Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis
This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes.
- Trial name
- NCT07484529
- Testing
- Aquatic Mobilization with Movement, Land Mobilization with Movement
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Osteoarthritis
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)
The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem…
- Trial name
- MILES (NCT03818737)
- Testing
- Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs
- Where
- 5 sites in United States
- Volunteers
- 475 people
- Sponsor
- Emory University
Osteoarthritis, Knee
fMRI Study of Expectancy on Acupuncture Treatment Outcomes in Knee OA
The results of the proposed experiments will directly inform clinicians who treat patients with osteoarthritis of the knee about how to maximize the benefits of acupuncture treatments.
- Trial name
- KOA (NCT01040754)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee
Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis
Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression.
- Trial name
- NCT00041756
- Testing
- PG-530742, 50 mg PG-530742, 100 mg PG-530742
- Where
- 23 sites in Hungary, United Kingdom
- Volunteers
- 395 people
- Sponsor
- Procter and Gamble
Osteoarthritis Knees
Adipose-tissue-derived Total-Stromal-cells (TOST) Therapy in Knee Osteoarthritis
In this phase II Randomized Clinical Trial (RCT), impacts of a single Intra-articular injection of autologous adipose tissue derive total-stromal-cells (TOST) on knee pain, physical function, stiffness, and cartilage thickness…
- Trial name
- NCT05280002
- Testing
- Adipose Tissue derived Total-Stromal-Cells (TOST)
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Osteoarthritis
Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies
To assess the feasibility of using rhBMP-2/CPM in OWO as a surgical model for pharmacodynamic studies, with assessment of the following parameters: Injecting the desired volume of rhBMP-2/CPM within the defect Conducting…
- Trial name
- NCT00243295
- Testing
- rhBMP-2/CPM
- Volunteers
- 6 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthritis
To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee
The purpose of this study was to determine whether, in patients with mild to moderate knee osteoarthritis, canakinumab is safe and tolerable when injected intra-articularly.
- Trial name
- NCT01160822
- Testing
- Canakinumab, Naproxen
- Where
- 13 sites in United States, Finland and 2 more
- Volunteers
- 169 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee
Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty
Studies have demonstrated that early rehabilitation interventions following knee arthroplasty (TKA) can shorten the time needed to regain baseline extension/full extension and gait mechanics.
- Trial name
- NCT05678231
- Testing
- Zero Degree Knee Positioner
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Prisma Health-Midlands
Knee Osteoarthritis
Implementation of Tele-Exercise for Management of Knee Osteoarthritis in Older Rural Primary Care Patients
Knee osteoarthritis (OA) is highly prevalent and a leading cause of pain that limits physical functioning in older adults. Clinical practice guidelines recommend physical exercise for managing symptoms of knee OA.
- Trial name
- NCT04706702
- Testing
- Tele-EnhanceFitness
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Knee Osteoarthritis
Effectiveness of Two Hyaluronic Acids in Osteoarthritis of the Knee
The purpose of this study is to assess whether a single injection hyaluronic acid (HA) product is not inferior to a 3 injection HA product at 24 weeks (6 months), in terms of effectiveness in reducing pain when walking in…
- Trial name
- NCT01543737
- Testing
- 3ml hyaluronic acid (DUROLANE), 2ml hyaluronic acid, (HYALGAN)
- Where
- 17 sites in France, Monaco
- Volunteers
- 290 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Knee
Evaluation of the TruMatch® System in Knee Prosthetic Surgery
Patient specific instrumentation is an alternative to conventional intra- and extra-medullary guides to perform the femoral and tibial cuts in total knee replacement (TKR).
- Trial name
- NCT01876654
- Testing
- TruMatch® patient specific cutting guide
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- University of Milan
Osteoarthritis
Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey
Nationwide descriptive epidemiology survey aiming to determine lower limb OA prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in…
- Trial name
- 3000ARTHROSE (NCT01400529)
- Where
- 6 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Central Hospital, Nancy, France
Knee Osteoarthritis
Knee Osteoarthritis and Rehabilitation
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that causes hypertrophic changes in bone. OA is a non-inflammatory progressive musculoskeletal disease and is one of the most common degenerative…
- Trial name
- NCT06432842
- Testing
- Laser Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Karabuk University
Consent Forms, Osteoarthritis, Knee
Development, Piloting and Evaluation of an Evidence-based Informed Consent Form for Total Knee Arthroplasty
Every medical intervention requires informed consent. Informed consent may include comprehensible information about the necessity and kind of the intervention, material risks and consequences or alternative treatments.
- Conditions
- Consent Forms, Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- EvAb-Pilot (NCT04669483)
- Testing
- evidence-based informed consent form
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Witten/Herdecke
Knee Osteoarthritis, Knee Pain Chronic
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
Dorsal root ganglion stimulation (DRG-S) may be able to treat mechanical pain caused by tissue injury or damage such as trauma or arthritis in addition to pain caused by nerve dysfunction or injury.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT05103527
- Testing
- Dorsal Root Ganglion Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kenneth B Chapman
Osteoarthritis
Efficacy and Safety of Intraarticular Injections of Hyalgan in the Treatment of Osteoarthritis of the Knee
Evaluate the efficacy and safety of Hyalgan, at a dose of 20mg/2ml administered as 5 intraarticular injections at weekly intervals, for the sustained relief of pain and amelioration of joint dysfunction in patients of OA of the…
- Trial name
- NCT01319461
- Testing
- Hyalgan, sterile normal saline
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Med Pharma Co., Ltd.
Knee Osteoarthritis
Effectiveness of a Knee Brace When Combined With Viscosupplementation in the Treatment of Knee Osteoarthritis
Hypothesis: Viscosupplementation when combined with an off-loading knee brace is more effective in treating the symptoms of knee OA then treating with viscosupplementation alone
- Trial name
- NCT01478386
- Testing
- Orthovisc, DonJoy HA lite knee brace, Orthovisc injections and DonJoy HA lite knee brace
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- OAD Orthopaedics
Knee Osteoarthritis
Knee Pain Phenotypes in the Community Study
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over.
- Trial name
- NCT02098070
- Where
- United Kingdom
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Clinical Evaluation of the Levitation Knee Brace
Osteoarthritis (OA) is a debilitating disease affecting approximately 1/3 of Canadians over the age of 25. Knee OA typically involves at least 2 of 3 compartments in the knee joint.
- Trial name
- NCT05543486
- Testing
- Levitation 2 Tri-Compartment Offloader (TCO) knee brace, Knee sleeve
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Establish Implant Accuracy With X-PSI Knee System
The goal of this study is to establish the accuracy of the new X-PSI Knee System guides by analyzing early postoperative (4-6 weeks) imaging data with regards to the mechanical alignment and compare them with preoperative…
- Trial name
- X-PSI (NCT03275246)
- Testing
- X-PSI Knee System
- Where
- 4 sites in Germany, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Zimmer, GmbH
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