Clinical trials: Knee
Osteoarthritis, Knee, Osteoarthritis, Hip
Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
- Trial name
- NCT02197273
- Testing
- Liposomal bupivacaine, Standard of care analgesia
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- OhioHealth
Pain
Ear Acupuncture for Pain Associated With Ambulatory Arthroscopic Knee Surgery
The investigators propose to complete a randomized controlled trial to compare ear acupuncture at Cingulate gyrus, thalamus, omega 2, shen-men, and point zero on the right and left ear plus standard of care versus standard of…
- Trial name
- BFAKnee (NCT01447329)
- Testing
- Ear Acupuncture, Standard Treatment
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Knee Pain
Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty
Single-arm, single-center, no sham or placebo, prospective pilot trial designed to evaluate the safety and efficacy of transcatheter arterial embolization in patients with persistent knee pain resistant to conservative management…
- Trial name
- NCT06134817
- Testing
- Embozene Color-Advanced Microspheres.
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health
Osteoarthritis, Knee
A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.
- Trial name
- NCT05462990
- Testing
- QUC398
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 101 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis of the Knee
Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee
Patients with knee pain due to Osteoarthritis (OA) experiencing sub-optimal pain relief from their current analgesic regimen will participate in a pilot clinical trial to evaluate the effectiveness and tolerability of the…
- Trial name
- NCT00589979
- Testing
- Lidoderm (Lidocaine 5% Patch)
- Where
- 20 sites in United States
- Volunteers
- 169 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Tear of Meniscus of Knee
Clinical Application of BioCleanse Meniscus
This study will follow patients after routine surgery of a meniscal allograft transplant.
- Trial name
- Meniscus (NCT00659880)
- Testing
- BioCleanse Meniscus
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Postoperative Pain
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
This is a Phase 2b, randomized, double-blind, saline placebo- and active-controlled, multicenter study in subjects undergoing primary unilateral total knee arthroplasty (TKA) to evaluate the analgesic efficacy, safety, and…
- Trial name
- NCT03015532
- Testing
- HTX-011, Bupivicaine HCl, Ropivacaine
- Where
- 24 sites in United States
- Volunteers
- 285 people
- Sponsor
- Heron Therapeutics
Osteoarthritis, Knee, Osteoarthritis, Hip
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a…
- Trial name
- NCT03737149
- Testing
- mymobility with Apple Watch
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 6,559 people
- Sponsor
- Zimmer Biomet
Amputation, Prosthesis User
Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads
The aim of this research is to identify the prosthetic foot that results in improved walking performance when individuals with lower limb amputation carry infants, toddlers, or other loads.
- Trial name
- NCT07159490
- Testing
- Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Puget Sound Health Care System
Knee Osteoarthritis
Self Transcranial Direct Current Stimulation and Mindfulness-based Meditation for Pain in Older Adults With Knee Osteoarthritis
The purpose of this study is to determine the feasibility and preliminary efficacy of a two-week self tDCS and mindfulness-based meditation for pain in older adults with knee osteoarthritis (OA).
- Trial name
- NCT03747640
- Testing
- Self Transcranial Direct Current Stimulation (tDCS), mindfulness-based meditation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Knee Pain Chronic
Chronic Pain and Functional Prognosis After Total Knee Replacement: Continuous Locoregional Analgesia by Catheter to the Femoral Triangle Versus Tissue Infiltration as Part of an Improved Rehabilitation After Surgery Approach
The prevalence of Chronic Post-Surgical Pain (CPSP) after knee replacement, defined as pain greater than or equal to 4/10 on the visual analogue scale after the third postoperative month, is recognised as high, with an average of…
- Trial name
- TKAFTER (NCT03998813)
- Testing
- Ropivacaine
- Where
- 5 sites in France
- Volunteers
- 287 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP)
This is a multi-phase study that will develop and test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening…
- Trial name
- NCT03780400
- Testing
- Osteoarthritis Physical Activity Care Pathway
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Rheumatoid Arthritis
Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA
The study will evaluate the clinical performance of the rotating platform and fixed bearing implants through patient questionnaires, outcomes scoring and radiographic assessment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis
- Trial name
- NCT00289107
- Testing
- Total Knee Arthroplasty, Total knee replacement
- Where
- 3 sites in United States
- Volunteers
- 149 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee…
- Trial name
- ITIC (NCT00565812)
- Testing
- SD-6010
- Where
- 183 sites in United States, Argentina and 12 more
- Volunteers
- 1,457 people
- Sponsor
- Pfizer
Pain
EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty
The purpose of this study is to evaluate the safety and pharmacokinetics of EXPAREL in subjects who undergo femoral nerve block with bupivacaine HCl for unilateral total knee arthroplasty (TKA).
- Trial name
- NCT02255500
- Testing
- Bupivacaine FNB, EXPAREL Infiltration
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05449132
- Testing
- RTX-GRT7039
- Where
- 81 sites in United States, Denmark and 3 more
- Volunteers
- 466 people
- Sponsor
- Grünenthal GmbH
Chronic Pain
Pain and Function After Orthopedic Surgery
The purpose of this study is to provide preliminary data for a Program Project Grant to the National Institutes of Health to examine specific explanations regarding identifying patients at risk for chronic pain after surgery and…
- Trial name
- NCT01390298
- Testing
- Observational
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University
Knee Osteoarthritis
Steroid Injection vs. BioDRestore for Patients With Knee OA
This study will include patients who are diagnosed with knee OA and are recommended for a knee injection. Study subjects will be randomized to receive either the standard of care knee injection (steroid) or amniotic tissue…
- Trial name
- NCT02767492
- Testing
- BioD Restore, Kenalog
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Hawkins Foundation
Osteoarthritis, Knee
Evaluation of Methods of Teaching Self-management Strategies to Patients With Symptomatic Knee Osteoarthritis
Symptomatic knee osteoarthritis greatly impacts the quality of life, mobility, independence, and even safety of the individuals who suffer from it.
- Trial name
- NCT03245463
- Testing
- Educational handout, Verbal script, Hyaluronic Acid
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
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