Clinical trials: Knee Degenerative Disease
Osteoarthritis, Joint Disease
Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment
Adipose-derived stromal vascular fraction cells (SVFs) include regenerative cell populations (hematopoietic cells, pericytes, endothelial cells and progenitors, stromal/stem cells) and thus are potentially important as new…
- Conditions
- Osteoarthritis, Joint Disease, Osteoarthritis,Knee, Arthritis, Degenerative
- Trial name
- NCT02967874
- Testing
- Intra-articular auto-SVFs injection, Hyaluronic Acid
- Where
- Russia
- Volunteers
- 27 people
- Sponsor
- Russian Academy of Medical Sciences
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Alberta Hip and Knee Replacement Project
The study aims to determine if a New Arthroplasty Care Model, established on evidence-based medicine and best practices, will improve patient outcomes and improve cost effectiveness for patients with severe degenerative joint…
- Trial name
- NCT00277186
- Testing
- New Care Continuum
- Where
- Canada
- Volunteers
- 3,434 people
- Sponsor
- Alberta Bone and Joint Health Institute
Knee Osteoarthritis, Cartilage Degeneration
Impact of High Tibial Osteotomy in Preventing Degenerative Disease Progression in Medial Knee Osteoarthritis.
High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression.
- Conditions
- Knee Osteoarthritis, Cartilage Degeneration, Malalignment, Bone
- Trial name
- HTO-IOR (NCT05865899)
- Testing
- valgus producing medial opening wedge high tibial osteotomy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteo Arthritis Knee, Total Knee Replacement
LEGION™ Primary Safety and Efficacy
This study will look at the health results of using the LEGION™ Primary Knee System over a period of ten (10) years. This type of surgery uses an artificial knee made of plastic and metal.
- Trial name
- NCT04040985
- Testing
- Total Knee Arthroplasty using LEGION™ Total Knee System
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Genicular Artery Embolization for the Treatment of Knee Osteoarthritis
The purpose of this clinical research study is to examine whether Embozene treatment of the genicular artery is a safe and effective way to treat arthritic knee pain.
- Trial name
- GAE-OA (NCT03491397)
- Testing
- Embozene MicroSpheres
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Siddharth Padia, MD
Stem Cell, Gonarthrosis
WHARTON JELLY ORIGINATED MESENCHIAL STEM CELL in GONARTHROSIS
Osteoarthritis (OA) is a progressive disease characterized by degeneration of the joint cartilage, which is involved in the immune system leading to proinflammatory cytokine and metalloproteinase release.
- Trial name
- WHAMKO (NCT04313894)
- Testing
- Wharton Jelly Originated Mesencimal Stem Cell
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- TC Erciyes University
Knee Osteoarthritis, Degenerative Joint Disease
Milnacipran for Chronic Pain in Knee Osteoarthritis
The patients are asked to take part in this study because you have chronic pain as a result of knee osteoarthritis. This study is done to investigate the pain relieving effects of the study drug Savella (milnacipran HCl) for…
- Conditions
- Knee Osteoarthritis, Degenerative Joint Disease, Chronic Pain
- Trial name
- KOA (NCT01510457)
- Testing
- Milnacipran
- Volunteers
- 46 people
- Sponsor
- Dr. Norman Harden
Knee Osteoarthritis
Changes of the Single Limb Standing Balance After Total Knee Arthroplasty in Degenerative Osteoarthritis
It was well known that total knee arthroplasty could improve the previously impaired proprioception in degenerative osteoarthritis. Most current researches have been focused on the change of the proprioception.
- Trial name
- NCT01192334
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Ulsan University Hospital
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Degenerative Osteoarthritis
Continuous Distal Adductor Canal Block With Periarticular Local Anesthetic Infiltration Versus Continuous Distal Adductor Canal Block Alone for Analgesia After Total Knee Arthroplasty
Continuous administration of local anesthetics to the distal adductor canal could spread into the popliteal fossa and contribute to analgesic effects on posterior knee pain.
