Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Cognitive Muscular Therapy for People Awaiting Knee Joint Replacement
The primary aim will seek to understand whether Cognitive Muscular Therapy (CMT) could provide pain relief for people on a waiting list for joint replacement.
- Trial name
- NCT05801510
- Testing
- Cognitive Muscular Therapy for knee pain
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Salford
Knee Osteoarthritis, Pain
Reiki Effects on Pain, Functional Status and Holistic Well-Being in Patients With Knee Osteoarthritis
This study aimed to examine the effect of Reiki therapy on pain, functional status and holistic well-being in patients with knee osteoarthritis.
- Trial name
- NCT05665959
- Testing
- Reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara Medipol University
Gonarthrosis, Obesity
Adipose Tissue and Symptomatic Gonarthrosis
1. Prevalence of osteoarthritis in France Osteoarthritis (OA) is a very common disease, affecting almost 15% of the population. It is responsible for a significant socio-economic cost in connection with the chronic and disabling…
- Trial name
- TAGS (NCT06314191)
- Testing
- blood sampling, knee radiography
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Knee Osteoarthritis
Blood Flow Restriction Training in Individuals Awaiting Total Knee Replacement
The aim is to demonstrate that preoperative exercises (pre-habilitation) using blood-flow restriction training (BFRT) is safe, well tolerated, improves muscle function, decreases functional limitation, and increases physical…
- Trial name
- NCT06111690
- Testing
- Blood Flow Restriction Training (BFRT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Osteoarthritis, Knee
Telerehabilitation Gait Modification
Excessive knee joint loads during walking can contribute to knee osteoarthritis progression. Changing the rotation of the foot (in-toeing or out-toeing) while walking can lower knee joint loads and improve pain and function.
- Trial name
- TELEMOD (NCT04683913)
- Testing
- Foot rotation modification, Waiting Period - Delayed Group
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis
Descriptive Study of Knee Joint Pain During Strength Training After Total Knee Arthroplasty
Background: In the early phase after a total knee arthroplasty (TKA), patients experience multi-level weakness in the operated leg, which is caused primarily by reduced central nervous system (CNS) activation failure of the…
- Trial name
- NCT01729520
- Testing
- Knee extension strength training
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Osteoarthritis of the Knee
An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480)
The purpose of this study is to assess the safety and efficacy of duloxetine in participants with osteoarthritis and knee pain. The study will last for 1 year.
- Trial name
- NCT02335346
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 93 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
ROM Outcomes in Patients Undergoing a Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of patients undergoing primary TKA after photographing final knee range of motion immediately post-operatively and sharing these photographs with patients…
- Trial name
- NCT04217486
- Testing
- Patient will be shown a photograph of their knee at 2 weeks postop, Patient will not be shown a photograph of their knee at 2 weeks postop
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Arthroplasty, Replacement
Evaluate the Performance of JOURNEY II CR in TKA Populations
Background: The JOURNEY II CR Total Knee System consists of femoral component made from oxidized zirconium (OXINIUM) Purpose: Post-market evidence generation for JOURNEY II CR Total Knee System Objectives: Evaluate the…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- JIICRTKA (NCT04818840)
- Testing
- Resurfaced Patella, Un-resurfaced Patella
- Where
- 8 sites in China, India and 3 more
- Volunteers
- 62 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Analgesic Effectiveness of Three Different Doses of a New Formulation of Lamaline in a Model of Painful Knee (Gonarthrosis)
This study aims to assess the analgesic effectiveness and safety of three different doses of a new formulation of Lamaline® versus Dafalgan® Codeine after 10 days administration in subjects with painful gonarthrosis
- Trial name
- NCT00264225
- Testing
- Lamaline® , 3 different doses, Dafalgan codeine
- Where
- 171 sites in France
- Sponsor
- Solvay Pharmaceuticals
Osteoarthritis, Knee
GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs
Unicompartmental knee arthroplasty (UKA) is the principal surgical alternative to the total knee arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Trial name
- NCT03522025
- Testing
- Unicompartmental Knee Arthroplasty (UKA)
- Where
- 5 sites in France, Switzerland
- Volunteers
- 70 people
- Sponsor
- Medacta International SA
Osteoarthritis
Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients
Primary Objective To substantiate the efficacy of 2.2 g FLEXISEQ® for the treatment of pain related to osteoarthritis (OA) of the knee in patients contraindicated for or with clinical intolerance to NSAIDs.
- Trial name
- OANIT (NCT02594176)
- Testing
- FLEXISEQ®
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Pro Bono Bio
Osteoarthritis (OA), Knee Injury
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in…
- Conditions
- Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
- Trial name
- PRGFSECKOA (NCT07157891)
- Testing
- MSC-Derived Secretome, MSC-Derived Secretome + Autologous PRGF
- Volunteers
- 25 people
- Sponsor
- University of the Punjab
Osteo Arthritis Knee, Movement Disorders
Investigation of the Effect of Movement Mobilization Concept on Sensory, Pain, Muscle Activation in Patients With Knee Osteoarthritis
Individuals with knee osteoarthritis are one of the groups most affected by musculoskeletal disorders and experience pain and mobility limitations that significantly limit their daily living activities.
- Conditions
- Osteo Arthritis Knee, Movement Disorders, Physical Disability, Knee Osteoarthritis
- Trial name
- NCT06527313
- Testing
- Movement Mobilization Concept, Exercise and Tape, Special Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istinye University
Osteoarthritis, Knee Osteoarthritis
Project Osteoarthritis: Recovering Quality of Life Through Education
Osteoarthritis (OA) has a major impact on mobility, disability and loss of productivity of patients. Patients can become disabled early in life by OA.
- Trial name
- PARQVE (NCT01572051)
- Testing
- Educational Course, Phone Calls, Printed Material
- Where
- Brazil
- Volunteers
- 228 people
- Sponsor
- University of Sao Paulo General Hospital
Knee Osteoarthritis, Gonarthrosis; Primary
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Gonarthrosis; Primary, Total Knee Arthroplasty
- Trial name
- TKA (NCT07442812)
- Testing
- Routine perioperative management
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Haseki Training and Research Hospital
Knee Osteoarthritis
Efficacy of Hip Strengthening on Dynamic Knee Stability, Disability and Gait in Knee Osteoarthritis
this study will be conducted to investigate the role of hip strengthening in improving dynamic knee stability, gait parameter, lower extremity strength and disability in knee osteoarthritis
- Trial name
- NCT04509830
- Testing
- hip strengthening, quadriceps strengthening, stretch hamstring,cuff muscles
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis Thumb, Osteoarthritis, Knee
Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints
The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints.
- Conditions
- Osteoarthritis Thumb, Osteoarthritis, Knee, Metabolic Disease
- Trial name
- NCT06370312
- Testing
- Trapeziectomy
- Where
- 2 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
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