about beta-lactam doses necessary for this infection for patients treated with continuous veino-veinous hemodialysis.
- Conditions
- Beta-lactam, Continuous Renal Replacement Therapy, Pneumonia, Antibiotic
- Trial name
- BLIPIC (NCT03897582)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier de Valenciennes
Acute Renal Failure
Fenoldopam and Ketanserin for Acute Kidney Failure Prevention After Cardiac Surgery
The purpose of the study is to compare the effect of fenoldopam and ketanserin on kidney function preservation in patients at high risk for renal failure after cardiac surgery.
- Trial name
- NCT00557219
- Testing
- fenoldopam (Corlopam), ketanserin (Sufrexal)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Gdansk
Sepsis-Associated Organ Dysfunction, RTT
CRRT Timing in Sepsis-associated AKI in ICU
Sepsis continues to be a major global cause of both mortality and morbidity. Furthermore, the development of acute kidney injury (AKI) in sepsis increases the risk of unfavorable outcomes.
- Trial name
- CRTSAKI (NCT03175328)
- Testing
- continuous renal replacement therapies
- Where
- 2 sites in China
- Volunteers
- 460 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Acute Lung Injury, Acute Kidney Injury
Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy
Objective of the study is to assess the safety and efficacy of CO2 removal by the multiECCO2R (CO2 Removal System) on the multiFiltrate/multiFiltrate Pro in veno-venous extracorporeal circulation during continuous renal…
- Conditions
- Acute Lung Injury, Acute Kidney Injury, Hypercapnia, Covid19
- Trial name
- multiECCO2R (NCT04871893)
- Testing
- multiECCO2R blood-gas exchanger
- Where
- 6 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Toxic Alcohol Poisoning
Fomepizole Dosing During Continuous Renal Replacement Therapy (CRRT)
The project is a prospective observation study of patients with suspected or confirmed toxic alcohol poisoning treated with fomepizole and continuous renal replacement therapy (CRRT)
- Trial name
- NCT04649138
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Oslo University Hospital
Continuous Renal Replacement Therapy
CRRTNet Registry- A Prospective Observational Registry
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury.
- Trial name
- CRRT (NCT02034448)
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- AKI Critical Care Research Foundation