- Trial name
- NCT05427019
- Testing
- Distal adductor canal block, Distal adductor canal block and Periarticular block
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Osteoarthritis; Primary, Degenerative Joint Disease of Knee
A Multidisciplinary Intervention in Total Knee Arthroplasty
The purpose of this study is to investigate the effectiveness of cognitive behavioral therapy delivered as an e-therapy program, combined with physical exercise delivered by physiotherapists, for patients on waiting list for…
- Trial name
- MultiKnee (NCT03771430)
- Testing
- Osteoarthritis education, exercise and CBT, Total Knee Arthroplasty
- Where
- 3 sites in Norway
- Volunteers
- 282 people
- Sponsor
- Lovisenberg Diakonale Hospital
Knee Osteoarthritis
Low Level Laser Therapy in Knee Osteoarthritis
The study will be Randomized Controlled Trial. It will be conducted in Allied Hospital Faisalabad. The study will be completed in four months duration. Consecutive sampling technique will be used for data collection.
- Trial name
- NCT04682171
- Testing
- Low level laser therapy, Conventional Exercise Therapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Healthy, Degenerative Disease
Establishment of Biomechanical- and AI- Based Rehabilitation Strategies for Pain Inducing Lifestyles
To develop biomechanical indicators for pain-inducing lifestyles and apply lifestyle strategies for patients and confirm their effectiveness to be used in artificial intelligence-based digital treatment devices.
- Trial name
- NCT05905029
- Where
- 2 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bundang CHA Hospital
Knee Osteoarthritis
Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy
Stromal vascular fraction of cells (SVF) will be extracted from lipoaspirate by enzymatic digestion. SVF will be administered in a single dose intraarticularly 4 weeks after arthroscopic debridement.
- Trial name
- NCT02827851
- Testing
- Liposuction, SVF isolation, Intraarticular administration of autologous SVF
- Where
- 4 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Knee Osteoarthritis, Knee Injuries
The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis
This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.
- Trial name
- NCT05294224
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara Özen Oruk
Osteoarthritis, Knee
Safety and Efficacy of the Journey II BCS Total Knee System
Assess the safety and efficacy of the JOURNEY II BCS Total Knee System in subjects with degenerative knee disease requiring primary total knee replacement.
- Trial name
- NIMBLE (NCT01705067)
- Testing
- TKA with Journey II BCS Total Knee System
- Where
- 12 sites in United States
- Volunteers
- 209 people
- Sponsor
- Smith & Nephew, Inc.
Knee
Structured Rehabilitation Program for Patients With Total Knee Replacement
This study will be a randomized controlled trial. This study will be conducted in Horizon Hospital Lahore. A sample size of 26 patients will be taken. Patients will be divided into two groups by lottery method.
- Trial name
- NCT04694625
- Testing
- Structured Rehabilitation Program, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Degenerative Disease, Meniscus Tear
The Video-Based Exercise Programs in Degenerative Meniscus Tears
This randomized controlled trial aims to investigate the efficacy of the video-based exercise programs in patients with degenerative meniscus tears.
- Conditions
- Degenerative Disease, Meniscus Tear, Knee Pain Swelling
- Trial name
- NCT05266365
- Testing
- The video-based exercise (VBE), The standard exercise (SE), The hybrid exercise (HE)
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Istanbul University - Cerrahpasa
Osteoarthritis
To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).
This is a Randomized, Double-Blind, Placebo-Controlled, Parallel-Design, Multiple-Site Clinical Study to Evaluate the Therapeutic Equivalence of Diclofenac Sodium Gel, 1% (Glenmark Pharmaceuticals Ltd) to Voltaren® Gel…
- Trial name
- NCT02596451
- Testing
- Diclofenac Sodium gel, 1%, Voltaren® Gel
- Where
- 44 sites in United States
- Volunteers
- 1,164 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Non-inflammatory Degenerative Joint Disease (NIDJD) of the Knee
Safety and Performance of the Journey™ II UNI Unicompartmental Knee System
This clinical study will evaluate the early to midterm safety and performance of the JOURNEY™ II UNI UKS in patients with non-inflammatory degenerative joint disease of the knee requiring lateral or medial knee compartment…
- Trial name
- JII-Uni (NCT03768128)
- Testing
- Journey™ II UNI Unicompartmental Knee System
- Where
- 6 sites in United States, Italy and 1 more
- Volunteers
- 154 people
- Sponsor
- Smith & Nephew, Inc.