Clinical trials: Knee Arthrosis,
Osteoarthritis, Knee
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
In this, prospective, double-blind study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of leukocyte poor, platelet-rich plasma or hyaluronic acid injections under…
- Trial name
- HA vs PRP (NCT02588872)
- Testing
- Platelet-rich Plasma (PRP), Hyaluronic Acid
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Anterior Knee Pain Syndrome
Use of Hyaluronic Acid Injection in Lateral Patellar Compression With Femoral Condylar Degenerative Changes After Arthroscopic Release
Ninety patients are involved in this study, who underwent arthroscopic lateral patellar release for lateral patellar compression syndrome and they had patellofemoral degenerative lesion, which diagnoses by MRI preoperatively and…
- Trial name
- NCT04134611
- Testing
- Hyaluronic acid injection, No injection of Hyaluronic acid
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Hawler Medical University
Pain
Continuous Femoral Nerve Block Following Total Knee Replacement
The purpose of this study is to determine if putting local anesthetic-or numbing medication-through a tiny tube next to the nerves that go to the knee will improve pain control during physical therapy, and ultimately improve the…
- Trial name
- NCT00135889
- Testing
- Femoral perineural infusion
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Osteoarthritis, Knee, Nociceptive Pain
The Post-operative Analgesia of the Virtual Reality Using a Mirror Therapy After Total Knee Arthroplasty
It was well known that the mirror therapy could decrease pain of upper-limb amputated patients. The mirror therapy is known to make a plastic change some parts of the brain perceiving the painful body part and modulating its…
- Conditions
- Osteoarthritis, Knee, Nociceptive Pain, Virtual Reality
- Trial name
- NCT01979718
- Testing
- Mirrored Virtual reality
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ulsan University Hospital
Knee Osteoarthritis
Assessment of the Efficacy of Stromal Vascular Fraction Treatment for Knee Osteoarthritis
One-year follow-up prospective observational study involving male and female patients (over 18-years-old) with unilateral or bilateral knee osteoarthritis treated with intraarticular injection of stromal vascular fraction (SVF)…
- Trial name
- NCT04749758
- Testing
- SVF treatment
- Where
- Andorra
- Volunteers
- 66 people
- Sponsor
- University of Andorra
Osteoarthritis, Knee
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain - Dose escalation
- Trial name
- NCT03282149
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Xalud Therapeutics, Inc.
Knee Osteoarthritis
Turmeric, Black Seeds, Flaxseed and Medicago Sativa in Knee Osteoarthritis
This study investigates the safety and combined effect of Turmeric, Black Seeds, Flaxseed, and Medicago Sativa for relieving symptoms of knee osteoarthritis compared to the placebo group.
- Trial name
- NCT05723458
- Testing
- Cream
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tabriz University of Medical Sciences
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Knee Osteoarthritis
Circuit Training on Knee Osteoarthritis Patients
Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA.
- Trial name
- NCT02761590
- Testing
- Circuit training protocol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos
Knee Osteoarthritis, Vitamin D Deficiency
Prospective, Assessment of Vitamin D and Calcium Supplementation, Improvement of Nutritional Status and Preoperative Rehabilitation in Patients Before Knee Arthroplasty.
Prospective randomized study of 150 patients qualified for knee arthroplasty between 2015 and 2017. Patients were randomized into 3 groups receiving vitamin D and calcium supplementation, increased protein supply and preoperative…
- Conditions
- Knee Osteoarthritis, Vitamin D Deficiency, Pain, Postoperative, Arthropathy of Knee
- Trial name
- NCT04291833
- Testing
- Intervention group 1, Intervention group 2, Control group 0
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Jagiellonian University
Knee Osteoarthritis
Exercise and Steroid in Knee Osteoarthritis
Osteoarthritis (OA) of the knee is a very common chronic joint disorder associated pain and disability. As no cure exists, management aims to reduce pain, improve function, and enhance quality of life.
- Trial name
- NCT01945749
- Testing
- Intraarticular steroid, Intraarticular saline, Exercise therapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Frederiksberg University Hospital
Knee Osteoarthritis
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis
To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.
- Trial name
- NCT05398874
- Testing
- Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR)
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Kufa University
Knee Osteoarthritis
Pain Compared Between the First and the Second Surgery in Staged BTKA
postoperative pain and analgesic consumption between the first and the second surgery would be compared in patients undergoing staged bilateral total knee arthroplasty (BTKA).
- Trial name
- NCT01457313
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Opioid Use, Arthropathy of Knee
Opioid Consumption After Hospital Discharge in Orthopedic Surgery
At the Ohio State University, and across the country, surgical patients admitted to the hospital are over-prescribed a significant amount of opioid medications upon discharge to home.
- Conditions
- Opioid Use, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT03185117
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Ohio State University
Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain
Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)
The current study examines the effects of milnacipran in patients who have chronic persistent knee pain one year or longer after total knee arthroplasty (TKA) to evaluate for a pain-relieving effect.
- Trial name
- NCT01780389
- Testing
- Open-label flexibly dosed milnacipran
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Knee
Delivra-Celecoxib 8% Cream and Osteoarthritis
This is an observation of the current use of a transdermal preparation of Celecoxib 8% which is being used in the treatment of patients with primary OA of the knees. Subjects will be followed for 12 weeks.
- Trial name
- NCT03698916
- Testing
- Celecoxib cream 8%
- Where
- 3 sites in Canada
- Volunteers
- 6 people
- Sponsor
- Credit Valley Rheumatology
Osteoarthritis, Knee
Tolerability and Efficacy of Ibuprofen 800 mg in a Walking Model of Osteoarthritis Pain (0000-057)
The purpose of the study is to see if generic ibuprofen has an effect on osteoarthritis knee pain during a series of timed walks on a treadmill.
- Trial name
- NCT00565084
- Testing
- ibuprofen
- Volunteers
- 33 people
- Sponsor
- Merck Sharp & Dohme LLC
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