Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)
The purpose of this study is to assess the efficacy of a 12-week low-load neuromuscular electrical stimulation with volitional contraction (NMES-VC) training program to improve quadriceps strength and activation, while not…
- Trial name
- NCT02802878
- Testing
- Hybrid Training using Electrodes and Joint Motion Sensors, Isokinetic Training with Isokinetic Dynamometer
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Kansas Medical Center
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Knee Osteoarthritis
CRx-102 Osteoarthritis Multicenter Evaluation Trial
CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone.
- Trial name
- COMET-1 (NCT00521989)
- Testing
- CRx-102 (2.7/90), Prednisolone, CRx-102 (2.7/180)
- Where
- 58 sites in United States, Canada
- Volunteers
- 279 people
- Sponsor
- Zalicus
Knee Osteoarthritis, Obesity
A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
The main purpose of the study is to evaluate the efficacy and safety of ecnoglutide injections versus placebo in obese participants with KOA.
- Trial name
- NCT07734311
- Testing
- Ecnoglutide Injection
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Knee Osteoarthritis
Psoas Sciatic Blockade for Knee Arthroplasty
Objectives: To compare the efficacy of continuous combined psoas sciatic block as a sole anaesthetic technique with conventional combined spinal epidural anesthesia for patients undergoing total knee arthroplasty.
- Trial name
- NCT03088371
- Testing
- Bupivacaine 0.25%, Pajunk Needle, Portex combined spinal epidural kit
- Volunteers
- 80 people
- Sponsor
- Menoufia University
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
Osteoarthritis
A First-in-human Study to Investigate Safety and Tolerability of SAR446959 in Participants With Osteoarthritis of the Knee
This is a randomized, placebo-controlled, participant- and Investigator-blinded Phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of ascending single intra-articular doses of SAR446959 in…
- Trial name
- NCT06704932
- Testing
- SAR446959
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Sanofi
Osteoarthritis, Knee
Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Evaluation of Safety, Tolerability, and Efficacy of XT-150, a plasmid DNA with a variant of human IL-10 transgene. XT-150 will be a single injection into the knee synovial capsule for the Treatment of Osteoarthritic Pain.
- Trial name
- NCT03477487
- Testing
- XT-150
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis
Outcomes Following Total Knee Arthroplasty
The purpose of this investigation is to determine both patient-reported and performance-based outcomes, specifically muscle function and kinematic/kinetic outcomes, between four different surgical total knee prostheses in…
- Trial name
- NCT02364011
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Utah
Knee Osteoarthritis
Study for Rural Innovations in the Delivery of Exercise
: Falls are the primary cause of injury and a leading cause of disability and mortality among older adults. Risk factors for falling are common among older adults with knee osteoarthritis (OA) - a highly prevalent condition.
- Trial name
- STRIDE (NCT04881864)
- Testing
- Tele-Enhance Fitness
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Knee Osteoarthritis
Exercise and Pain Sensitivity in Knee Osteoarthritis
A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability. While the link between exercise and reduced disability is mediated by e.g.
- Trial name
- NCT01545258
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis (Knee), Metabolic Syndrome (MetS)
Effect of Resistance Exercises on Serum IGF-1 Levels in Knee Osteoarthritis
The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis.
- Trial name
- NCT07890155
- Testing
- Resistance Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Painful Osteoarthritis of the Knee
Radiofrequency Ablation of Genicular Nerves for Advanced Osteoarthrosis of the Knee Joint 1 Year Follow-up.
Pharmacological treatment of pain due to osteoarthritis of the knee often proves to be inadequate and/or cause intolerable side effects.
- Trial name
- NCT02688543
- Testing
- RF treatment, radiofrequency ablation, ultrasound
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital General de Jerez de la Frontera
Knee Osteoarthrosis
Participants With Knee Osteoarthrosis
Title: Efficacy and Safety Trial of PRP and ICQ for Elderly Women with KOA Goal: To assess if PRP and ICQ reduce symptoms and improve mobility in elderly women with knee osteoarthritis.
- Trial name
- KOA (NCT06535425)
- Testing
- Platelet-Rich Plasma, Isometric Contractions of Quadriceps, Platelet-Rich Plasma Combined with Isometric Contractions of Quadriceps
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Chengdu Sport University
Knee Osteoarthritis
Shock Wave Versus Iontophoresis in Treatment of Subjects With Knee Osteoarthritis
Both extra corporeal shock wave and dexamethasone iontophoresisare effective in treatment of knee osteoarthritis but which one is more effective is not clear yet .
- Trial name
- Shockwave (NCT04731350)
- Testing
- radial extracorporeal shock wave, iontophoresis, Exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Osteoarthritis
Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis
A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the efficacy of a single dose of Autologous Protein Solution (APS) in patients with Osteoarthritis (OA) of the knee.
- Trial name
- PROGRESS IV (NCT02905240)
- Testing
- nSTRIDE APS, Saline
- Where
- 27 sites in United States
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee
This Phase II clinical study is to evaluate the efficacy and safety of DA-5202 in patients with osteoarthritis of the knee.
- Trial name
- NCT02554240
- Testing
- DA-5202 20mg, DA-5202 10mg, Na Hyaluronate 20mg
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Dong-A ST Co., Ltd.
Osteoarthritis
Aerobic Exercise Intervention for Knee Osteoarthritis
This trial will test if walking or bicycling exercise is effective as a non-surgical treatment option for patients with knee osteoarthritis.
- Trial name
- NCT00049816
- Testing
- Walking exercise, Cycling Exercise
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Total Knee Replacement
Knee Arthroplasty Activity Trial
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA).
- Trial name
- KArAT (NCT04107649)
- Testing
- Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives, Wrist based activity tracker wear, Basic Study Activities
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
The Knee Usual Care Evaluation Study
The purpose of this prospective data collection is to track patients who are treated at HSS who are confirmed with knee osteoarthritis.
- Trial name
- KUCE (NCT01905358)
- Where
- United States
- Volunteers
- 906 people
- Sponsor
- Hospital for Special Surgery, New York