Clinical trials: Knee Arthrofibrosis
ACL Tear, Arthrofibrosis
Knee Split Comparison After ACL Reconstruction
This study will evaluate the efficacy of the Graymont X ERIS Knee Splint brace in the postoperative period of ACL reconstruction to improve range of motion, specifically the achievement of terminal extension and…
- Conditions
- ACL Tear, Arthrofibrosis, ACL Injury
- Trial name
- NCT04360928
- Testing
- Graymont X ERIS Knee Splint, Standard Hinge Knee Brace
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Rush University Medical Center
Manipulation Under Anesthesia
Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement
The specific aim of this study is to evaluate the effect of oral colchicine in primary TKA patients at 3 months following a manipulation under anesthesia.
- Trial name
- Colchine MUA (NCT02926248)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
ACL Injury, ACL Reconstruction
Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction
The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the…
- Conditions
- ACL Injury, ACL Reconstruction, Scar Formation
- Trial name
- NCT07135687
- Testing
- Losartan
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Rush University Medical Center
Cyclop Arthrofibrosis Anterior Cruciate Ligament
Is There a Correlation Between Surgical Technique for Primary Anterior Cruciate Ligament Surgery and the Risk of Subsequent Formation of Fibrous Cyst (Cyclops) in the Knee Joint, Which Leads to the Need for Surgical Removal of the Cyclops?
Fibrous scar tissue formation (Cyclops) after a primary anterior cruciate ligament reconstruction (ACLr) may affect patients' ability to perform work and exercise to such an extent that further arthroscopic surgery may be…
- Trial name
- NCT05301686
- Testing
- Patients with Cyclop lesion
- Where
- Denmark
- Volunteers
- 2,556 people
- Sponsor
- Aarhus University Hospital
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Arthrofibrosis of Knee
Stiffness and Low Dose Irradiation RCT
Acquired idiopathic stiffness (AIS) is a common complication following total knee arthroplasty (TKA). It is caused by excessive scar formation, which leads to pain, loss of motion, and functional impairment.
- Trial name
- LDI TKR RCT (NCT07767097)
- Testing
- Low-Dose External Beam Irradiation, Hinged Revision Total Knee Arthroplasty
- Where
- 4 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Mount Sinai Hospital, Canada
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis, Arthropathy of Knee
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
- Trial name
- NCT03598829
- Testing
- Tryptase, Serum test
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Mayo Clinic
Arthroplasty, Replacement, Knee
Static Progressive Splinting in the Management of Knee Stiffness Following Total Knee Arthroplasty
The purpose of this study is to determine the feasibility and initial efficacy of static progressive splinting for individuals presenting with knee stiffness following total knee arthroplasty (TKA).
- Trial name
- NCT04837872
- Testing
- Multimodal Physical Therapy (MPT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Joint Contractures, Total Knee Anthroplasty
Knee Flexionater to Avoid Motion Restoring Surgery
The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery.
- Conditions
- Joint Contractures, Total Knee Anthroplasty, Knee Arthrofibrosis
- Trial name
- NCT07454356
- Testing
- Hydraulic high Intensity Stretch Device, Standard Physical Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ermi LLC
Arthrofibrosis
Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty
Recent research has focused on methods to mitigate scar tissue formation and arthrofibrosis following surgery in hopes that patients may attain maximal range of motion goals, avoid manipulation and secondary surgery (i.e.
- Trial name
- NCT05157464
- Testing
- Losartan
- Where
- United States
- Sponsor
- NYU Langone Health
Arthroplasty Complications, Fibrosis
Physiotherapy for Arthrofibrosis Following Knee Replacement.
This research aims to develop an optimal physiotherapy intervention for people with arthrofibrosis (stiffness due to scar tissue) after total knee replacement (TKR). We will develop an optimal intervention by conducting: 1.
- Conditions
- Arthroplasty Complications, Fibrosis, Knee Joint Contracture
- Trial name
- ReSTART (NCT05459259)
- Testing
- Interviews and Delphi Survey
- Where
- United Kingdom
- Volunteers
- 145 people
- Sponsor
- University of Nottingham
Arthrofibrosis
STAK Tool for Treatment of Arthrofibrosis Post Total Knee Replacement
A common complication following total knee replacement (TKR) is arthrofibrosis, a severe stiffening of the knee caused by scar tissue.
- Trial name
- STAK (NCT04019847)
- Testing
- STAK Tool, Standard treatment
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Knee Arthroplasty, Total
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.
- Trial name
- NCT06108063
- Testing
- Losartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Steadman Philippon Research Institute
Arthrofibrosis of Knee, Arthrofibrosis of Shoulder
Ultrasound Imaging of Fibrotic Tissue
This project intends to collect the ultrasonic spectrum information of shoulder and knee joint fibrotic tissue, and use machine learning to study the mechanism of fibrosis tissue ultrasound imaging, and then build a model and…
- Trial name
- NCT05818904
- Testing
- Physical Therapy
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Knee Arthrofibrosis
Effects of Instrument Assisted Soft Tissue Mobilization in Addition to Conventional Physiotherapy in Knee Arthrofibrosis
Arthrofibrosis is the abnormal proliferation of fibrous tissue within a joint and around the joint that leads to loss of motion, pain, muscle weakness, swelling, functional limitation.
- Trial name
- NCT06172231
- Testing
- Instrument Assisted Soft tissue mobilization, Conventional therapy
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Foundation University Islamabad
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Werewolf Flow 50 During ACL Reconstruction
The aim of this study is to compare the outcomes, ease of use, and cost of the Werewolf FLOW50 device to the institutional standard of care which is does not include the use of electrocautery devices during anterior cruciate…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
- Trial name
- NCT04998656
- Testing
- Werewolf FLOW 50, Control
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Denver
Arthrofibrosis of Knee
Losartan Use to Mitigate Arthrofibrosis Following Total Joint Arthroplasty
The purpose of this study is to determine the effect of Losartan, an Angiotensin II Receptor Blocker (ARB), on the formation development of arthrofibrosis in patients who have had a primary total knee arthroplasty.
- Trial name
- NCT06333522
- Testing
- Losartan
- Where
- United States
- Sponsor
- NYU Langone Health