Clinical trials: Knee Arthrosis,
Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the knee.
- Trial name
- NCT02844751
- Testing
- [StroMed + platelet rich plasma (PRP)], [PRP] platelet rich plasma
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- VivaTech International, Inc.
Osteoarthritis, Hip, Osteoarthritis, Knee
Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee.
Tanezumab is a monoclonal antibody that binds to and inhibits the actions of nerve growth factor (NGF). The Nerve Growth Factor Inhibitor (NGFI) class may offer an important breakthrough in the treatment of chronic pain and is…
- Trial name
- NCT02709486
- Testing
- Tanezumab
- Where
- 148 sites in Austria, Bulgaria and 13 more
- Volunteers
- 849 people
- Sponsor
- Pfizer
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
Joint Disease
Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis
The primary objective is to compare the overall treatment effect on pain relief between icatibant and placebo. The secondary objectives are to assess the efficacy of icatibant in term of onset, extent and duration of pain relief…
- Trial name
- NCT00303056
- Testing
- HOE140 Icatibant
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 590 people
- Sponsor
- Sanofi
Mild to Moderate Knee OA
A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees
To evaluate the long-term changes in patellar cartilage thickness in TPX-100 versus placebo-treated knees in subjects who participated in Study TPX-100-1 or TPX-100-2.
- Trial name
- NCT03125499
- Testing
- Previous treated with TPX-100
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- OrthoTrophix, Inc
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Osteoarthritis, Knee
Oxford Signature vs. Conventional Global Study
This study will compare alignment criteria in the Oxford Partial Knee using conventional instrumentation and Signature Custom Guides in order to determine if the use of the Signature Custom Guides results in a higher percentage…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis
- Trial name
- NCT01763684
- Testing
- Signature Custom Guides, Conventional Instrumentation
- Where
- 7 sites in United States
- Volunteers
- 266 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis, Hip
Autologous Adipose Tissue-Derived Mesenchymal Stem Cells (AdMSCs) for Osteoarthritis
This is a phase 2 open-label, 6 arms (1 study group and 1 control group for each joint category), randomized control group clinical study with 300 subjects diagnosed with osteoarthritis of knees (n=100), hips (n=100) and…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Shoulder
- Trial name
- AdMSCs (NCT04448106)
- Testing
- Celltex- AdMSCs
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Celltex Therapeutics Corporation
Knee Osteoarthritis
Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI)
The main purposes of this study are: to determine the effects of chondroitin sulphate on brain response to pain assessed through fMRI in patients with knee osteoarthritis.
- Trial name
- NCT01226615
- Testing
- Chondroitin sulphate (Condrosan®)
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Bioiberica
Osteoarthritis, Post-traumatic Arthritis
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
A clinical trial investigating the safety and effectiveness of Smith and Nephew's FDA-approved Porous Total Knee System, which is used to replace worn away and diseased knee joints.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT05197036
- Testing
- Total Knee Arthroplasty
- Where
- 18 sites in United States, Australia and 3 more
- Volunteers
- 299 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Evaluating the Efficacy and Safety of Intra-articular Injection of HS-20116 in Patients With Knee Osteoarthritis
The purpose of this trial is to evaluate the efficacy and safety of HS-20116 for intra-articular use in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07047196
- Testing
- HS-20116, Medical Chitosan (for intra-articular injection)
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Osteoarthritis, Knee
MOTION Clinical Trial
Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment.
- Trial name
- NCT06843980
- Testing
- MISHA Knee System, Non-Surgical Treatment
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Moximed
Osteoarthritis of the Knee
Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
This study valuates the safety and efficacy of treatment with 3% Diclofenac Nano-Emulsion Cream versus Placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00484120
- Testing
- 3%-Diclofenac-Nano-Emulsion Cream
- Where
- 4 sites in Israel
- Volunteers
- 123 people
- Sponsor
- Pharmos
Knee Osteoarthritis
Study on Knee Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease characterized macroscopically by progressive damage of articular cartilage, joint space narrowing, subchondral bone remodelling, joint marginal osteophyte formation and…
- Trial name
- PILHAC (NCT06097988)
- Testing
- ABIO3419
- Where
- 2 sites in Latvia
- Volunteers
- 20 people
- Sponsor
- Symatese
Total Knee Arthroplasty, Osteoarthritis
A Study to Compare the NexGen CR and CR-Flex Knee Implants
The purpose of this study is to test for significant differences in functional outcomes, specifically pre-operative ROM and post-operative ROM obtained by using a NexGen CR versus a NexGen CR-Flex knee implant.
- Trial name
- NCT00761956
- Testing
- NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee
- Where
- 8 sites in United States
- Volunteers
- 189 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial
This study is a prospective, multicenter (up to 4 sites), randomized, double-blind, two-arm study. Forty-five (45) patients will be randomized to receive a single 4-6 ml intra-articular (IA) injection of either the output of ACP…
- Trial name
- NCT05765266
- Testing
- ACP Max™, Depo-Medrol®
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Arthrex, Inc.
Degenerative Arthritis, Osteoarthritis
I-beam and Cruciate Tibial Components Used in Total Knee Replacement
The purpose of this study is to compare the clinical outcomes of using an I-beam or cruciate tibial component in total knee replacement.
- Conditions
- Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
- Trial name
- NCT00588783
- Testing
- I-beam design, Cruciate design
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis of the Knee
Hydros and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis
The purpose of this study is to evaluate the safety and efficacy of Hydros-TA Joint Therapy for relief of pain due to OA of the knee.
- Trial name
- NCT02022930
- Testing
- Hydros, Hydros-TA, Triamcinolone Acetonide
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 510 people
- Sponsor
- Carbylan Therapeutics, Inc.
Knee Osteoarthritis, Knee Arthritis
ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)
ROMTech is focused on transforming the healthcare market by delivering lower extremity rehabilitation systems that are effective, efficient for patient use, cost-effective, and provide better patient outcomes while simultaneously…
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT04497129
- Testing
- ROMTech PortableConnect, Traditional Rehabilitation and CPM Device
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- ROM Technologies, INC
Osteoarthritis of the Knee
Effects of Aquamin F on Osteoarthritis of the Knee
The objective of this trial is to evaluate the effect of Aquamin F alone or in combination with glucosamine sulfate versus placebo on symptoms of joint pain, stiffness and immobility in subjects with painful osteoarthritis of the…
- Trial name
- NCT00452101
- Testing
- Aquamin F
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Marigot Ltd.
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