Clinical trials: Knee Arthrosis,
Osteoarthritis, Knee
PAAG-OA Treatment for Knee Osteoarthritis
This is a multi-centre, prospective, open-label, uncontrolled, clinical investigation followed by an open-label extension clinical investigation to evaluate PAAG-OA in patients with knee osteoarthritis.
- Trial name
- IDA (NCT04179552)
- Testing
- PAAG-OA
- Where
- 3 sites in Denmark
- Volunteers
- 49 people
- Sponsor
- Contura
Osteoarthritis, Knee, Osteoarthritis, Hip
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared with placebo, when administered for up to 16 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA1 (NCT03161093)
- Testing
- Fasinumab, Naproxen
- Where
- 139 sites in United States, Denmark and 10 more
- Volunteers
- 3,307 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis
Clinical Trial to Evaluate Efficacy and Safety of SMUP-IA-01 in Patients With Knee Osteoarthritis
This clinical trial is for patients who have been diagnosed with Kellgren-Lawrence (K\&L) Grade 2 or 3 knee osteoarthritis on radiographic examination.
- Trial name
- NCT05182034
- Testing
- SMUP-IA-01(low dose), SMUP-IA-01(mid dose), Active Control Group Sodium chloride
- Where
- 5 sites in South Korea
- Volunteers
- 94 people
- Sponsor
- Medipost Co Ltd.
Osteoarthritis, Knee
Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE)
This study evaluates the safety and efficacy of investigational products in the treatment of knee Osteoarthritis. Half of participants will receive medical chitosan, while the other half will receive sodium hyaluronate.
- Trial name
- NCT02323451
- Testing
- Medical Chitosan, Sodium Hyaluronate Injection
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Shanghai Qisheng Biological Preparation Co., Ltd.
Osteoarthritis Patient
Study of Evaluating the Duration of Efficacy of One Intra Articular Injection of Sodium Hyaluronate 2.0% in Patients With Painful Osteoarthritis of the Knee
A pilot, open, randomised, controlled, add-on study evaluating the duration of efficacy of one intra articular injection of sodium hyaluronate 2.0% in patients with painful osteoarthritis of the knee
- Trial name
- NCT01288001
- Testing
- Ostenil plus
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- TRB Chemedica
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
Oxford Partial Knee Comparative Instrument Pilot Study
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Oxford Partial Knee System using Signature Custom Guides and Conventional Instrumentation.
- Trial name
- NCT01410786
- Testing
- Conventional Instrumentation, Signature Custom Guides
- Where
- New Zealand
- Volunteers
- 35 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Effectiveness Study of the Ivivi SofPulse for Pain Amelioration in Adults With Mild to Moderate Knee Osteoarthritis
The purpose of this study is to determine the effectiveness of non-thermal Pulsed Radio Frequency (PRF) treatment with the Ivivi SofPulse for amelioration of knee pain in patients with mild to moderate Osteoarthritis and to…
- Trial name
- NCT01457742
- Testing
- Ivivi SofPulse
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Amp Orthopedics, Inc.
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Osteoarthritis
A Study to Assess the Safety and Efficacy of an Investigational Drug (MK-686) in Patients With Osteoarthritis (0686-006)
This study is being conducted to assess the safety and tolerability of MK-0686 and to evaluate its efficacy in the treatment of osteoarthritis of the hip or knee in men and women.
- Trial name
- NCT00296569
- Testing
- MK0686
- Volunteers
- 150 people
- Sponsor
- Merck Sharp & Dohme LLC
Knee Osteoarthritis
To Evaluate the Safety and Efficacy of TD0015 Pilulae in Patients with Knee Osteoarthritis
Preclinical trials in animal models have suggested that the estimated dose of TD0015 in clinical presents no safety concerns.The investigational product is TD0015 pilulae, which is based on the traditional prescription named "Độc…
- Trial name
- NCT06657495
- Testing
- TD0015
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sao Thai Duong Joint Stock Company
Osteoarthritis of the Knee
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
Ketoprofen in a topical patch formulation has been demonstrated to be effective for treating mild to moderate pain caused by various musculoskeletal disorders.
- Trial name
- NCT00792727
- Testing
- ketoprofen Patch
- Where
- 36 sites in United States
- Volunteers
- 380 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Knee Osteoarthritis
Pharmacokinetics of Imrecoxib in Subjects With Hepatic Insufficiency
This clinical research study will assess pharmacokinetics and the safety of Imrecoxib in patients with impaired hepatic function as compared to healthy volunteers.
- Trial name
- NCT02456688
- Testing
- Imrecoxib
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Osteoarthritis, Knee
Mesenchymal Stem Cells for The Treatment of Knee Osteoarthritis (KOA).
The clinical study with UMC119-06-05 is designed to investigate the safety in patients with mild to moderate knee osteoarthritis (KOA).
- Trial name
- NCT04893174
- Testing
- UMC119-06-05, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Osteoarthritis, Knee, Osteoarthritis, Hip
A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections
This study will investigate the safety of three fixed dose levels of tanezumab (2.5 mg, 5 mg, and 10 mg) administered at an 8-week interval by subcutaneous injection multiple (7) times during the study treatment period.
- Trial name
- NCT00994890
- Testing
- Tanezumab 2.5 mg, Tanezumab 5 mg, Tanezumab 10 mg
- Where
- 100 sites in United States
- Volunteers
- 679 people
- Sponsor
- Pfizer
Knee Osteoarthritis
An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA
An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX 4975-05 Intra-articular Injection in Subjects with Chronic, Moderate-to-Severe Osteoarthritis Knee Pain.
- Trial name
- NCT03661996
- Testing
- CNTX-4975-05, Lidocaine without epinephrine, ElastoGel
- Where
- 28 sites in United States
- Volunteers
- 854 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis of the Knee
Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthritis of the Knee
This is a randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of Intra-Articular (IA) verapamil in the treatment of joint pain in patients with knee osteoarthritis…
- Trial name
- NCT01645709
- Testing
- Verapamil
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Calosyn Pharma, Inc.
Osteoarthritis, Knee, Osteoarthritis
Phase 4 Study of Laybon Tab. in Knee Osteoarthritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis.
- Trial name
- NCT07203547
- Testing
- Layla Tab., Laybon Tab.
- Volunteers
- 172 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Osteoarthritis, Avascular Necrosis
Persona Partial Knee Clinical Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available Persona Partial Knee System.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures
- Trial name
- NCT03034811
- Testing
- Persona Partial Knee system
- Where
- 24 sites in United States, Austria and 8 more
- Volunteers
- 757 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Efficacy and Safety of ELIXCYTE Intra-articular Injection in Subject With Knee Osteoarthritis
This is a Phase III, double-blinded, placebo-controlled, multicenter study to investigate the efficacy and safety of a new study intervention, ELIXCYTE, compared to placebo (normal saline) in subjects with knee osteoarthritis.
- Trial name
- NCT05526001
- Testing
- ELIXCYTE, Saline
- Where
- 4 sites in Taiwan
- Volunteers
- 165 people
- Sponsor
- UnicoCell Biomed CO. LTD
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