Clinical trials: Knee Arthrosis,
Osteoarthritis, Pain
Study of OLT1177 Gel to Treat Moderate to Severe OA Knee Pain
The objectives of this trial are to investigate the efficacy and safety of six weeks of treatment with OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain…
- Trial name
- NCT02104050
- Testing
- OLT1177 Gel
- Where
- 13 sites in United States
- Volunteers
- 202 people
- Sponsor
- Olatec Therapeutics, Inc.
Osteoarthritis
Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA
The purpose of this study is to demonstrate non-inferiority of three weekly intra-articular injections of SUPARTZ to three weekly intra-articular injections of Euflexxa for the relief of knee OA.
- Trial name
- NCT02110238
- Testing
- Supartz, Euflexxa
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Bioventus LLC
Osteoarthritis
Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.
The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy…
- Trial name
- NCT00484718
- Testing
- celecoxib, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Study of Intra-articular Allocetra in Knee Osteoarthritis
This is a double blind, randomized,multi-center study to evaluate the safety and efficacy of intra-articular administration of Allocetra compared to placebo in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT06233474
- Testing
- Allocetra
- Where
- 12 sites in Denmark, Israel and 1 more
- Volunteers
- 160 people
- Sponsor
- Enlivex Therapeutics Ltd.
Chronic Pain
A Study of MEDI7352 in Painful Osteoarthritis of the Knee
The purpose of this study is to assess the safety, drug levels and effects on the body of MEDI7352, in subjects with painful osteoarthritis of the knee.
- Trial name
- NCT02508155
- Testing
- MEDI7352 for IV infusion, MEDI7352 for Subcutaneous Injection
- Where
- 6 sites in Germany, Sweden and 1 more
- Volunteers
- 132 people
- Sponsor
- AstraZeneca
Osteoarthritis
TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis
This study will evaluate the efficacy and safety of intra-articular injections of 20 mg/2mL dose HYALGAN in patients with pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT00130468
- Testing
- Hyalgan (sodium hyaluronate)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Sanofi
Osteoarthritis
Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain
The purpose of this study is to evaluate the safety and efficacy of a low dose and a high dose of Meloxicam SoluMatrix® Capsules versus Meloxicam Tablets for the treatment of pain due to osteoarthritis of the knee or hip.
- Trial name
- NCT02405793
- Testing
- Meloxicam Test Capsules, Meloxicam Tablets
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis of the Knee
Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis. It can cause pain, swelling, and reduced motion in the joints. That can reduce quality of life.
- Trial name
- NCT01119898
- Testing
- PENNSAID Gel, Vehicle
- Where
- 26 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mallinckrodt
Knee Osteoarthritis
Knee Biofeedback Rehabilitation Through Game Therapy
The goal of this study is to learn about the effect of video-game based rehabilitation exercise for patients with knee osteoarthritis.
- Trial name
- KneeBRIGHT (NCT06090097)
- Testing
- KneeBRIGHT System, Control Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Barron Associates, Inc.
Knee Osteoarthritis
Knee Osteoarthritis and Thermal Spa Treatment
The goal of this interventional study is to evaluate the effectiveness at 6 months of the Enghien-les-Bains thermal spa treatment on functional disability and pain, assessed by the Minimal Clinically Important Improvement (MCII)…
- Trial name
- ENERGIE (NCT07370480)
- Testing
- Thermal spa sessions, Thermal water, Standard of Care for Knee Osteoarthritis
- Where
- 2 sites in France
- Volunteers
- 76 people
- Sponsor
- CEN Biotech
Osteoarthritis, Knee
Efficacy and Safety of Lumiracoxib in Patients With Knee Osteoarthritis (OA).
This study will investigate the efficacy and safety of lumiracoxib in patients with primary knee osteoarthritis (OA).
- Trial name
- NCT00366938
- Testing
- Lumiracoxib
- Where
- United States
- Volunteers
- 1,464 people
- Sponsor
- Novartis
Knee Osteoarthritis
Evaluation of the Safety and Effectiveness of the Kinamed Gem Ceramic Femoral Component for Total Knee Replacement
The aim of this study is to provide evidence that the safety and effectiveness of the ceramic femoral component of the Gem Total Knee System is similar to FDA approved implants used in total knee replacement surgery.
- Trial name
- NCT00743717
- Testing
- zirconia femoral component, cobalt chrome femoral component
- Volunteers
- 4 people
- Sponsor
- Kinamed Incorporated
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
Knee Arthropathy
Physica TT Tibial Plate Follow up Study
This clinical study aims at evaluating clinical, radiographic, patient-reported outcomes of total knee arthroplasty with Physica TT Tibial Plate in combination with Physica Porous KR or Physica Porous PS up to 2 years after…
- Trial name
- NCT06337123
- Testing
- Device: Physica TT TIbial Plate and Physica Porous KR, Device: Physica TT TIbial Plate and Physica Porous PS
- Where
- 3 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Limacorporate S.p.a
Chronic Pain, Osteoarthritis, Hip
Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term joint safety and efficacy (pain relief) of the investigational study drug, tanezumab compared to non-steroidal anti inflammatory drugs (NSAIDs) in subjects with osteoarthritis…
- Conditions
- Chronic Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT02528188
- Testing
- NSAID, Tanezumab 2.5 mg, Tanezumab 5 mg
- Where
- 507 sites in United States, Australia and 16 more
- Volunteers
- 3,021 people
- Sponsor
- Pfizer
Knee Pain Chronic, Osteoarthritis
Persona Ti-Nidium Post-Market Clinical Follow-up
The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- TKA (NCT04817969)
- Testing
- Zimmer Biomet Persona Ti-Nidium Total Knee System
- Where
- 7 sites in United States
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Knee Pain
The Effects of Transcutaneous Electrical Nerve Stimulation on People With Knee Osteoarthritis (OA) and or Chronic Pain
The purpose of this study is to evaluate the effect of TENS at the knee pain.
- Trial name
- NCT04084236
- Testing
- electrical stimulation
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Omron Healthcare Co., Ltd.
Knee Osteoarthritis
Durolane Versus Methylprednisolone in Knee Osteoarthritis
The primary objective is to determine whether Durolane is non-inferior to methylprednisolone, as assessed by level of pain, when each are given as single intra-articular injections for the relief of pain, in the treatment of…
- Trial name
- NCT01209364
- Testing
- Durolane is a device, methylprednisolone in a drug
- Where
- 23 sites in Canada, Sweden and 1 more
- Volunteers
- 442 people
- Sponsor
- Galderma R&D
Osteoarthritis
Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial II
The objective of this study is to evaluate the efficacy and safety of TDS-943 (topical diclofenac spray) compared to oral celecoxib and placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00546832
- Testing
- TDS-943 (topical diclofenac sodium 4% spray), celecoxib
- Where
- 49 sites in United States
- Volunteers
- 650 people
- Sponsor
- Mika Pharma GmbH
Participants With Obesity and Knee Osteoarthritis
A Trial of Ribupatide Injection in Participants With Obesity and Knee Osteoarthritis
The study is being conducted to evaluate the efficacy and safety of Ribupatide Injection in participants with obesity and knee osteoarthritis, and to explore its improvement on knee joint structure.
- Trial name
- NCT07709910
- Testing
- Ribupatide Injection
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
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