Clinical trials: Knee Arthrosis,
Knee Osteoarthritis
Comparison of the Efficacy, Tolerability and Safety of actiTENS to Those of Level 2 Analgesic Treatments.
This is a phase 3, multicentre, prospective, single-blind on principal efficacy criterion, 2 parallel groups, randomized, controlled clinical study comparing efficacy and safety of actiTENS versus systemic level 2 analgesics…
- Trial name
- ArthroTENS (NCT03902340)
- Testing
- ActiTENS, Level 2 Analgesic Treatments
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Sublimed
Osteoarthritis
Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee
An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in patients who have pain associated with osteoarthritis of the knee despite…
- Trial name
- NCT05377489
- Testing
- RTX-GRT7039
- Where
- 96 sites in United States, Bulgaria and 5 more
- Volunteers
- 714 people
- Sponsor
- Grünenthal GmbH
Type2diabetes, Rheumatoid Arthritis
Understanding Ayurveda Disease Conditions and Treatment Responses
The goal of this observational study is to assess Prakriti \& Vikriti in patients visiting OPD of IIISM department, SRM hospital.
- Conditions
- Type2diabetes, Rheumatoid Arthritis, Osteo Arthritis Knee, Skin Diseases
- Trial name
- NCT06167226
- Testing
- Personalized Ayurveda treatment protocol
- Where
- India
- Volunteers
- 497 people
- Sponsor
- Ayurai Private Limited
Osteoarthritis, Knee
nSTRIDE APS Versus Hyaluronic Acid for Knee Osteoarthritis
This is a two-phase multicenter, double-blind, randomized, prospective evaluation of intra-articular injection(s) comparing APS to intra-articular HA injection(s).
- Trial name
- NCT03182374
- Testing
- nSTRIDE APS, Synvisc-One
- Where
- 14 sites in Belgium, Denmark and 8 more
- Volunteers
- 252 people
- Sponsor
- Zimmer Biomet
Hyaluronic Acid
ArtiAid® Plus for Knee Osteoarthritis: A Post-market Study
The goal of this open-label, post-market clinical follow-up study is to demonstrate the safety and performance of ArtiAid® Plus Intra-articular Injection in patients with knee osteoarthritis(OA).
- Trial name
- NCT05881317
- Testing
- ArtiAid® Plus Intra-articular Injection
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Maxigen Biotech Inc.
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Arthropathy of Knee, Arthritis and/or Post-traumatic Degenerative Problems
Optetrak Posterior Stabilized Versus Optetrak Hi-Flex
The purpose of this study is to evaluate the differences in clinical outcomes between the Optetrak® Posterior Stabilized ("Optetrak® PS", Exactech, Gainesville, FL) and the Optetrak® Hi-Flex™ ("Optetrak® HF", Exactech…
- Trial name
- NCT00808613
- Testing
- Optetrak PS, Optetrak Hi-Flex
- Where
- United States
- Sponsor
- Exactech
Knee Osteoarthritis
Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part II
Study objectives: Part 1 TDU11685 To assess in patients with knee Osteoarthritis (OA), the safety, tolerability and pharmacokinetics (PK) of single intra-articular doses of SAR113945.
- Trial name
- NCT01598415
- Testing
- SAR113945
- Where
- 2 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Sanofi
Knee Osteoarthritis
Study to Evaluate the Digestive Tolerability of ART44 Versus ART®50 in Patients With Osteoarthritis of the Knee
The primary objective of this study, comparing ART 44 to ART 50, will be the evaluation of digestive tolerability (and in particular of diarrhoea).
- Trial name
- NCT01009671
- Testing
- ART 44, ART 50
- Volunteers
- 210 people
- Sponsor
- Laboratoires NEGMA
Osteoarthritis of the Knee
A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee.
The primary objective of the study is to assess the effectiveness of alpha-D Glucosamine Sulfate/Standardized Extract of Ginkgo Biloba Leaf versus a comparator product on osteoarthritis pain as assessed by the between group…
- Trial name
- 13GOHJ (NCT02604381)
- Testing
- Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Extract
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- KGK Science Inc.
Osteoarthritis, Avascular Necrosis
Persona Partial Knee Clinical Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available Persona Partial Knee System.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures
- Trial name
- NCT03034811
- Testing
- Persona Partial Knee system
- Where
- 24 sites in United States, Austria and 8 more
- Volunteers
- 757 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Degenerative Arthritis
Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting
The primary objective of the study is to determine how the short-term outcome of subjects implanted with the JOURNEY™ II BCS Total Knee System compares to subjects implanted with other PS total knee systems, and to determine if…
- Conditions
- Osteoarthritis, Degenerative Arthritis, Traumatic Arthritis
- Trial name
- NCT02820766
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Smith & Nephew, Inc.
Pain
Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee
The primary aim of this study is to investigate if AZD1386 is efficacious as an analgesic in patients with osteoarthritis of the knee and at what dose.
- Trial name
- OA19 (NCT00878501)
- Testing
- AZD1386
- Where
- 41 sites in Bulgaria, Canada and 5 more
- Volunteers
- 241 people
- Sponsor
- AstraZeneca
Osteoarthritis, Knee
Interventistic Clinical Investigation on the Use of Medical Device in Subjects With Mild-moderate Osteoarticular Pain
Evaluation of the performance and safety of ArToFILL in subjects with mild to moderate osteoarticular pain
- Trial name
- NCT06422169
- Testing
- ArToFILL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- PromoPharma spa
Joint Replacement, Arthropathy
The restor3d Outcomes Registry
The restor3d Outcomes Registry is a prospective, longitudinal, decentralized study designed to capture patient-reported outcomes (PROs) from adults who have received an FDA-cleared or approved restor3d patient-specific orthopedic…
- Trial name
- NCT07563803
- Testing
- Patient-Specific Orthopedic Implant
- Where
- United States
- Volunteers
- 2,250 people
- Sponsor
- Restor3D
Osteoarthritis, Knee
Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (Europe)
To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.
- Trial name
- NCT00630929
- Testing
- Ibuprofen, Celecoxib
- Where
- 33 sites in Germany, Spain and 1 more
- Volunteers
- 388 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Knee Osteoarthritis
A Study to Compare the Press Fit Condylar (P.F.C.) Sigma Rotating-platform High-flexion (RP-F) Versus the Press Fit Condylar (P.F.C.) Sigma Rotating-platform (RP) Knee Implants
The main objective of this study is to determine if the P.F.C. Sigma RP-F Knee delivers a greater post-operative range of motion (ROM) compared with the P.F.C. Sigma RP Knee in primary TKA.
- Trial name
- NCT00733369
- Testing
- PFC Sigma RP-F, PFC Sigma RP
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 106 people
- Sponsor
- DePuy International
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Osteo Arthritis Knee
Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus corticosteroid injection for the treatment of pain and function associated with K/L grade 2/3 knee…
- Trial name
- ARISE (NCT05660772)
- Testing
- Microfragmented Adipose Tissue, Corticosteroid
- Where
- 18 sites in United States
- Volunteers
- 173 people
- Sponsor
- Lipogems International spa
Osteoarthritis
The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy and safety of intraarticular Invossa K Injection patients diagnosed with Kellgren \& Lawrence grade 2 knee osteoarthritis.
- Trial name
- NCT03383471
- Testing
- Invossa K Inj.
- Where
- 17 sites in South Korea
- Volunteers
- 146 people
- Sponsor
- Kolon Life Science
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