Clinical trials: Knee
Primary Osteoarthritis of Knee Nos
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement
The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee replacement, and 2) whether…
- Trial name
- NCT01850394
- Testing
- Tranexamic Acid, Physiologic saline
- Where
- Thailand
- Volunteers
- 152 people
- Sponsor
- Mahidol University
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
The objective of this exploratory study is to evaluate the cellular and connective tissue composition of joints from patients with Osteoarthritis (OA) who have been treated with fasinumab, compared with those treated with placebo…
- Trial name
- NCT03949673
- Testing
- Fasinumab, Naproxen, Diclofenac
- Where
- 15 sites in United States, Poland and 1 more
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals
Pain
Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty
This is a Phase 4, multicenter, open-label study designed to characterize the pharmacokinetic (PK) profile of total bupivacaine in approximately 15 adult subjects undergoing primary unilateral total knee arthroplasty (TKA) with…
- Trial name
- NCT02284386
- Testing
- Bupivacaine SNB, EXPAREL Infiltration
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Total Knee Arthroplasty
interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following TKA
The purpose of this study is to determine if home-based therapy with monitoring via telemedicine can overcome many barriers to compliance and improve rehabilitation.
- Trial name
- NCT02646761
- Testing
- InterACTION, Standard of Care Physical Therapy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- James J. Irrgang
Arthroplasty, Replacement, Knee
ShapeMatch Cutting Guide Functional Outcomes Study
Randomized evaluation of the ShapeMatch Cutting Guide for primary total knee replacement (TKR) in a consecutive series of patients who meet the eligibility criteria.
- Trial name
- ShapeMatch (NCT02539992)
- Testing
- Triathlon® CR/Kinematic Alignment, Triathlon® CR/Neutral Overall Limb Alignment, Triathlon® CR/Conventional Limb Alignment
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 44 people
- Sponsor
- Stryker Orthopaedics
Knee Prosthesis, Knee Replacement Arthroplasty
Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA
Utilize previously developed mathematical model to determine in vivo knee mechanics (kinematics, forces, stresses, areas and sound) for subjects having a Sigma Posterior Stabilizing (PS) mobile bearing (MB) total knee…
- Trial name
- Sigma MB TKA (NCT01714492)
- Testing
- Sigma Posterior Stabilizing Rotating Platform TKA Beaded Poly
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis
Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study
The primary objective of this investigation is to compare the precision of long leg alignment achieved by the two types of procedure.
- Trial name
- NCT00733330
- Testing
- Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 86 people
- Sponsor
- DePuy International
Knee Arthroplasty, Total
iTotal Pilot Study of ConforMIS Custom Total Knee Implant
To compare the outcomes of patients receiving the ConforMIS custom total knee implant to the outcomes of patients who receiving an off-the-shelf total knee implant.
- Trial name
- NCT02186587
- Testing
- ConforMIS custom total knee
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Missouri-Columbia
Knee Osteoarthritis
The Effect of Osteopathic Manual Therapy on Vascular Supply
The purpose of this study is to determine if the use of osteopathic manual therapy can influence the vascular supply to the knee, knee range of motion, balance and knee pain, in a group of subjects with knee osteoarthritis.
- Trial name
- NCT01020591
- Testing
- Osteopathic evaluation, Osteopathic evaluation with treatment
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis, Knee
Study of Intra-articular Injections vs Placebo in Patients With Pain From Osteoarthritis of the Knee
The aim of this study is to evaluate the effectiveness and safety of a combined Traumeel® / Zeel® injection against placebo (saline) in patients with moderate-to-severe pain associated with osteoarthritis of the knee.
- Trial name
- MOZArT (NCT01887678)
- Testing
- Traumeel® / Zeel® Injectable Solution
- Where
- 30 sites in United States
- Volunteers
- 287 people
- Sponsor
- Biologische Heilmittel Heel GmbH
Opioid Use, Pain, Post Operative
A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Opioid addiction in post-operative patients is recognized but not fully understood; therefore, in order to address this growing crisis, it is essential to explore alternative approaches to managing pain and apply them to the…
- Trial name
- NCT05252858
- Testing
- nCAP Signal Relief Patch, Standard of Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Jacques E. Chelly
Osteoarthritis of the Knee
A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis
This study will evaluate the efficacy of three intra-articular injections, given 2 weeks apart, of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT02242435
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Osteoarthritis
Gait Modification Treatment for Knee Osteoarthritis
Knee osteoarthritis (OA) is a costly health condition affecting more than 10% of Canadian adults. Excessive and unbalanced loads passing through the knee joint have been implicated in the progression of OA.
- Trial name
- NCT02019108
- Testing
- Progressive walking program with toe-out gait modification, Progressive walking program
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- University of British Columbia
Total Knee Arthroplasty(TKA), Total Knee Replacement
Flexion Versus Extension Soft Tissue Repair in Total Knee Arthroplasty
The purpose of the present study is to determine the influence of position of soft tissue repair (flexion versus extension) in post operative range of motion(ROM) and functional outcome in patients who underwent primary total…
- Trial name
- NCT02067533
- Testing
- soft tissue repair in flexion position, soft tissue repair in extension position
- Where
- Iran
- Volunteers
- 91 people
- Sponsor
- Isfahan University of Medical Sciences
Postoperative Urinary Retention
Trial of Prophylactic Tamsulosin for Postoperative Urinary Retention in Primary Total Hip and Knee Arthroplasty Patients
The study aims to evaluate the efficacy of prophylactic tamsulosin in reducing the incidence of postoperative urinary retention in primary total knee and hip arthroplasty patients.
- Trial name
- NCT02518971
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- University of Michigan
Overuse Injury, Body Mass Index in Athletes
Hyaluronic Acid in Overuse Knee Pain
Sports activity represents part of day living people, a knee pain originated by high demand joint activity could represent a limitation to continue sports.
- Trial name
- NCT05450458
- Testing
- KNEE JOINT INFILTRATION WITH HYALURONIC ACID WITH SORBITOL SYNOLIS VA
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Regional Tlalnepantla
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteoarthritis, Knee
Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty
This study is designed to compare prospectively, in a randomized Level 1 evidence fashion, the clinical, functional, and radiographic results of a modular polished tibial (MPT) tray with a moderately cross-linked polyethylene…
- Trial name
- NCT00979147
- Testing
- TKA surgery with modular polished tibial baseplate/XLK design, TKA surgery with the nonmodular APT/GVF design, P.F.C.® Sigma Knee System
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteoarthritis
Midvastus Versus Medial Parapatellar Approach for Minimally Invasive Total Knee Arthroplasty
The purpose of this study is to compare two different surgical approaches for total knee replacement surgery. The mini-midvastus approach involves cutting less of the thigh muscle (quadriceps) tendon than the classic approach…
- Trial name
- NCT01132378
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Heekin Orthopedic Research Institute
Knee Osteoarthritis, Knee Pain Chronic
Molecular Pathways Involved in Knee Pain
Knee osteoarthritis (OA) is the most common form of arthritis and the most common cause of knee pain in the world. The rate of knee arthritis is as high as that of cardiac disease and is the most common problem in individuals…
- Trial name
- NCT04443452
- Testing
- Quantitative Sensory Testing, Radiographic Evaluation, Ultrasound-guided Aspiration
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- University of Nottingham
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