Clinical trials: Knee Arthropathy
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Osteoarthritis, Arthritis
Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study
This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo.
- Conditions
- Osteoarthritis, Arthritis, Pain
- Trial name
- NCT01089725
- Testing
- Tanezumab SC, Tanezumab IV
- Where
- 91 sites in United States
- Volunteers
- 385 people
- Sponsor
- Pfizer
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Knee Osteoarthritis
A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate efficacy and safety of YH23537 versus celebrex in patients with knee osteoarthritis.
- Trial name
- NCT02759198
- Testing
- YH23537, Celecoxib
- Where
- South Korea
- Volunteers
- 456 people
- Sponsor
- Yuhan Corporation
Knee Arthropathy
Persona Cohort Nordic Multicenter Study
In this project the investigators wish to: Evaluate intra-operative and postop complications, longer term survivorship and patient reported outcome measures (PROMs) following primary total knee replacement using Persona Total…
- Trial name
- NCT03495232
- Testing
- Zimmer Biomet Persona total knee system
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 700 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy and safety of intraarticular Invossa K Injection patients diagnosed with Kellgren \& Lawrence grade 2 knee osteoarthritis.
- Trial name
- NCT03383471
- Testing
- Invossa K Inj.
- Where
- 17 sites in South Korea
- Volunteers
- 146 people
- Sponsor
- Kolon Life Science
Osteoarthritis
Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
The purpose of this phase III study is to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Patients with Osteoarthritis of the Knee
- Trial name
- NCT00704847
- Testing
- Oral Salmon Calcitonin
- Where
- 18 sites in United States, Belgium and 8 more
- Volunteers
- 1,030 people
- Sponsor
- Nordic Bioscience A/S
Osteoarthritis
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee…
- Trial name
- ITIC (NCT00565812)
- Testing
- SD-6010
- Where
- 183 sites in United States, Argentina and 12 more
- Volunteers
- 1,457 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis
- Trial name
- NCT05789719
- Testing
- STEM-OA
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- StemMedical A/S
Knee Osteoarthritis
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.
- Trial name
- NCT06741098
- Testing
- NCR100, 0.9% Normal saline
- Volunteers
- 162 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis, Knee
Safety and Efficacy of Viscosupplementation of Hyaluronic Acid With Addition of Lecithin in Patients With Mild or Moderate Osteoarthrosis of the Knee Joint.
The main objective of this prospective, open-label clinical trial is to assess the effectiveness and safety of intra-articular liposomal gel therapy for knee OA symptoms.
- Trial name
- NCT06433492
- Testing
- Intra-articular injection
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Biovico Sp. z o.o.
Osteoarthritis
A Clinical Investigation of the Oxford® Partial Knee System
The purpose of this prospective data collection is to document the performance and clinical outcomes of the Oxford® Partial Knee System.
- Trial name
- NCT00699257
- Volunteers
- 85 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis of Knee
A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee
A Multi-Centre, Parallel, Double-Blind, Active comparator, Randomised phase III Clinical Trial
- Trial name
- NCT02893098
- Testing
- Humia inj., High hyal Plus inj.
- Where
- South Korea
- Volunteers
- 232 people
- Sponsor
- Huons Co., Ltd.
Knee Osteoarthritis, Hip Osteoarthritis
The Kaia Hip and Knee Pain Intervention for Self-management of the Pain in Patients With Osteoarthritis.
The study intervention provides an innovative way of making exercise training and other recommended lifestyle modifications as accessible as possible for knee and hip OA participants by introducing a home-based exercise training…
- Trial name
- PIVOT (NCT04615377)
- Testing
- Kaia hip and knee pain application, Treatment as usual
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Kaia Health Software
Osteoarthritis, Knee
A First-in-Human Study of XSTEM-OA in Patients With Knee Osteoarthritis
The aim of the study is to assess safety, tolerability and preliminary efficacy of XSTEM-OA when administered as a single intra-articular injection to patients with symptomatic knee osteoarthritis.
- Trial name
- NCT05344157
- Testing
- XSTEM-OA
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Xindu Pty Ltd
Osteo Arthritis of the Knee
Hydrogel Assessment for Local Treatment of Osteoarthritis
The study aims to evaluate the safety and tolerability of one intra-articular injection of Hydrogel OA 2% for the symptomatic treatment of osteoarthritis of the knee.
- Trial name
- HALO (NCT07516457)
- Testing
- Injection of Hydrogel OA 2%
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Allegro NV/SA
Painful Osteoarthritis of the Knee
A Study of the Efficacy and Safety of MEDI7352 in Participants With Painful Osteoarthritis of the Knee
This is a Phase IIb randomised, double-blind, placebo-controlled, dose-response study in participants with painful osteoarthritis (OA) of the knee.
- Trial name
- BESPOKE (NCT04675034)
- Testing
- MEDI7352
- Where
- 41 sites in Denmark, Estonia and 4 more
- Volunteers
- 345 people
- Sponsor
- AstraZeneca
Knee Osteoarthritis
Comparative Evaluation of A-CP HA Kit, Hyaluronic Acid and Placebo for the Treatment of Knee Osteoarthritis
Hyaluronic acid (HA) is a major component of synovial fluid, to which it confers viscosity and elasticity. It has been shown that the rheological properties of the synovial fluid decrease in patients with osteoarthritis.
- Trial name
- NCT03201614
- Testing
- A-CP HA Kit, ArthroVisc 40
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Regen Lab SA
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
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