Clinical trials: Knee Arthrosis,
Meniscus; Degeneration, Osteoarthritis, Knee
Treatment of the Medial Meniscus With the NUsurface(R) Meniscus Implant
This is a prospective, multi-center, open label, non-randomized study, evaluating the treating of medial meniscus deficiency with the NUsurface Meniscus Implant.
- Trial name
- NCT01712191
- Testing
- NUsurface Meniscus Implant
- Where
- 10 sites in Belgium, Germany and 4 more
- Volunteers
- 128 people
- Sponsor
- Phoenix Kinetics
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis (PVNS)
An Open-Label Study of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the Knee
AMB-051-01 is a multicenter study with an adaptive design that will enroll subjects with Tenosynovial Giant Cell Tumor (TGCT) of the knee for 12 weeks of multiple-dose, open-label treatment with intra-articular AMB-05X.
- Trial name
- NCT04731675
- Testing
- AMB-05X
- Where
- 6 sites in United States, Netherlands and 2 more
- Volunteers
- 11 people
- Sponsor
- AmMax Bio, Inc.
Knee Osteoarthritis
Effectiveness of Two Hyaluronic Acids in Osteoarthritis of the Knee
The purpose of this study is to assess whether a single injection hyaluronic acid (HA) product is not inferior to a 3 injection HA product at 24 weeks (6 months), in terms of effectiveness in reducing pain when walking in…
- Trial name
- NCT01543737
- Testing
- 3ml hyaluronic acid (DUROLANE), 2ml hyaluronic acid, (HYALGAN)
- Where
- 17 sites in France, Monaco
- Volunteers
- 290 people
- Sponsor
- Bioventus LLC
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Osteoarthritis, Knee
Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (Europe)
To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.
- Trial name
- NCT00630929
- Testing
- Ibuprofen, Celecoxib
- Where
- 33 sites in Germany, Spain and 1 more
- Volunteers
- 388 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Acute Pain (Flare) Associated With Osteoarthritis (OA) of the Knee
Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee
The primary objective of the study is to assess analgesic efficacy of Impracor (Ketoprofen 10% Cream) compared to placebo for acute pain associated with OA flare of the knee.
- Trial name
- NCT01890902
- Testing
- Ketoprofen 10% Cream
- Sponsor
- Imprimis Pharmaceuticals, Inc.
Arthritis, Osteoarthritis
Tanezumab In Osteoarthritis Of The Knee (2)
The purpose of this study is to test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis.
- Trial name
- NCT00830063
- Testing
- tanezumab 10 mg, tanezumab 5 mg, naproxen
- Where
- 94 sites in United States
- Volunteers
- 832 people
- Sponsor
- Pfizer
Pain
A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee
The purpose of the study is primarily to determine the safety and toleration and pharmacokinetics of PF-05089771 following escalating multiple doses lasting for 14 days.
- Trial name
- NCT01529671
- Testing
- PF-05089771
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain, Low Back Pain
An Efficacy and Safety Study for Tapentadol Extended Release (JNS024ER) in Chronic Pain Participants
The purpose of this study is to evaluate the efficacy, safety and to explore the pharmacokinetics (how drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time) of…
- Conditions
- Pain, Low Back Pain, Back Pain, Osteoarthritis, Knee
- Trial name
- NCT01124604
- Testing
- Tapentadol Hydrochloride
- Where
- 19 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.
Osteoarthritis, Osteo Arthritis Knee
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
This study is being conducted to evaluate the safety and tolerability of OA-SYS in patients with moderate to severe OA of the knee joint.
- Trial name
- OA-SYS-01 (NCT06485843)
- Testing
- OA-SYS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ageless Biotech, Inc.
Osteoarthritis, Knee
Investigating the Effect of Deep Sea Krill Oil Supplementation in Osteoarthritis of the Knee
To evaluate the effectiveness of 4 g Swisse High Strength Deep Sea Krill Oil (Superba BOOST) daily on pain reduction in adults with mild to moderate osteoarthritis of the knee compared to placebo over a 6 month period.
- Trial name
- NCT03483090
- Testing
- Swisse High Strength Deep Sea Krill Oil
- Where
- 4 sites in Australia
- Volunteers
- 235 people
- Sponsor
- Swisse Wellness Pty Ltd
Knee Osteoarthritis
CRx-102 Osteoarthritis Multicenter Evaluation Trial
CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone.
- Trial name
- COMET-1 (NCT00521989)
- Testing
- CRx-102 (2.7/90), Prednisolone, CRx-102 (2.7/180)
- Where
- 58 sites in United States, Canada
- Volunteers
- 279 people
- Sponsor
- Zalicus
Osteoarthritis, Knee
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
This is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function…
- Trial name
- NCT04440189
- Testing
- GID SVF-2 Device System
- Where
- 9 sites in United States
- Volunteers
- 114 people
- Sponsor
- GID BIO, Inc.
Arthropathy of Knee, Arthritis and/or Post-traumatic Degenerative Problems
Optetrak Posterior Stabilized Versus Optetrak Hi-Flex
The purpose of this study is to evaluate the differences in clinical outcomes between the Optetrak® Posterior Stabilized ("Optetrak® PS", Exactech, Gainesville, FL) and the Optetrak® Hi-Flex™ ("Optetrak® HF", Exactech…
- Trial name
- NCT00808613
- Testing
- Optetrak PS, Optetrak Hi-Flex
- Where
- United States
- Sponsor
- Exactech
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
Osteoarthritis,Knee
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stromal Cell Product (RegStem)
Osteoarthritis (OA) is a common and incurable disease for the elderly in Taiwan, so it is an important mission to develop a new treatment for OA.
- Trial name
- NCT03007576
- Testing
- RegStem
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- EMO Biomedicine Corporation
Pain, Osteoarthritis
APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee
The mechanism of Osteoarthritis (OA) is complex, however the investigators know that cartilage breakdown follows changes in certain cells in the cartilage called chondrocytes, leading to proteases that break down cartilage.
- Trial name
- NCT02210468
- Testing
- APIC-CF, 4 cc, APIC-CF, 2 cc
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cytonics Corporation
Unilateral Knee Osteoarthritis
Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis
This was a study that compared Durolane injections to saline injections in the treatment of unilateral osteoarthritis of the knee.
- Trial name
- NCT01806207
- Testing
- Durolane injection, Saline injection
- Where
- United Kingdom
- Volunteers
- 218 people
- Sponsor
- Galderma R&D
Osteoarthritis of Knee
Efficacy and Safety of MM-II for Treatment of Knee Pain in Subjects With Symptomatic Knee Osteoarthritis
This is a phase IIb, randomized, double-blind, placebo-controlled study to determine the efficacy and safety of MM-II in subjects with symptomatic knee OA as compared to matching placebo.
- Trial name
- NCT04506463
- Testing
- MM-II dose I, MM-II dose II, MM-II dose III
- Where
- 25 sites in United States, Denmark and 1 more
- Volunteers
- 397 people
- Sponsor
- Sun Pharmaceutical Industries Limited
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