Clinical trials: Knee Arthritis Disease
Knee Osteoarthritis
Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis
The purpose of this study is to evaluate the effect of one single intra-articular (IA) injection of HYALUBRIX 60® plus physical exercise program (PEP) in terms of pain reduction, compared to PEP alone, in patients with knee…
- Trial name
- NCT06113783
- Testing
- HYALUBRIX 60
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Gonarthrosis, Total Knee Arthroplasty
Infiltration or Nerve Blocks in Addition to Adductor Canal Block
The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).
- Trial name
- INCA (NCT06920186)
- Testing
- Analgesia
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis
Study Comparing Traditional and Gender-specific Total Knee Replacement Designs
The purpose of this study is to compare results obtained with gender-specific and traditional knee replacement systems design among women undergoing total knee replacement surgery.
- Trial name
- NCT00937170
- Testing
- Zimmer LPS flex Gender Specific Implant (Total knee replacement), Zimmer High Flex LPS Implant (Total knee replacement), Stryker Triathlon Implant (Total knee replacement)
- Sponsor
- UConn Health
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
Knee Arthritis, Osteoarthritis
Platelet-Rich Plasma Composition and Clinical Effects in Knee Osteoarthritis
This is a prospective, observational cohort study involving 40 patients with primary knee osteoarthritis hospitalized in a rehabilitation hospital in Cluj-Napoca.
- Trial name
- NCT07558980
- Testing
- intra-articular administration of plasma rich in platelets (PRP)
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Osteoarthritis, Knee, Pain
St. John's Wort Oil on Osteoarthritis
This study investigated the effect of St. John's Wort oil on pain intensity and physical functions in people with knee osteoarthritis. This study adopted a randomized, placebo-controlled, and qualitative mixed design.
- Trial name
- NCT05663996
- Testing
- locally applied to the skin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Knee Osteoarthritis
Intraarticular Xylitol Injections for Knee Osteoarthritis
Hypothesis: Intraarticular injections of isotonic Xylitol solution will improve pain in patients with knee osteoarthritis (OA).
- Trial name
- NCT02104596
- Testing
- Xylitol
- Where
- Israel
- Volunteers
- 96 people
- Sponsor
- Hadassah Medical Organization
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparison of CoCr Alloy and TiN Coating in TKA
In the current prospective, randomized study, two different materials of the same total knee arthroplasty (TKA) system - cobalt-chromium (CoCr) and titanium-nitride (TiN) - are going to be compared with regards to postoperative…
- Trial name
- NCT04701359
- Testing
- TiN-alloy based total knee arthroplasty, CoCr-coating based total knee arthroplasty
- Where
- Austria
- Sponsor
- Medical University of Graz
Knee Osteoarthritis
Lysyl Oxidase and Lysyl Hydroxylase Levels in Knee Osteoarthritis
The aim of this study is to investigate the serum levels of lysyl hydroxylase, lysyl oxidase, and the lysyl oxidase-like enzymes in patients with different stages of knee osteoarthritis and to compare these findings with those of…
- Trial name
- KNEELOX (NCT07875296)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Osteoarthritis
StepRite Evaluation
The purpose of this study is to compare the short-term changes in gait parameters and functional outcomes after total knee arthroplasty between those who use the StepRite device and those who follow a standard therapy program…
- Trial name
- NCT02270684
- Testing
- StepRite
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Knee Osteoarthritis
Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07381621
- Testing
- Perineural 5% Dextrose Injection, Perineural Local Anesthetic Injection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara Training and Research Hospital
Knee Osteoarthritis, Pes Anserine Bursitis
Effects of Myofascial Release and Neuromuscular Training for Pes Anserine Syndrome Associated With Knee Osteoarthritis
A randomized control trial will be conducted at the outpatient department of Dow Institute of Physical Medicine and Rehabilitation. A sample size of 80 is calculated using PASS version 11 software.
- Trial name
- NCT05529914
- Testing
- Myofascial release, Neuromuscular exercises, Cold pack
- Where
- 2 sites in Pakistan
- Volunteers
- 80 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis, Knee
A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee OA pain.
- Trial name
- NCT06917404
- Testing
- Pentosan Polysulfate Sodium twice weekly
- Where
- 57 sites in United States, Australia and 2 more
- Volunteers
- 466 people
- Sponsor
- Paradigm Biopharmaceuticals Ltd.
Osteoarthritis of the Knee, Arthroscopy
Development of Knee Osteoarthritis After Arthroscopic Partial Resection of Degenerative Meniscus Tear
It has been previously demonstrated that the risk for the development of knee osteoarthritis is increased after both meniscus tear and meniscectomy.
- Conditions
- Osteoarthritis of the Knee, Arthroscopy, Meniscal Tear
- Trial name
- NCT01052233
- Testing
- Arthroscopic partial meniscectomy, Arthroscopy (diagnostic)
- Where
- 5 sites in Finland
- Volunteers
- 160 people
- Sponsor
- Tampere University
Knee Osteoarthritis
sAfety PerfoRmance chitOsan osteOarthritis ViscosupplEmentation
KIO014 is an innovative chitosan-based biomaterial intended for synovial fluid viscosupplementation indicated for the symptomatic treatment of knee osteoarthritis (OA).
- Trial name
- APROOVE (NCT03679208)
- Testing
- Investigational device coded KIO014, Durolane(r) as control device
- Volunteers
- 100 people
- Sponsor
- Kiomed Pharma
Knee Osteoarthritis
Vibratory Stimuli, A Novel Rehabilitation Method for Preventing Post - Traumatic Knee Osteoarthritis
This study will evaluate the acute effects of vibration (whole body vibration and local muscle vibration) on quadriceps function, knee joint proprioception, and gait biomechanics linked to osteoarthritis development in…
- Trial name
- NCT02605876
- Testing
- Whole body vibration, Local muscle vibration
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoarthritis, Knee
Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
To compare the safety and efficacy of celecoxib versus naproxen for the treatment of knee osteoarthritis
- Trial name
- CLOAK (NCT00643799)
- Testing
- Celecoxib, Naproxen
- Where
- 51 sites in United States
- Volunteers
- 586 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Knee Osteoarthritis
Prediction of Pain After Total Knee Arthroplasty
Despite improvements in treatment, a significant part of patients have severe pain following knee arthroplasty. Preoperative identification of high-risk patients would allow for an intensive individualized analgesic treatment…
- Trial name
- NCT02254499
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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