Clinical trials: Knee Arthrosis,
Osteoarthritis, Knee
A Bioequivalence Study Using Clinical Endpoint for Diclofenac Sodium Gel 1% in Osteoarthritis Knee"
This randomized, double-blind, three-arm, placebo controlled, bioequivalence study with clinical endpoint has been designed to establish clinical equivalence and safety of Mylan's diclofenac gel in the symptomatic treatment of…
- Trial name
- NCT03172780
- Testing
- Diclofenac sodium gel 1%, Voltaren® Gel (Diclofenac Sodium Topical Gel) 1%
- Where
- 32 sites in India
- Volunteers
- 1,220 people
- Sponsor
- Mylan Pharmaceuticals Private Limited
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA).
- Trial name
- NCT00348010
- Testing
- Tramadol HCl ER
- Volunteers
- 245 people
- Sponsor
- Bausch Health Americas, Inc.
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Osteoarthritis, Knee
Efficacy and Safety of an Active Pulsed Electromagnetic Field for the Treatment of Osteoarthritis of the Knee
The hypothesis of this study is that exposure to PEMF alters the cytokine environment of OA joints associated with a reduction of inflammation and improved homeostasis of the extracellular matrix (ECM), both potentially effecting…
- Trial name
- NCT02436590
- Testing
- Orthofix Physio-Stim Model 3315OA
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Orthofix Inc.
Osteoarthritis, Knee
Intra-articular Polyacrylamide Hydrogel in the Treatment of Knee Osteoarthritis
1-year follow-up of a randomized controlled trial with open-label extension to assess the long-term efficacy and safety of Intra-articular HBISA Endoprosthesis of Synovial Fluid NOLTREX™ in Knee Osteoarthritis.
- Trial name
- NCT06523491
- Where
- 2 sites in Russia
- Volunteers
- 57 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee…
- Trial name
- ITIC (NCT00565812)
- Testing
- SD-6010
- Where
- 183 sites in United States, Argentina and 12 more
- Volunteers
- 1,457 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Efficacy of UniRelieverTM Offloading Brace in the Management of Knee Osteoarthritis
The objective of this study is to assess the efficacy and performance of a new semi-rigid offloading brace in the management of knee osteoarthritis.
- Trial name
- UNIBRACE (NCT05905809)
- Testing
- UniRelieverTM offloading brace (THUASNE), Unloader One® X brace (Össur)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Thuasne
Osteoarthritis of the Knee or Hip
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
The primary objective of the study is to describe the safety and tolerability of fasinumab, including adverse events of special interest (AESIs), in patients with pain due to radiographically-confirmed OA of the knee or hip.
- Trial name
- FACT LTS & OA (NCT02683239)
- Testing
- Fasinumab
- Where
- 149 sites in United States, Bulgaria and 19 more
- Volunteers
- 5,331 people
- Sponsor
- Regeneron Pharmaceuticals
Dislocated Patella, Torn Medial Patellofemoral Ligament
Repair of Medial Patellofemoral Ligament Compared to Conservative Treatment for First Time Patella Dislocation
Background: The forces involved in a patella dislocation event can cause significant collateral damage involving the articular cartilage of the patella femoral joint.
- Trial name
- NCT02185001
- Testing
- Direct Medial Patellofemoral Ligament (MPFL) Repair, Physical therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Orthopedic Specialty Institute
Osteoarthritis, Knee
SI-613 Study for Knee Osteoarthritis
The objective of the study is to evaluate the efficacy and safety of intra-articular injections of SI-613 compared with placebo for knee OA.
- Trial name
- NCT03209362
- Testing
- SI-613
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Seikagaku Corporation
Osteoarthritis of the Knee
A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee
To evaluate the efficacy and safety of CLS2901C human allogenic chondrocyte sheets used in the osteotomy + RMSC group compared to in the osteotomy alone group of patients with osteoarthritis of the knee (OAK).
- Trial name
- NCT06549686
- Testing
- CLS2901C (human [allogeneic] chondrocyte sheets)
- Where
- 6 sites in Japan
- Volunteers
- 96 people
- Sponsor
- CellSeed Inc.
Osteoarthritis, Knee
An Open-Label Long-term Safety Study of Tramadol HCl OAD (Once A Day) 300 mg in the Treatment of Pain Due to Osteoarthritis of the Knee
The purpose of this study is to collect information regarding the long-term (6 and 12 months) safety of Tramadol HCl Once-A-Day(OAD) 300 mg.
- Trial name
- NCT00833911
- Testing
- Tramadol Once A Day
- Volunteers
- 392 people
- Sponsor
- Labopharm Inc.
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
Osteoarthritis of the Knee
The Study to Evaluate Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee
The purpose of this study is to evaluate efficacy and safety of Imotun capsule in osteoarthritis of the knee
- Trial name
- ABSOLUTE-OS (NCT01743287)
- Testing
- Imotun capsule
- Where
- 10 sites in South Korea
- Volunteers
- 234 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Osteo Arthritis Knee
Safety and Efficacy of JointAlive™ on the Knee-joint Function in Adults With Knee Arthritis
Osteoarthritis (OA) is a joint disorder caused by wear and tear on the joint over time; as a result, the protective cartilage of the bone in the joint gradually wears down.
- Trial name
- NCT04395547
- Testing
- JointAlive™
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Chenland Nutritionals Inc.
Osteoarthritis, Pain
Study of Safety, Efficacy of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3007
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are…
- Trial name
- NCT02301234
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Celecoxib 100 mg
- Where
- 64 sites in United States, Australia and 9 more
- Volunteers
- 111 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Knee, Musculoskeletal Diseases
A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
This clinical study is to evaluate the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic knee osteoarthritis (OA).
- Trial name
- NCT00131352
- Testing
- hylan G-F 20, Phosphate Buffered Saline
- Where
- 21 sites in Belgium, Czechia and 4 more
- Volunteers
- 253 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis
Safety Extension Study Of Tanezumab When Administered By Subcutaneous Injection To Patients With Osteoarthritis
An evaluation of the long term safety of tanezumab when administered by subcutaneous injection every 8 weeks for up to 64 weeks
- Trial name
- NCT01127893
- Testing
- Tanezumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pfizer
Knee Osteoarthritis
MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis
The purpose of this study was to evaluate the safety and efficacy of lorecivivint (LOR) injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT03706521
- Testing
- lorecivivint
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Musculoskeletal Abnormalities
Prospective Evaluation Assessing U2 MB™ Total Knee System
The goal of this study is to evaluate the safety and effectiveness of the United Orthopaedics Mobile Bearing Total Knee System (U2 MB™ Knee) in patients undergoing total knee replacement surgery due to end-stage knee…
- Trial name
- NCT06996158
- Volunteers
- 150 people
- Sponsor
- MSK Doctors & Associates Ltd
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